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All Journal ALKIMIA : Jurnal Ilmu Kimia dan Terapan Rafflesia Journal of Natural and Applied Sciences (RJNAS)
Desta Amelia
Universitas Islam Negeri Raden Fatah Palembang
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Skrinning Fitokimia Dan Uji Toksisitas Daun Kundur (Benincasa hispida) Dengan Metode Brine Shrimp Lethality Test (BSLT) : Skrinning Fitokimia Dan Uji Toksisitas Daun Kundur (Benincasa hispida) Dengan Metode Brine Shrimp Lethality Test (BSLT) Dwi fitri yani dwi; Salsabila; Amelia Nur Haliza; Desta Amelia; Lika Okta Pristiwi; Tegar
RAFFLESIA JOURNAL OF NATURAL AND APPLIED SCIENCES Vol. 4 No. 1 (2024): April
Publisher : UNIB Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/rjna.v4i1.34652

Abstract

Tanaman Kundur (Benincasa hispida) termasuk ke dalam golongan Cucurbitaceae, danseringkali dimanfaatkan dalam pengobatan tradisional. Hal ini disebabkan kandungan senyawa metabolitsekunder di dalamnya. Namun dalam beberapa penelitian, tanaman ini lebih menfokuskan padakandungan yang ada dalam buah dan biji. Penelitian ini dilakukan untuk mengetahui efek toksik dariekstrak etanol daun kundur dengan menggunakan metode BSLT yang menggunakan larva Artemiadengan pengamatan 1 x 24 jam. Hasil fitokimia menyatakan daun kundur mengandung senyawa antaralain terpenoid, flavonoid, alkaloid, dan saponin, dengan nilai LC50 sebesar 735,79 ppm yangdikategorikan berpotensi toksik dan dapat digunakan dalam aktivitas antikanker
Isolation and identification of Endophytic Fungi from Passiflora foetida L. and Evaluation of Anticholesterol Activity Leni Legasari; Suci Permata Sari; Desta Amelia; Astri Windari; Sherly Ananda Ferga; Damayanti Iskandar; Yulian Syahputri
ALKIMIA Vol 10 No 2 (2026): ALKIMIA (IN PRESS)
Publisher : SCIENCE AND TECHNOLOGY FACULTY OF UNIVERSITAS ISLAM NEGERI RADEN FATAH PALEMBANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/tp9e0a83

Abstract

Hypercholesterolemia is a major cause of many cardiovascular and other degenerative diseases. Thus, more studies are required to discover natural sources of anticholesterol compounds. This study examined the isolation and characterization of endophytic fungi from rambusa leaves (Passiflora foetida L.) and the anticholesterol activity of endophytic fungi associated with these leaves. The endophytic fungi were separated and grown on dextrose potato agar and dextrose potato broth. The fungi were extracted with ethyl acetate and then tested with phytochemical analysis and gas chromatography-mass spectrometry (GC-MS) analysis. Fungal extracts were then studied, and anticholesterol tests were carried out using a modified Zak method. This study isolated four endophytic fungal isolates, with two fungal isolates,Colletotrichum sp., andBotrytis sp., having higher extract yields, and were selected for further testing. Further phytochemical analysis confirmed the presence of flavonoids, alkaloids, and tannins. GCMS analysis also showed the content of several fatty acid derivatives, esters, and other compounds containing amino and hydroxyl functional groups. In vitro anticholesterol test results showed that isolate Botrytis sp. had a greater effect on cholesterol reduction (24.46-39.50%) compared to Colletotrichum sp (14.16-25.17%). The results obtained provide insight into the potential of the endophytic fungiBotrytis sp. as an anticholesterol agent.
Co-Authors Amelia Nur Haliza Astri Windari Damayanti Iskandar Dwi fitri yani dwi Leni Legasari Lika Okta Pristiwi Salsabila Sherly Ananda Ferga Suci Permata Sari Tegar Yulian Syahputri