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Analisis Farmakokinetik Klinik Dosis Obat Pasien Hipertensi Komplikasi Gagal Di RSUD Dr. Pirngadi Medan Nilsya Febrika Zebua; Peri Aisyah Zubaidi; Sumardi; Suprianto; Shofian Syarifuddin; Risma Yeni
Jurnal Indah Sains dan Klinis Vol 4 No 1 (2023): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v4i1.06

Background: Hospitals are health service providers providing emergency care, outpatient and inpatient. Hypertension occurs when blood pressure is above normal. Clinical conditions that require dialysis treatment have a tendency to kidney failure. This effort is related to the field of clinical pharmacokinetics. Objective: The study was conducted to analyze the dose of drug administration in conditions complicated by kidney failure in hypertensive patients. Methods: The study went through a sampling stage of data from hypertensive patients complicated by kidney failure, data according to inclusion criteria, calculation of creatinine clearance, analysis of dose adjustments and creatinine clearance. Results: The study obtained 170 data, which met the inclusion criteria of 30 data. Drugs with a narrow therapeutic index and worsening kidney function that patients received included: digoxin, captopril, ranitidine, furosemide, ciprofloxacin, and cefriaxone in 2, 13, 9, 12, 3, and 8 cases respectively. Conclusion: According to dose adjustment calculations for patient creatinine clearance, it was found that the drug exceeded the individual dose in 6 out of 9; 8 of 13; and 2 cases each using ranitidine, captopril, digoxin

Antioxidant Activity and Total Flavonoid of Extract of Bark Vitex pinnata L. Zulfan; Yessi Febriani; Sumardi
Jurnal Indah Sains dan Klinis Vol 4 No 3 (2023): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v4i3.04

Background: The bark of Vitex pinnata L is not yet optimally utilized, primarily being used in boat construction while the remaining material becomes waste that is either buried or burned in trash. Therefore, it is necessary to explore more efficient and economically valuable uses for the bark of the laban tree. Objective: The aim of this research is to identify the chemical compounds, flavonoid content, and antioxidant activity present in the methanol extract of Vitex pinnata L bark. Method: Phytochemical screening was conducted on the methanol extract of Vitex pinnata L. bark. To obtain the extract, the simplicia powder was macerated using methanol as the solvent. The total flavonoid content and antioxidant activity were then tested using the 1,1-diphenyl-2-picryhydrazil (DPPH) method. Results: the phytochemical screening indicated that the Vitex pinnata L. bark extract contains alkaloids, flavonoids, and tannins. The total flavonoid test yielded 17.27%, and the antioxidant activity test revealed that the methanol extract of the laban tree bark has antioxidant activity with an IC50 value of 43.22 ppm. Conclusion: This extract has strong potential as an antioxidant agent.

Formulation of Ethanolic Extract of Guava Fruit Flesh (Psidium guajava L.) as a Lip Moisturizer Yoli Anathasia; Suryanto; Sudewi; Sumardi
Jurnal Indah Sains dan Klinis Vol 4 No 2 (2023): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v4i2.03

Background: Guava fruit (Psidium guajava L.) is known for its antioxidant properties, attributed to its content of beta carotene and phenolic compounds such as quercetin, guavin, protocatechuic acid, ferulic acid, gallic acid, caffeic acid, and vitamin C. However, the use of guava fruit flesh in lip balm formulations has not been extensively studied. Objective: This research aims to determine whether the ethanolic extract of guava fruit flesh can be formulated into a lip balm preparation that provides moisture at certain concentrations without irritating the lip skin. Method: This study utilized the guava fruit flesh (Psidium guajava L.) as the test material. Phytochemical analysis and lip balm formulations were prepared at concentrations of 2.5%, 5%, 7.5%, 10%, along with a blank control. Commercially available products were used as a comparison. The physical quality evaluation of the formulations included tests for homogeneity, pH, melting point, stability, preference, and effectiveness on the lip skin using a moisture checker device. Results: the ethanolic extract of guava fruit flesh (Psidium guajava L.) can be formulated into a lip balm. The pH of the lip balm formulations ranged from 6.0 to 6.2 immediately after preparation and from 5.8 to 6.1 after 12 weeks of storage. The melting point of the formulations was between 58-62°C. The lip balm with a concentration of 7.5% was the most preferred in the preference test. The formulations remained stable in terms of odor, color, and shape over a 12-week storage period. The lip balm with a 10% concentration provided the best moisturizing effect on the lips, achieving a 23.1% improvement, while the commercial comparison product had an average recovery rate of 26.1%, falling under the "moist" category. Conclusion: the ethanolic extract lip balm formulations did not cause any irritation to the skin and potential used as moisturizer

