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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Majalah Sainstekes Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Yarsi Journal of Pharmacology
Sakura Muhammad Tola
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health

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Corticosteroid in Septic Shock: Advantage or Disadvantage? Sakura Muhammad Tola
Majalah Sainstekes Vol 6, No 2 (2019): DESEMBER 2019
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (66.85 KB) | DOI: 10.33476/ms.v6i2.1198

Abstract

Sepsis has become a major health issue, with more patients dying in hospitals due to sepsis related complications. The pathogenesis of sepsis is complex and involves multiple aspects of the interaction between the infecting microorganisms and the host. Sepsis is fundamentally an inflammatory disease mediated by the activation of the innate immune system. In the case, sepsis is an unbalanced (proinflammatory and anti-inflammatory), dysregulated response, the localized process goes out of control and becomes systemic contribute to diminished oxygen delivery. The process also leads to decreased hemodynamic stability, hyperglycemia and ultimately, multi organ dysfunction syndrome and death in septic shock. The use of corticosteroid hydrocortisone as adjunctive therapy is still debating due to the lack of supporting study and differences result among the studies.
Kajian Penggunaan Antibiotik Spektrum Luas Pada Pasien Intensive Care Unit (ICU) RS. Islam Jakarta Cempaka Putih Selama Periode 1 Januari 2016 – 31 Desember 2016 Putri Ayu Kartika Sari; Sakura Muhammad Tola
Yarsi Journal of Pharmacology Vol. 1 No. 2 (2020): July 2020
Publisher : Bagian Farmakologi, Fakultas Kedokteran Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/yjp.v1i2.2201

Abstract

Latar Belakang: Intensive Care Unit (ICU) merupakan tempat berkembangnya bakteri yang resisten/multiresisten antibiotik. Hal tersebut tejadi karena pasien ICU merupakan pasien yang berada pada kondisi imunokompremais dan penggunaan antibiotik lebih dari satu jenis dalam waktu lama sehingga memudahkan terjadinya transmisi infeksi. Penelitian ini bertujuan untuk mengetahui penggunaan antibiotik spektrum luas pada ICU RSIJ Cempaka Putih periode 1 januari-31 Desember 2016.Metode: Penelitian ini menggunakan studi deskriptif analitik, dengan metode cross-sectional. Data yang digunakan merupakan data sekunder yang diperoleh dari rekam medis pasien.Hasil: Hasil penelitian menunjukkan, dari 100 pasien, pemakaian antibiotik tertinggi yaitu meropenem (28,4%), seftriakson (19,1%), diikuti dengan antibiotik lain. Pola variasi peresepan antibiotik dalam penelitian ini menggunakan 1 jenis sampai >2 jenis antibiotik. Pada hasil sensitivitas uji kultur didapatkan pola resistensi bakteri tertinggi ditemukan yaitu Staphylococcus sp (96%), diikuti Acinetobacter baumanii (91%), Klebsiella sp (81%), dan bakteri lain dengan pola resistensi antibiotik terhadap beberapa antibiotik yaitu terhadap beberapa antibiotik diantaranya seftriakson, meropenem, seftriakson, doripenem, gentamisin, imipenem, eritromisin, seftazidim, dan sefotaksim.Kesimpulan: Penggunaan antibiotik pada pasien ICU RSIJ. Cempaka Putih periode 1 Januari-31 Januari 2016 yang paling banyak adalah meropenem dan seftriakson. Pola resistensi bakteri tertinggi pada pasien ICU RSIJ. Cempaka Putih ditemukan pada Staphylococcus sp (96%) sedangkan untuk antibiotik yang memiliki resistensi tertinggi pada bakteri yaitu eritromisin (95%).
PHARMACODYNAMIC OF METFORMIN IN TYPE 2 DIABETES MELLITUS PATIENTS: REVIEW OF THE PRKAA2 AND SLC22A3 GENES Sakura Muhammad Tola; Sultana MH Faradz; Ahmad Rusdan Handoyo Utomo; Samsul Mustofa
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 11 No. 3 (2024): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v11i3.462

