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All Journal Journal of General-Procedural Dermatology & Venereology Indonesia Indonesian Journal of Biomedicine and Clinical Sciences
He Yeon Asva Nafaisa
Dermatology And Venereology Department, Faculty Of Medicine, Public Health And Nursing Universitas Gadjah Mada, Yogyakarta/ Dr. Sardjito Central General Hospital, Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Administration of vitamin D3 topical in increasing serum vitamin D level: A literature review Nafaisa, He Yeon Asva; Waskito, Fajar; Martien, Ronny; Danarti, Retno
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Vitamin D is an essential fat-soluble vitamin that is required daily by the body. Deficiency in vitamin D is experienced by most of the world's population. Vitamin D plays a role in maintaining the skin barrier by regulating keratinocyte proliferation and differentiation, promoting filaggrin formation, and intraepidermal lipids. Discussion: The vital role of vitamin D, non-compliance with supplement consumption, and poor nutritional status of adult patients and the elderly with deficiency and insufficiency of vitamin D encourage studies regarding vitamin D delivery via the transdermal route. The lipophilicity of vitamin D allows it to penetrate through the skin barrier. Conclusion: Research indicates that topical application of vitamin D3 is not only safe but also effective in increasing serum vitamin D levels. Thus, topical delivery is a promising alternative method for providing vitamin D supplementation or as a therapeutic option for specific conditions that leads to improved skin hydration and serum vitamin D levels.
The effectiveness of topical vitamin D3 for dry skin in elderly Nafaisa, He Yeon Asva; Waskito, Fajar; Martien, Rony; Danarti, Retno
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 01 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i01.11961

Abstract

Dry skin is one of the most common dermatoses found in the elderly. Vitamin D is an essential fat-soluble vitamin that has a role in repairing the skin barrier. Topical administration of vitamin D3 is expected to increase skin hydration in the elderly. Thirty-two participants were divided into two groups, namely 5000 IU vitamin D3 and the base lotion groups. The assessment was carried out by calculating the overall dry skin score (ODS), transepidermal water loss (TEWL), and skin capacitance every 4 wk for 12 wk. All groups showed an improvement in ODS, a decrease in TEWL, and an increase in skin capacitance value at the end of the measurement, and no significant side effects were reported. The 5000 IU vitamin D3 lotion group had the highest level of skin hydration compared to the other group (p>0,05). We conclude that the administration of 5000 IU vitamin D3 lotion may be administrated safely and improve skin hydration in the elderly but is not more effective than base lotion.
Co-Authors Fajar Waskito Martien, Rony Ronny Martien