Article Per Year (5 Year)
p-Index From 2020 - 2025
0.751
P-Index
This Author published in this journals
All Journal Ophthalmologica Indonesiana
Delfi
Unknown Affiliation
Health Professions Medicine & Pharmacology Public Health

Published : 4 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search

 1 
Relationship between Serum Homocysteine Levels and Manganese Superoxide Dismutase (MnSOD) on Retinal Nerve Fiber Layer (RNFL) Thickness in Diabetic Retinopathy and Non-Diabetic Retinopathy Patients: Oral Presentation - Observational Study - Resident Nurrakhmah, Rini; Delfi; Lubis, Rodiah Rahmawaty; Virgayanti, Vanda
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/w9rgsd55

Abstract

Introduction & ObjectivesDiabetic retinopathy is a visual disorder caused by abnormalities in the retina, where there is aprogressive microangiopathy characterized by damage and blockage of fine blood vessels, resultingin impaired nutrition of the retina. This study is to find out the relationship between serumhomocysteine levels and MnSOD on retinal nerve fiber layer (RNFL) thickness in diabeticretinopathy and non-diabetic retinopathy patients. MethodsThis study is an analytic observational case-control study with a total of 31 subjects for each group.3cc of venous blood samples were taken to assess the serum levels of homocysteine and MnSOD andthen analyzed by ELISA method in the integrated laboratory of the USU Medical Faculty. ResultsThere was a significant difference in Avg RNFL and Nasal RNFL thickness between the two groups(p=0.015) with the mean Avg RNFL thickness being 100.94 (SD=17.04) and the mean RNFL nasalthickness being 90.16 (SD=33.68). The highest MnSOD levels were found in non-diabeticretinopathy subjects with a mean of 142.77 (SD=101.77). There was no significant relationshipbetween homocysteine and thickness of superior RNFL (p=0.346), inferior RNFL (p=0.292),temporal RNFL (p=0.109), nasal RNFL (p=0.190). However, a significant association was foundbetween homocysteine and Avg RNFL (p=0.007). ConclusionIn the group of cases of diabetic retinopathy, a significant relationship was found between Hcy andAvg RNFL (p=0.007). An increase in serum homocysteine levels will be followed by a decrease in thethickness of the Avg RNFL.
DIABETES DURATION AND RETINAL NERVE FIBER LAYER THICKNESS RELATED DEGREE OF DIABETIC RETINOPATHY: Oral Presentation - Observational Study - Resident Nadia, Felanda Ahsanu; Sari, Masitha Dewi; Delfi
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/857sg474

Abstract

Introduction & ObjectivesDiabetic retinopathy is an ocular complication of diabetes mellitus (DM). Several studies have shownthat neurodegenerative changes in the retina occur earlier than microvascular changes.Measurement of retinal nerve fiber layer thickness can detect neurodegeneration at an early stage.This study aims to analyze the relationship of diabetes duration and retinal nerve fiber layerthickness with degree of diabetic retinopathy in type 2 diabetes mellitus patients. MethodsThis research was analytic observational research with cross-sectional design. The sample was type2 diabetes mellitus patients with diabetic retinopathy who visited the eye clinic at the University ofSumatera Utara General Hospital. The sample were then analyzed with the Kruskal Wallis test tofind relationship of diabetes duration and retinal nerve fiber layer thickness with degree of diabeticretinopathy in type 2 diabetes mellitus patients. ResultsThe sample of this study were 20 subjects with diabetic retinopathy and 20 subjects without diabeticretinopathy as the control group. The mean duration of having DM in the group of patients with mildNPDR was 5.33 years, with moderate NPDR was 9.13 years and with PDR was 15.33 years. Usingthe Kruskal Wallis test revealed that there was no significant relationship between degree ofdiabetic retinopathy with Avg RNFL (p=0.495), superior RNFL (p=0.385), inferior RNFL (p=0.111),temporal RNFL (p=0.064), nasal RNFL (p=0.535). ConclusionThere was a significant difference between diabetes duration with degree of diabetic retinopathy butno significant between retinal nerve fiber layer thickness with degree of diabetic retinopathy.
ANALYSING THE SIDE EFFECT OF AMIODARONE N CONSUMPTION ON OPTIC NERVE HEAD, CONTRAST SENSITIVITY AND COLOR VISION IN ARRYTHMIA PATIENT: Oral Presentation - Observational Study - Resident Callina Floriana Y. Br. Bangun; Bobby Ramses Erguna Sitepu; Delfi
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/prmxk467

