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PENGARUH KRIM EKSTRAK UBI UNGU (Ipomoea Batatas Var Ayumurasaki) TERHADAP MATRIKS METALLOPROTEINASE-1 DAN JUMLAH KOLAGEN DERMIS TIPE-I DAN TIPE-III (Penelitian Eksperimental Pada Mencit BALB/c yang Dipapar Sinar UV-B) Yukke Nilla Permata; Atina Hussaana; Chodidjah Chodidjah
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 7, No 1 (2021): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Tunas Medika Jurnal Kedokteran & Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

ABSTRAKLatar Belakang : Ubi ungu (Ipomoea Batatas Var Ayumurasaki) terbukti sebagai antiaging karena kandungan antosianin yang bersifat sebagai antioksidan. Antosianin termasuk antioksidan kuat yang dapat melindungi kulit dari radikal bebas. Penelitian mengenai mekanisme kerja ubi ungu ini masih terbatas.Tujuan : untuk mengetahui pengaruh krim ekstrak ubi ungu terhadap ekspresi MMP-1 dan Jumlah Kolagen Tipe-I dan Tipe-III.Metode : Penelitian eksperimental menggunakan post test randomized control group design. Dilakukan pada 24 ekor mencit BALB/c yang dibagi 4 kelompok uji. Semua kelompok dipapar dengan sinar UV-B dengan dosis 1 MED (8 menit). Kelompok Kontrol (K) diolesi dengan basis krim, sedangan tiga kelompok perlakuan lainnya diolesi dengan krim ekstrak ubi ungu dengan dosis 0,4%(P1), 4%(P2), dan 40%(P3) segera setelah paparan UV-B yang dilakukan selama 4 minggu. Ekspresi MMP-1 dihitung dari jumlah total fibroblast yang mengekspresikan MMP-1. Ekspresi MMP-1 dan Jumlah Kolagen Tipe-I dan Tipe-III dilakukan dengan pengecatan imunohistokimia. Ekspresi MMP-1 dianalisis dengan One Way Anova dan Post hoc pada tingkat kemaknaan p<0,05Hasil : Ekspresi MMP-1 antara kelompok K, P1, P2, dan P3 berturut-turut adalah (40,164,62), (35,833,06), (28,162,78), (18,502,42) memiliki perbedaan signifikan (p<0,05). Jumlah Kolagen Tipe-I antara kelompok K, P1, P2, dan P3 berturut-turut adalah (48,674,58), (55,504,80), (64,333,55), (67,504,18) memiliki perbedaan signifikan (p<0,05). Jumlah Kolagen Tipe-III antara kelompok K, P1, P2, dan P3 berturut-turut adalah (11,831,32), (16,160,98), (19,671,36), (22,001,09) memiliki perbedaan yang signifikan antar kelompoknya (p<0,05).Kesimpulan : krim ekstrak ubi ungu berpengaruh terhadap ekspresi MMP-1 dan Jumlah Kolagen Tipe-I dan Tipe-III pada mencit BALB/c yang dipapar sinar UV-B.Kata kunci : Ubi Ungu, MMP-1, Jumlah Kolagen Tipe-I, Jumlah Kolagen Tipe-IIIABSTRACTPurple sweet potato (Ipomoea Batatas Var Ayumurasaki) is proven to be antiaging because of it is anthocyanin content which is an antioxidant. The antioxidant effects of anthocyanins include powerful antioxidants that protect the skin from free radicals. The mechanism of purple sweet potato's work on the expression MatrixMetalloproteinase-1 (MMP-1) and the Number of Type-I and Type-III Collagen is still limited. The purpose of this study was to determine the purple sweet potato extract cream on expression of MMP-1 and Number of Type-I and Type-III Collagen.Experimental research using randomized control group design post test. Performed in 24 mice BALB/c were divided four groups test. All groups were exposed to UV-B rays at a dose of 1 MED (8 minutes). The Control Group (K) spread with a base cream, while the other three groups were smeared with cream of purple sweet potato extract at a dose of 0.4% (P1), 4% (P2), and 40% (P3) immediately after exposure to UV-B for four weeks. Expression of MMP-1 was calculated from the total from fibroblasts cells that express MMP-1. Expression of MMP-1 and Number of Type-I and Type-III Collagen by immunohistochemical staining. Expression of MMP-1 was analyzed by One Way Annova and Post hoc at a significance level of p <0.05Expression of MMP-1 between group C, P1, P2, and P3 are (40.16 4.62), (35.83 3.06), (28.16 2.78), (18.50 2.42) had a significant difference (p <0.05). Number of Type-I Collagen between group C, P1, P2, P3 are (48.67 4.58), (55.50 4.80), (64.33 3.55), (67.50 4.18) had a significant difference (p <0.05). Number of Type-III Collagen between groups C, P1, P2, P3 are (11.83 1.32), (16.16 0.98), (19.67 1.36), (22.00 1.09) had a significant difference between groups (p <0.05).The conclusion of this study is the purple sweet potato extract cream effects on the expression of MMP-1 and the number of Type-I and Type-III Collagen in BALB /c mice were exposed to UV-B rays.Keyword : Purple sweet potato, MMP-1, Number of Type-I Collagen, Number of Type-III Collagen