Abstract

Type 2 diabetes mellitus (type 2 DM) is a disease including on metabolic disorder that characterized by an increase in glucose levels above normal. This glucose increase is caused by reduced insulin function which can be in the form of abnormalities in insulin secretion, impaired insulin action in peripheral tissues, or both. Metformin is one of the recommended therapies for type 2 DM. AMPK is the main pathway of metformin's mechanism. AMPKa2 encoded by PRKAA2 gene is an AMPK subunit that plays an important role in AMPK activation. OCT3 encoded by SLC22A3 plays a role in the metformin transport mechanism. OCT3 is needed in the metformin pharmacokinetic like absorption and elimination, this process determines metformin bioavailability, clearance, and its pharmacological effects. Mutations in PRKAA2 and SLC22A3 cause variations in the pharmacodynamic effects and pharmacokinetic of metformin in individuals directly. These changes will ultimately affect the effectiveness of metformin in type 2 DM patients.
PERITONITIS BAKTERIAL SPONTAN DAN PENGARUH PENGHAMBAT POMPA PROTON PADA PENDERITIA SIROSIS HATI Lelosutan, Syafruddin; Sakura Muhammad Tola; Intan Keumala Dewi; Endah Purnamasari; Diniwati Mukhtar; Muhammad Samsul Mustofa; Himmi Marsiati
Medika Alkhairaat: Jurnal Penelitian Kedokteran dan Kesehatan Vol 6 No 3 (2024): Desember
Publisher : Fakultas Kedokteran Universitas Alkhairaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31970/ma.v6i3.224

Abstract

Abstract. Spontaneous bacterial peritonitis (SBP) is an acute infection of ascitic fluid in the abdominal cavity (ACAF - ascitic fluid that accumulates in the abdominal cavity) in patients with portal hypertension who experience ascites and is a serious complication of internal medical emergencies in patients with Liver cirrhosis (SH) and nephrotic syndrome (SN). A pathophysiological condition that may be contaminating, such as contamination of dialysate fluid in patients with chronic renal failure (CKD) who receive peritoneal dialysis (PD) or that stimulates the transmission of germs, such as long-term use of proton pump inhibitors (PPI) in SH sufferers, could be an infectious etiology. The pathophysiology of SBP in SH is an inoculation of bacteria in the form of intestinal organisms in ACAF which most likely (> 90%) comes from bacterial contamination due to transmission of germs from the gastrointestinal tract in the presence of enteric microorganism endotoxin which is a direct transmural migration (DTM) of hollow and solid organ bacteria. stomach (gastrointestinal system / esophago-gastro-duodenalis, small and large intestines and pancreatic-hepato-biliary system / pancreas, liver, gallbladder and its ducts); known as enteric bacterial translocation (EBT). Understanding the pathophysiological process of SBP is generally not paid much attention by clinical practitioners, let alone understanding what types of germs are in ascitic fluid. This can be seen from the rare critical assessment (culture and cytology) of the existing ascitic fluid, perhaps even thinking about the presence or absence of ascites at the start of a case of liver cirrhosis (SH). General results show that SH patients who receive PPI therapy appear to experience SBP more often than those who do not receive PPI therapy in their treatment. This review aims to be a critical review of the use of PPIs in liver cirrhosis sufferers to warn of the risk of germ migration from the gastrointestinal tract to ascitic fluid which might cause SBP. Study and understand the literature relating to the management of SBP and the risks of using PPIs in liver cirrhosis sufferers. Gain an understanding of the risks of using PPIs in liver cirrhosis sufferers.
Co-Authors Ahmad Rusdan Handoyo Utomo Diniwati Mukhtar Endah purnamasari Himmi Marsiati Intan Keumala Dewi Lelosutan, Syafruddin Muhammad Samsul Mustofa Putri Ayu Kartika Sari Samsul Mustofa Sultana MH Faradz