Preformulation of Lemongrass Oil (Cymbopogon citrates (DC) Stapf) and Turmeric Extract (Curcuma xanthorrhiza Roxb.) on the Growth of Escherichia coli Bacteria Werti; Vriezka Mierza; Sumardi
Jurnal Indah Sains dan Klinis Vol 4 No 2 (2023): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v4i2.05

Background: Lemongrass and turmeric are medicinal plants known for their antibacterial properties due to the presence of compounds such as alkaloids and flavonoids in lemongrass oil, and saponins and flavonoids in turmeric. Typically, lemongrass oil is used for massage oil, and turmeric is commonly used as a spice and traditional medicine. However, there is limited scientific information on the combination of both. Objective: This study aims to evaluate the antibacterial potential of a formulation combining lemongrass oil and turmeric extract against Escherichia coli bacteria, both in extract form. Method: The research steps include the preparation of the plant materials, extraction, granulation process, and antibacterial testing. Extraction is performed using boiling with distilled water as the solvent. The antibacterial activity testing method employed is the good diffusion method. Results: The formulation of lemongrass oil (Cymbopogon citratus (DC) Stapf) and turmeric (Curcuma xanthorrhiza Roxb.) has demonstrated antibacterial activity against Escherichia coli in both extract and granule forms across five different formulations. Conclusion: The highest inhibition diameter was observed with the combination of lemongrass oil and turmeric extract at 19.05 mm, and lemongrass oil and turmeric granules at 18.71 mm, in Formula 3 (0.25 lemongrass oil: 0.75 turmeric).

Kuantifikasi Inversi Galaktomanan Kolang-Kaling (Arenga pinnata Merr.) dengan Iodometri Nilsya Febrika Zebua Zebua; Sumardi; Suprianto; Putri Addina
Jurnal Indah Sains dan Klinis Vol 5 No 1 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i1.03

Background: Kolang-Kaling (Arenga pinnata Merr.) belongs to the Arecaceae family as a source of natural polysaccharides in the form of galactomannan which is usually used as an additional ingredient. Objective: The study was aimed at determining whether galactose-mannose from Kolang-Kaling (GKK) could be separated using chromatography and its levels using the iodometry method. Method: Extraction of galactomannan using distilled water as a solvent. Purification by Paper Chromatography using WEB [Water: Ethanol: Butanol] mobile phase; WAB [Water: Acetate: Butanol]; CH3COOH 10.0% and 50.0%; CA 10.0% and 20.0%. Purification by TLC uses a variation of the EA: H mobile phase. Results: The GKK extraction yield was 18,5 g (3.7%). The levels before and after inversion were 85.53% and 90.23% with a galactose-mannose standard of 94.52%. Conclusion: Galactomannan can be obtained from Kolang-Kaling extraction and its levels are determined using the iodometry method

Antioxidant Effectiveness of Transparent Solid Soap from Red and White Pomelo (Citrus grandis (L.) Osbeck) Extracts Septi Noiman Lase; Eva Sartika Dasopang; Supomo; Sumardi
Jurnal Indah Sains dan Klinis Vol 5 No 2 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i2.03