Hubungan Kepatuhan Terapi terhadap Lesi Kulit dan Kualitas Hidup Pasien Dermatitis Atopik di Rumah Sakit Umum Daerah Waled Kabupaten Cirebon Aurora Nurfauziyyah Nabiilah Fatimatuzah; Rama Samara Brajawikalpa; Yukke Nilla Permata
Malahayati Nursing Journal Vol 8, No 2 (2026): Volume 8 Nomor 2 (2026)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v8i2.22213

ABSTRACT Atopic dermatitis is a chronic relapsing condition that requires long-term therapy. Therefore, treatment success greatly depends on the patient’s adherence to therapy in order to prevent recurrence and improve quality of life. To assess the correlation between treatment adherence, skin lesion severity, and quality of life in patients with atopic dermatitis at Waled Regional General Hospital, Cirebon Regency. This was an analytical observational study with a cross-sectional design. Participants were patients aged 17–65 years who met the inclusion criteria. Data were collected using a treatment adherence questionnaire, the Dermatology Life Quality Index (DLQI), and the SCORAD index to assess lesion severity. Spearman’s rank correlation test was used to analyze the relationships between variables. A significant negative correlation was found between treatment adherence and lesion severity p 0,000 r = -0,580, as well as between adherence and quality of life p 0,000 r = -0,793. Treatment adherence is significantly associated with reduced lesion severity and improved quality of life in patients with atopic dermatitis. Educational interventions and continuous adherence monitoring are essential in the management of this chronic condition. Keywords: Atopic Dermatitis, Treatment Adherence, Skin Lesions, Quality of Life, SCORAD, DLQI. ABSTRAK Dermatitis atopik memiliki karakteristik penyakit kronis residif yang memerlukan terapi jangka panjang sehingga keberhasilan terapi sangat ditentukan oleh tingkat kepatuhan pasien dalam menjalani pengobatan untuk mencegah kekambuhan dan peningkatan kualitas hidup. Mengetahui hubungan antara kepatuhan terapi dengan lesi kulit dan kualitas hidup pasien dermatitis atopik di RSUD Waled, Kabupaten Cirebon. Penelitian observasional analitik dengan pendekatan cross-sectional. Subjek penelitian adalah pasien dermatitis atopik berusia 17–65 tahun yang memenuhi kriteria inklusi. Data diperoleh melalui kuesioner kepatuhan, instrumen Dermatology Life Quality Index (DLQI), dan penilaian keparahan lesi menggunakan skor SCORAD. Hubungan antar variabel dianalisis menggunakan uji korelasi Rank Spearman. Terdapat hubungan yang signifikan antara kepatuhan terapi dan lesi kulit dengan nilai p = 0,000 dan r = -0,580. Selain itu, terdapat korelasi yang signifikan antara kepatuhan terapi dan kualitas hidup dengan nilai p = 0,000 dan r = -0,793. Terdapat hubungan signifikan antara kepatuhan terapi dengan lesi kulit dan peningkatan kualitas hidup pasien dermatitis atopik. Intervensi edukatif dan monitoring kepatuhan terapi diperlukan dalam manajemen penyakit ini. Kata Kunci: Dermatitis Atopik, Kepatuhan Terapi, Lesi Kulit, Kualitas Hidup, SCORAD, DLQI.

