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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Majalah Sainstekes ASSYIFA: Jurnal Ilmu Kesehatan
Samsul Mustofa
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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TARGET MOLEKULER UNTUK DESAIN PENGOBATAN PRURITUS NOKTURNAL PADA PASIEN SKABIES: Molecular Target for Treatment Design of Nocturnal Pruritus in Scabies Patients Reqgi First Trasia; Samsul Mustofa; Endang Purwaningsih; Sri Wahyu Herlinawati
ASSYIFA : Jurnal Ilmu Kesehatan Vol. 2 No. 2 (2024)
Publisher : Forind Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62085/ajk.v2i2.76

Abstract

Pruritus is one of the factors that contributes to reduced quality of life in patients with scabies, along with disease severity and sleep disturbances. So far not much is known about the molecular targets in scabies treatment. The aim of this article is to examine the potential of molecular targets for the design of treatment for nocturnal pruritus as the main symptom of scabies. Evidence in various literature correlates the incidence of scabies with a number of targets found in the skin, such as NK1R, JAK, TRPV1 and TRPA1 channels, because the expression of these receptors is very high in the skin lesions of patients suffering from nocturnal pruritus, when compared with skin that does not have lesions. . Results from comparing three molecular targets and considering the development of new therapeutic strategies with structure-based design, NK1R seems to be the most promising due to recent findings of its crystallographic structure.
Diameter Tubulus Seminiferus Dan Tebal Epitel Seminiferus Tikus Jantan (Rattus Norvegicus) Galur Sprague Dawley Setelah Pemberian Ekstrak Aloe Vera Purwaningsih, Endang; Samsul Mustofa; Kuslestari
Majalah Sainstekes Vol. 11 No. 1 (2024): JUNI 2024
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/ms.v11i1.4447

Abstract

Tanaman Aloe vera sering digunakan sebagai bahan baku kosmetik dan sebagai bahan berbagai produk kecantikan serta kesehatan. Pemberian Aloe vera dapat meningkatkan kualitas sepermatozoa dan tidak mempengaruhi berat testis. Perkembangan spermatozoa terjadi di dalam tubulus seminiferus testis. Perubahan diameter tubulus seminiferus dan tebal epitel seminiferus dapat mempengaruhi jumlah sel-sel spermatogenik. Tujuan penelitian adalah mengetahui pengaruh pemberian Aloe vera terhadap diameter tubulus seminiferus dan tebal epitel seminiferus tikus galur Spraque Dawley. Metode penelitian adalah eksperimental murni. Penelitian terdiri atas 4 kelompok tikus, yaitu kelompok kontrol (K) dan 3 kelompok perlakuan ekstrak Aloe vera (P1, dosis 150 mg/kgBB; P2, dosis 200 mg/kgBB, dan P3, dosis 250 mg/kgBB). Subyek penelitian selanjutnya di terminasi, dieksisi dan ditimbang testisnya, kemudian dilakukan preparasi histologi dengan pewarnaan Hematoksilin Eosin. Hasil penelitian menunjukkan rata -rata diameter tubulus seminiferus dari masing-masing kelompok K, P1, P2 dan P3 adalah sebesar 310,003 ± 22,214 µM.; 285,717 ± 7,543 µM, 268,743 ± 19,619 µM, dan 247,303 ±  64,906 µM. Sedangkan tebal epitel seminiferus  setelah perlakuan masing-masing kelompok K, P1, P2 dan P3 adalah sebesar 91,022 ± 3,251 µM; 75,645  ± 4,632 µM;  79,143 ± 2,703 µM, dan 68,560 ± 15,101 µM. Disimpulkan bahwa pemberian Aloe vera dosis 150 -250 mg/kkBB selama satu siklus epitel seminiferus berpengaruh terhadap tebal epitel seminiferus dan tidak berpengaruh terhadap diameter tubulus seminiferus
PHARMACODYNAMIC OF METFORMIN IN TYPE 2 DIABETES MELLITUS PATIENTS: REVIEW OF THE PRKAA2 AND SLC22A3 GENES Sakura Muhammad Tola; Sultana MH Faradz; Ahmad Rusdan Handoyo Utomo; Samsul Mustofa
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 11 No. 3 (2024): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v11i3.462

Abstract

Type 2 diabetes mellitus (type 2 DM) is a disease including on metabolic disorder that characterized by an increase in glucose levels above normal. This glucose increase is caused by reduced insulin function which can be in the form of abnormalities in insulin secretion, impaired insulin action in peripheral tissues, or both. Metformin is one of the recommended therapies for type 2 DM. AMPK is the main pathway of metformin's mechanism. AMPKa2 encoded by PRKAA2 gene is an AMPK subunit that plays an important role in AMPK activation. OCT3 encoded by SLC22A3 plays a role in the metformin transport mechanism. OCT3 is needed in the metformin pharmacokinetic like absorption and elimination, this process determines metformin bioavailability, clearance, and its pharmacological effects. Mutations in PRKAA2 and SLC22A3 cause variations in the pharmacodynamic effects and pharmacokinetic of metformin in individuals directly. These changes will ultimately affect the effectiveness of metformin in type 2 DM patients.
Co-Authors Ahmad Rusdan Handoyo Utomo Endang Purwaningsih Endang Purwaningsih Kuslestari Reqgi First Trasia Sakura Muhammad Tola Sri Wahyu Herlinawati Sultana MH Faradz