Abstract

Abstract Introduction & Objectives : To analyze the side effect of duration consumption of amiodarone on ONH, contrast sensitivity and color vision in arrythmia patient Methods : This study was an analytical observational study with cross sectional design. A total of 23 subjects with arrhythmias taking amiodarone were included in the study. Sampling was carried out from April 2022-August 2022 at the Eye Polyclinic and Cardiology Polyclinic. Results : Most of the subjects were female, 12 people (52.2%) with a mean age of 59 years. The results of the examination showed that two subjects had decreased vision, ONH edema and decreased contrast sensitivity in the right eye where the mean duration of amiodarone consumption was 4.5 months. The results of binocular color vision examination were normal in all study subjects. There was a significant effect of the consumption duration of amiodarone on ONH (p=0.024) and on contrast sensitivity (p=0.022) Conclusion : There was a significant effect of the duration consumption of amiodarone on ONH and contrast sensitivity in arrythmia patient
The Relationship Between Tumor Necrosis Factor-Alpha (TNF-α) with Retinal Nerve Fiber Layer (RNFL) Thickness in Diabetic Retinopathy Patients at Prof. CPL Universitas Sumatera Utara General Hospital and Affiliated Hospital Putra, Wahyu Medsa Yeltas; Delfi; Ashar, Taufik
Majalah Oftalmologi Indonesia Vol 51 No 2 (2025): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v51i2.101724

Abstract

Introduction: Retinal neurodegeneration may be an early indicator of diabetic retinopathy, the second most common complication after nephropathy. Tumor Necrosis Factor-Alpha (TNF-α) plays a role in the pathogenesis of inflammatory and neovascular eye disorders and is associated with intraocular inflammatory diseases like macular edema and proliferative diabetic retinopathy. This study aims to find the relationship between TNF-α levels and Retinal Nerve Fiber Layer (RNFL) thickness in diabetic retinopathy patients at Prof. CPL Universitas Sumatera Utara General Hospital and affiliated hospital.   Methods: This cross-sectional study included 45 patients with type 2 DM and diabetic retinopathy at Prof. CPL Universitas Sumatera Utara General Hospital and affiliated hospital from March to June 2024. RNFL and posterior segment examinations were conducted. TNF-α levels were measured from blood samples.Blood sugar data were taken from medical records.   Results: Of the 45 participants, 24 were men (53.3%) and 21 women (46.7%). 32 (71.1%) had DM for >5 years, and 27 (60%) experienced PDR. Highest location for RNFL thickness examination was superior (19, 42.2%). Average TNF-α with thin RNFL was 65.67 ng/L, and with thick RNFL was 64.78 ng/L. Mean TNF-α with thin superior RNFL was 65.74 ng/L, and thick was 63.70 ng/L. Mean TNF-α with thin inferior RNFL was 65.73 ng/L, and thick was 63.9 ng/L. Mean TNF-α with thin temporal RNFL was 68.73 ng/L, and thick was 67.19 ng/L. Mean TNF-α with thick nasal RNFL was 67.06 ng/L.   Conclusion: There was no statistically significant relationship between TNF-α and RNFL thickness in diabetic retinopathy patients.
Co-Authors Bobby Ramses Erguna Sitepu Callina Floriana Y. Br. Bangun Lubis, Rodiah Rahmawaty Nadia, Felanda Ahsanu Nurrakhmah, Rini Putra, Wahyu Medsa Yeltas Sari, Masitha Dewi Taufik Ashar Virgayanti , Vanda