Gambaran Karakteristik Pasien Fibroadenoma Mammae di RSD Gunung Jati Cirebon Periode 2022-2024 Claudia Valensia Oktaviana; Yukke Nilla Permata; Asih Ambarsari
Malahayati Nursing Journal Vol 8, No 6 (2026): Volume 8 Nomor 6 (2026)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v8i6.22460

ABSTRACT Fibroadenoma mammae (FAM) was identified as the most common breast lump occurring in young women. FAM was characterized by a firm, rubbery, well-defined, non-tender, and mobile mass. According to data from KEMENKES RI in 2019, there were 28,910 reported cases of FAM, with the highest prevalence found in West Java Province, total 6,109 cases. This study aimed to describe the characteristics of patients diagnosed with FAM at Gunung Jati Cirebon Hospital during the 2022–2024 period, based on age, lump location, number, size, and the presence of pain. A descriptive observational design was utilized. Secondary data were obtained from medical records of patients who met the inclusion criteria. A total sampling technique was applied, and 116 patient records were analyzed. The majority of FAM patients were in the young adult age group (20–44 years), accounting for 57.8%. Most lumps were located in the right breast (51.7%). Solitary lumps were found in 90.5% of cases, with a typical size of 1–5 cm (62.1%). Pain was reported by 63.8% of the patients. FAM cases at Gunung Jati Cirebon Hospital most frequently occurred among young adult women. The typical presentation involved right-sided, solitary lumps, sized 1–5 cm, and accompanied by pain. These findings may serve as a foundation for improving early detection strategies and enhancing public education regarding FAM. Keywords: Fibroadenoma Mammae, Patient Characteristics, Age, Pain, Breast. ABSTRAK Fibroadenoma mammae (FAM) merupakan benjolan payudara yang paling sering terjadi pada wanita usia muda. FAM memiliki karakteristik berupa benjolan padat, kenyal, batas tegas, tidak nyeri, dan dapat digerakkan. Berdasarkan data KEMENKES RI tahun 2019 angka kejadian FAM sebanyak 28.910 kasus, dengan prevalensi tertinggi di provinsi Jawa Barat sebanyak 6.109 kasus. Mengetahui gambaran karakteristik pasien FAM di RSD Gunung Jati Cirebon periode 2022–2024 berdasarkan usia, lokasi, jumlah, ukuran, dan nyeri. Penelitian ini menggunakan desain deskriptif observasional dengan pengambilan data sekunder dari rekam medis pasien FAM yang memenuhi kriteria inklusi. Teknik sampling yang digunakan adalah total sampling, dengan jumlah sampel sebanyak 116 pasien. Sebagian besar pasien FAM berada pada usia dewasa muda (20–44 tahun) sebesar 57,8%. Lokasi benjolan terbanyak terdapat pada payudara dextra (51,7%). Mayoritas pasien memiliki benjolan soliter (90,5%) dengan ukuran umum 1–5 cm (62,1%). Sebanyak 63,8% pasien mengeluhkan adanya nyeri pada benjolan. FAM pada pasien di RSD Gunung Jati Cirebon paling banyak terjadi pada usia dewasa muda, lokasi benjolan di payudara dextra, jumlah benjolan soliter, ukuran benjolan 1-5 cm, dan disertai nyeri. Data ini dapat menjadi dasar dalam peningkatan deteksi dini dan edukasi masyarakat mengenai FAM. Kata Kunci: Fibroadenoma Mammae, Karakteristik Pasien, Usia, Nyeri, Payudara.