Background: Pomelo (Citrus grandis (L.) Osbeck) contains limonoids, flavonoids, naringin, and lycopene, which enhance the effects of ascorbic acid (vitamin C) in the body. Objective: This study aims to determine whether the extracts from red and white varieties of pomelo possess antioxidant properties and can be formulated into transparent solid soap that meets the quality standards set by SNI 3235-2016. Method: This experimental research utilized extracts from red and white varieties of pomelo. The research stages included sample preparation, processing of test materials, formulation of transparent solid soap with the addition of the extracts, and evaluation tests including organoleptic tests, pH tests, foam height tests, moisture content tests, and antioxidant activity tests using the DPPH method measured with UV-VIS spectrophotometry at concentrations of 60 μg/ml, 50 μg/ml, 40 μg/ml, 30 μg/ml, and 20 μg/ml. The results showed that both red and white pomelo extracts contain the same groups of compounds, including alkaloids, tannins, steroids, triterpenoids, and ascorbic acid. Results: Antioxidant tests indicated that the red pomelo extract has "moderate" antioxidant activity with an IC50 value of 185.086 μg/ml, while the white pomelo extract is "inactive" with an IC50 value of 564.309 μg/ml. The transparent solid soap exhibited "moderate" antioxidant activity with an IC50 value of 206.592 μg/ml. Conclusion: The transparent solid soap with red pomelo extract showed "weak" antioxidant activity with an IC50 value of 295.531 μg/ml, and the soap with white pomelo extract was "inactive" with an IC50 value of 130.207 μg/ml. The evaluation results for the transparent solid soap, including organoleptic properties, pH, foam height, and moisture content, conformed to the standards set by SNI 3235-2016

Activity of Hand Sanitizer Gel from Coconut Shell Liquid Smoke with a Combination Base of Galactomannan and Carbopol 940 Against Staphylococcus aureus Bacteria Tari Putri Utami Rizki; Nilsya Febrika Zebua; Supomo; Sumardi
Jurnal Indah Sains dan Klinis Vol 5 No 2 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i2.04

Background: Liquid smoke acts as an antimicrobial and antioxidant, this is related to the concentration of compounds namely phenol, carbonyl and acid. Bacteria Staphylococcus aureus is classified as a gram-positive bacteria and bacteria which is commonly found on the skin, nasal passages and respiratory tract. Hands sanitizer is an antiseptic in gel form that is often used for washing hands without water. One of the natural polymers used is galactomannan. Galactomannan is a natural polymer, namely a polysaccharide isolated from seeds. The endosperm is mainly from the Arecaceae family which consists of the main chain of mannan and galactose in the side chain. Objective: Study of activity test of Hand Sanitizer Gel from coconut shell liquid smoke with a combination of galactomannan and carbopol 940 base against Staphylococcus aureus bacteria. Method: the aim of this research formulating a hand sanitizer with the active ingredient liquid shell smoke coconut can kill Staphylococcus aureus bacteria. The research was experimental with work stages including: collecting coconut shell liquid smoke, making galactomannan from palm fruit determining the concentration of coconut shell liquid smoke hand sanitizer gel, namely 0.1%, 1%, 1.5%, determining the diameter of the inhibition zone of coconut shell liquid smoke using the well method, organoleptic test, homogeneity test, pH test, spreadability test, viscosity test, preparation stability test, irritation test on volunteers and testing antibacterial activity of hand sanitizer gel preparations with liquid smoke as the active ingredient coconut shell against Staphylococcus aureus bacteria. Results: Coconut shell liquid smoke can inhibit bacterial growth Staphylococcus aureus is greatest at a concentration of 1.5%, which is equal to 12.1 mm and the coconut shell liquid smoke hand sanitizer gel preparation meets the test evaluation. Then a basic combination of galactomannan and carbopol 940 can be obtained used as a base for hand sanitizer gel because it can make hand sanitizer gel becomes thick. Conclusion: coconut shell liquid smoke can be formulated into hand sanitizer gel preparations, galactomannan can be used as a base for hand sanitizer gel

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