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All Journal JURNAL FARMASIMED (JFM) Journal of Pharmaceutical and Sciences. Jurnal Pharmactive
Ni Luh Gde Mona Monika
Institut Teknologi dan Kesehatan Bintang Persada
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

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Formulasi Transdermal Patch Nanoemulgel Ekstrak Dadap Serep (Erythrina subumbrans (Hassk.) Merr.) dan Rimpang Kencur (Kaempferia galanga L.) sebagai Kandidat Laktagogum Herbal Berbasis Usadha Ni Luh Gde Mona Monika; Ella Yunita
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1510

Abstract

Traditional Usadha-based herbal lactagogues, such as Erythrina subumbrans and Kaempferia galanga, are used by lactating mothers; however, their delivery in practical, standardized forms is limited. This study aimed to formulate a nanoemulgel transdermal patch containing E. subumbrans extract and K. galanga extract, evaluate its physicochemical properties, and assess its safety for skin irritation as a potential herbal lactagogue. Extracts of E. subumbrans and K. galanga were added to the nanoemulsion base. The nanoemulsions were incorporated into HPMC/PVP-based transdermal patch matrices by solvent casting. The resulting patches were evaluated for physicochemical properties and tested for skin irritation. Phytochemical screening confirmed the presence of flavonoids, tannins, triterpenoids, saponins, and alkaloids in both extracts. The total flavonoid contents were 47.44 mg QE/g for E. subumbrans and 36.79 mg QE/g for K. galanga. The nanoemulsion exhibited greater than 90% transmittance, mean droplet size of 7.79 nm, and polydispersity index (PDI) of 0.193. The patches met acceptable physical criteria, including a thickness of 0.20 mm, weight variation with %CV less than 10%, and folding endurance over 300. pH values ranged from 6.00 to 6.58. In a human patch test, no erythema or edema was observed; only mild pruritus (mean = 0.2) was reported in two participants. The formulated nanoemulgel transdermal patches demonstrated favorable physicochemical properties and were non-irritating. These patches show potential as a herbal lactagogue delivery system; further studies on lactation  efficacy and long-term stability are recommended.
PERBANDINGAN UJI AKTIVITAS ANTIOKSIDAN INFUSA DAN DEKOKTA BUNGA TELANG (Clitoria ternatea L.) DENGAN METODE DPPH Ni Luh Gde Mona Monika; I Made Wahyu Yogatama; Nyoman Rudi Kusuma; Ni Putu Ria Artini
Journal Pharmactive Vol. 4 No. 2 (2025): Jurnal Pharmactive Oktober
Publisher : Institut Teknologi dan Kesehatan Bintang Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64036/0z3ddw47

Abstract

Free radicals are highly reactive molecules that can cause cellular damage and contribute to the development of various degenerative diseases. Butterfly pea flower (Clitoria ternatea L.) is a traditional medicinal plant rich in antioxidant compounds such as flavonoids, anthocyanins, and phenolics. This study aimed to evaluate the antioxidant activity of infusion and decoction preparations of butterfly pea flowers using the DPPH method. The research was conducted through laboratory experiments by measuring the IC?? value using UV-Vis spectrophotometry. The results showed that the infusion extract exhibited very strong antioxidant activity with an IC?? value of 31.25 ppm, while the decoction extract demonstrated moderate antioxidant activity with an IC?? value of 128.66 ppm. The positive control, Vitamin C, showed very strong antioxidant activity with an IC?? value of 14.04 ppm. Based on these findings, the infusion method is more effective at extracting antioxidant compounds than the decoction method. The infusion of butterfly pea flower has potential to be developed as a natural antioxidant source.
In Silico Study of Dysotriflorin Compounds from Majegau Stem Bark (Dysoxylum densiflorum) as a Potential Antihypertensive Agent Putu Esya Elistya; Ni Wayan Rika Kumara Dewi; Ni Luh Gde Mona Monika
Jurnal FARMASIMED (JFM) Vol 9 No 1 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v9i1.3837

Abstract

Hypertension is a non-communicable disease with high prevalence in Indonesia and a major risk factor for cardiovascular disorders. The Renin-Angiotensin-Aldosterone System (RAAS) plays a crucial role in its pathophysiology through activation of Angiotensin-Converting Enzyme (ACE) and Angiotensin II type 1 receptor (AT1R). This study investigates the potential of dysotriflorin A–M, triterpenoid metabolites from the bark of majegau (Dysoxylum densiflorum), as antihypertensive candidates using an in-silico approach. The methods included preparation of ACE and AT1R proteins, optimization of the compound’s 3D structures, and molecular docking simulations with AutoDock Vina. Interaction analysis assessed binding affinity, bond types, and amino acid residues, complemented by toxicity prediction (ProTox) and bioavailability evaluation (Lipinski’s rule). Results showed dysotriflorin A–M had binding affinities ranging from –8.5 to –9.4 kcal/mol for ACE and –8.1 to –9.0 kcal/mol for AT1R, outperforming captopril (–7.4 kcal/mol) and losartan (–8.1 kcal/mol). Hydrogen and hydrophobic interactions supported complex stability. Toxicity prediction indicated LD50 of 2000 mg/kg (class IV, relatively safe), while bioavailability met 4 of 5 Lipinski parameters. In conclusion, dysotriflorin A–M demonstrates promising potential as a natural antihypertensive candidate with favorable safety and bioavailability, warranting further in-vitro and in-vivo validation.
Co-Authors Ella Yunita I Made Wahyu Yogatama Ni Putu Gita Puspita Sari Ni Putu Ria Artini Ni Wayan Rika Kumara Dewi Nyoman Rudi Kusuma Putu Esya Elistya