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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya KESANS : International Journal of Health and Science
Pionera Seconda Giyanti Putri
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Chemistry Health Professions Medicine & Pharmacology Physics Public Health

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Tandem peptide lipid CRISPR-Cas9 complex combating APP and APOE4 gene abnormality in Alzheimer's disease Ilham Rahmanto; Maulana Bagus Adi Cahyono; Husnul Khatimah; Rahmi Nugraningrum; Pionera Seconda Giyanti Putri; Nurul Zulfa Sahiruddin; Nabila Rahmaniah; Pradana Zaky Romadhon
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 01 (2024): Qanun Medika Vol 08 No 01 January 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i01.16054

Abstract

Alzheimer's attacks 24 million global population and dominates 60-80% of existing cases of dementia. It causes the accumulation of beta-amyloid (Aβ) plaques in the hippocampus and entorhinal cortex, resulting in decreased mass from the brain. Recent studies have shown that the manifestation of this disease is due to an overaccumulation of abnormal Aβ protein due to abnormalities in the APP and APOE4 genes. Point mutations in the APP gene will create the toxic form of Aβ protein, namely Aβ42, and the toxic APOE4 gene will accelerate the onset of Aβ42 deposition and pro-inflammatory activity that exacerbates the degenerative process of the brain. Gene editing as a potential definitive therapy was recently a concern by researchers. CRISPR-Cas9 repairs the APP gene and substitutes the APOE4 gene with APOE3 by modifying the gene's DNA sequence. Nano complex CRISPR-Cas9 tandem peptide lipid is a model for clinicians to target brain nerve cells. In vivo research on an Alzheimer's mouse model proved the potential of nano-complex-based peptides as carriers of CRISPR-Cas9 in brain nerve cells. This engineering technology offers satisfactory results with high precision, minimal side effects, and a relatively low price for long-term therapeutic effects and even a lifetime.
Exploring Contraceptive Use Among Reproductive Woman at Pamekasan, Madura Island Dwi Jayanti, Ratna; Ivon Diah Wittiarika; Agnestia Naning Dian Lovita; Euvanggelia Dwilda Ferdinandus; Nurul Azizah; Rafhani Rosyidah; Pionera Seconda Giyanti Putri
Jurnal KESANS : Kesehatan dan Sains Vol 5 No 5 (2026): KESANS: International Journal of Health and Science
Publisher : Rifa'Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/kesans.v5i5.572

Abstract

Introduction: Unintended pregnancy remains a major global and national concern, with 64 unintended pregnancies per 1,000 women worldwide and 15.5% of pregnancies in Indonesia reported as unwanted; the Indonesian government addresses this issue through the Family Planning program, where contraceptive use has reached 62.38% nationally. Even while long-term methods like IUDs and implants are very effective, their use is still inconsistent, whereas short-term like injectable contraception is most often used. Objective: this study aimed to exploring contraceptive use among reproductive woman at rural area. Method: A cross-sectional study using consecutive sampling involved 69 women of reproductive age completing structured questionnaires on contraceptive use, analyzed using descriptive statistics. Result and Discussion: Most respondent in 40-49 group age (42%), have secondary education level (57%), have no working (77%), and Married woman (91%). Most participants (54.4%) not used contraception although 74% ever used contraception, with the hormone injection were the preferred contraceptive methods. Conclusions: This study show a sociodemographic characteristic that can be analyzed in the future study.
Co-Authors Agnestia Naning Dian Lovita Dwi Jayanti, Ratna Ferdinandus, Euvanggelia Dwilda Husnul Khatimah Ilham Rahmanto Ivon Diah Wittiarika Maulana Bagus Adi Cahyono Nabila Rahmaniah NURUL AZIZAH Nurul Zulfa Sahiruddin Rafhani Rosyidah Rahmi Nugraningrum Romadhon, Pradana Zaky