Hubungan Usia Dan Kebiasaan Merokok dengan Kejadian Kanker Paru di dAl-Ihsan Bandung Widya Patra Nurisma Septi; Yukke Nilla Permata; Mohamad Romdhoni; Widhy Yudistira Nalapraya
Malahayati Nursing Journal Vol 8, No 11 (2026): Volume 8 Nomor 11 (2026)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v8i11.23247

ABSTRACT Lung cancer remains one of the leading causes of cancer related deaths in Indonesia, with an increasing number of cases each year. Smoking is recognized as the most dominant risk factor, while age also contributes significantly, especially among the elderly. However, studiest that specifically examine the relationship between age and smoking habits with the incidence of lung cancer at the local level are still limited. This study aims to determine the relationship between age and smoking habits with the incidence of lung cancer, and to describe the patient characteristics based on age, smoking history, and histopathological types of lung cancer. This was an observasional analytic study using a cross sectional approach. The study involved 97 patients selected through purposive sampling. Data were collected from questionnaires and medical records at RSUD Al-Ihsan Bandung from April to June 2025. Data were analyzed using the Rank Spearman correlation test. A total of 66% of patients in this study were diagnosed with lung cancer. Most of them aged 45-64 years and classified as heavy smokers. All patients were diagnosed with Non Small Cell Lung Cancer (NSCLC), with adenocarcinoma being the most common subtype. There was no statistically significant relationship between age and the incidence of lung cancer (p = 0,511), but a statistically significant relationship was found between smoking habits and the incidence of lung cancer (p = 0,046). Conclusion: Smoking habits are significantly associated with the incidence of lung cancer, while age does not show a statistically significant relationship. Keywords: Age, Smoking, Lung Cancer, Adenocarcinoma. ABSTRAK Kanker paru masih menjadi salah satu penyebab utama kematian kanker di Indonesia, dengan jumlah kasus yang terus meningkat dari tahun ke tahun. Merokok dikenal sebagai faktor risiko paling dominan, sementara faktor usia juga turut berperan, khususnya pada kelompok usia lanjut. Meski demikian, kajian yang membahas secara spesifik mengenai hubungan antara usia dan kebiasaan merokok terhadap kejadian kanker paru di tingkat lokal masih jarang ditemukan. Penelitian ini bertujuan untuk mengetahui adanya hubungan antara usia dan kebiasaan merokok dengan kejadian kanker paru, serta mendeskripsikan karakteristik pasien berdasarkan usia, riwayat merokok, dan tipe histopatologi kanker paru. Penelitian ini menggunakan desain observasional analitik dengan pendekatan cross sectional. Jumlah sampel sebanyak 97 pasien yang diperoleh melalui teknik purposive sampling. Penelitian dilakukan di RSUD Al-Ihsan bandung selama periode April hingga Juni 2025. Data dikumpulkan dari kuesioner dan rekam medis, lalu dianalisis menggunakan uji Rank Spearman. Sebanyak 66% pasien dalam penelitian terdiagnosis kanker paru. Mayoritas pasien berusia 45-64 tahun dan memiliki kebiasaan merokok berat. Semua kasus merupakan tipe Non Small Cell Lung Cancer (NSCLC), dengan subtipe adenokarsinoma sebagai yang paling dominan. Tidak ditemukan hubungan yang signifikan antara usia dengan kejadian kanker paru (p = 0,511), tetapi terdapat hubungan bermakna antara kebiasaan merokok dengan kejadian kanker paru (p = 0,046). Kebiasaan merokok berhubungan signifikan dengan kejadian kanker paru, sedangkan usia tidak menunjukkan hubungan yang berarti secara statistik. Kata Kunci: Usia, Merokok, Kanker Paru, Adenokarsinoma

Hubungan Usia, Jenis Kelamin, dan Lokasi Tumor Terhadap Derajat Diferensiasi Histopatologi Pada Kanker Kolorektal di RSD Gunung Jati Cirebon Tahun 2019-2024 Armansyah Armansyah; Yukke Nilla Permata; Dimas Aryo Kusumo
Malahayati Nursing Journal Vol 8, No 11 (2026): Volume 8 Nomor 11 (2026)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v8i11.23249

ABSTRACT Colorectal cancer is one of the most common types of gastrointestinal cancer, with relatively high incidence and mortality rates. Several factors, such as age, gender, and tumor location, are believed to influence the degree of histopathological differentiation associated with patient prognosis. Determine the relationship between age, gender, and tumor location and histopathological differentiation grade in colorectal cancer patients at RSD Gunung Jati Cirebon from 2019 to 2024. This study employed an analytical observational design with a cross-sectional approach. Secondary data were obtained from the medical records of 97 colorectal cancer patients. Spearman's rank test was used to analyze the data and assess the relationship between the variables. Most patients were in the 60+ (47,42%) and 46–59 (38,14%) age groups, and 64.9% were male. The most common tumor location was the rectum (30,9%), followed by the ascending colon (26,8%) and the sigmoid colon (25,8%). The most common histopathological differentiation grade was moderately differentiated (75.26%), while poorly differentiated accounted for 24,74%; no cases of well-differentiated were found. The results of the analysis showed no significant association between age (p = 0,101) or gender (p = 0.439) and histopathological differentiation grade. However, there was a significant association between tumor location and histopathological differentiation grade (p = 0,001). Conclusion: Of the three studied variables, only tumor location showed a significant association with the histopathological differentiation grade of colorectal cancer. Age and gender did not show a significant association. Keywords: Colorectal Cancer, Age, Gender, Tumor Location, Histopathological Differentiation. ABSTRAK Kanker kolorektal merupakan salah satu jenis kanker pada saluran cerna yang memiliki angka kejadian dan kematian yang cukup tinggi. Sejumlah faktor seperti usia, jenis kelamin, dan lokasi tumor diduga berperan dalam menentukan derajat diferensiasi histopatologi yang berhubungan dengan prognosis klinis pasien. Mengetahui hubungan antara usia, jenis kelamin, dan lokasi tumor dengan derajat diferensiasi histopatologi pada kanker kolorektal di RSD Gunung Jati Cirebon tahun 2019–2024. Penelitian menggunakan desain observasional analitik dengan pendekatan potong lintang (cross-sectional). Data diperoleh secara sekunder dari rekam medis 97 pasien kanker kolorektal. Analisis data dilakukan menggunakan uji Rank Spearmen untuk menguji hubungan antar variabel. Mayoritas pasien berada pada kelompok usia 60 tahun (47,42%) dan 46–59 tahun (38,14%), dengan proporsi laki-laki sebanyak 64,9%. Lokasi tumor paling banyak ditemukan di rektum (30,9%), diikuti kolon asendens (26,8%) dan kolon sigmoid (25,8%). Derajat diferensiasi histopatologi paling banyak adalah moderately differentiated (75,26%), sedangkan poorly differentiated sebesar 24,74%, dan tidak ditemukan kasus well differentiated. Hasil analisis menunjukkan bahwa tidak terdapat hubungan yang signifikan antara usia (p = 0,101) maupun jenis kelamin (p = 0,439) dengan derajat diferensiasi histopatologi. Terdapat hubungan yang signifikan antara lokasi tumor dengan derajat diferensiasi histopatologi (p = 0,001). Dari ketiga variabel yang diteliti, hanya lokasi tumor yang menunjukkan hubungan signifikan terhadap derajat diferensiasi histopatologi kanker kolorektal. Usia dan jenis kelamin tidak menunjukkan hubungan yang berarti. Kata Kunci: Kanker Kolorektal, Usia, Jenis Kelamin, Lokasi Tumor, Diferensiasi Histopatologi.

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