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The Role of Cervical Erosion on Vaginal Colonization of Candida sp. Study on the Intrauterine Contraceptive Device Users in Puskesmas Depok I Sleman Satiti Retno Pudjiati, Erni Setyawati, Fajar Waskito
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 02 (2009)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Background: Candida sp is an opportunistic pathogenic yeast causing clinical diseases such as vulvovaginal candidiasis (VVC) under certain circumstances. Availability of erythrocytes in the vagina, as in cervical erosion, creates an ideal niche for yeast possessing erythrocyte-binding surface receptors to enhance colonization of Candida sp. Objective: To compare the number of vaginal Candida sp colonies among IUD users with and without cervical erosion. Methods: It was a cross-sectional study involving 45 IUD users. Subjects were classified into cervical erosion group and without cervical erosion group, who underwent vaginal lavage to obtain vaginal fluid samples. Candida sp were grown by inoculating 0.1 ml of vaginal fluid samples into CEA culture media and incubated at 25Â°C-30Â°C for 48 hours. Candida sp would grow as round and smooth colonies in blackish-brown color. The numbers of colonies (cfu/ml) in each CEA disk were measured manually, and multiplicated with the factors of dilution. Data were numeric variables, and analyzed with Students t-test. Results: Average number of Candida sp colonies in the group with cervical erosion was 154.25:t 102.61 cfulml, while that in the group without cervical erosion was 47.00:t 39.08 cfulml. Conclusion: Average number of Candida sp colonies in IUD users with cervical erosion was significantly higher than in IUD users without cervical erosion (p < 0.05). Key words: cervical erosion - Candida sp - VVC - yeast possessing erythrocyte-binding receptors -IUD

Prevalence and risk factors of hand dermatoses among pandan handicrafters Fajar Waskito, Erni Setiyawati Devi Artami S, Sri AwaliaFebriana,
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 03 (2008)
Publisher : Universitas Gadjah Mada

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Background: Pandan handicraft is one of the industrial sectors which has a significant role in employing people in Kulonprogo, Yogyakarta. Development in this industry makes higher material exposure to the hands during the production procedures, that makes it essential to study the risk of suffering from hand dermatoses among the handicrafters.Objective: To determine the prevalence and risk factors of hand dermatoses among pandan handicrafters. Methods: Cross-sectional study was conducted on 80 subjects who was taken randomly from Pandan handicrafter population in Tanjungharjo village, Kulonprogo, Yogyakarta. Prevalence data were analyzed descriptively. Risk factors were analyzed using estimation of prevalence ratio (pr), 95% Confident Interval (el), and chi-square test.Results: Out of 74 subjects fulfilled the criteria, 58 (78.4%) were suffered from hand dermatoses. Callus was the most common disease occurred in 49 (66.2%) subjects, followed by irritant contact dermatitis (lCD) in 18 (24.3%) subjects. History of atopy was proven as risk factor for ICD (p = 0.025, pr = 2.872; 95%el = 0.913-9.032). Types and duration of work were not proven as risk factors, as well as no gloves protection during work.Conclusion: Callus was the most common hand dermatosis occurred among pandan handicrafters, followed by ICD. History of atopy was identified as a risk factor for ICD.Key words : pandan - handicrafter - hand dermatosis - occupational-atopy

HUBUNGAN ANTARA PENDAMPING PERSALINAN, UMUR DAN PARITAS IBU HAMIL DENGAN TINGKAT KECEMASAN IBU HAMIL MENJELANG PERSALINAN DI KLINIK KESEHATAN IBU DAN ANAK PUSKESMAS MABELOPURA KECAMATAN PALU SELATAN SULAWESI TENGAH Halim Musahib, Abd; Waskito, Fajar; Syamsi, Nur
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 1 No. 1 (2015)
Publisher : Universitas Tadulako

LatarBelakang: Di Dunia, dua ratus juta perempuan hamil dengan berbagai risiko kehamilan dijumpai setiap tahun. Komplikasi yang disebabkan faktor risiko dalam masa kehamilan sebesar 40%, salah satunya adalah kecemasan. Beberapa faktor penyebab kecemasan pada ibu hamil menjelang persalinan adalah usia, paritas, pendamping persalinan dan pengetahuan tentang persalinan.Tujuan: Mengetahui hubungan antara usia, paritas, dan pendamping ibu hamil dengan Tingkat Kecemasan Ibu Hamil Menjelang PersalinanMetode: Desain penelitian adalah cross sectional dengan jumlah subjek sebanyak 59 orang yang dipilih menggunakan accidental sampling.Hasil: Penelitian menunjukan bahwa faktor adanya pendamping persalinan secara statistik mempunyai hubungan bermakna untuk terjadinya kecemasan pada ibu hamil menjelang persalinan (CI 95%, p = 0,000), sedangkan faktor usia dan jumlah paritas secara statistik tidak mempunyai hubungan bermakna (CI 95%, p = 0,378 dan p = 0,115)Kesimpulan: Pada ibu hamil menjelang persalinan, pendamping persalinan merupakan faktor risiko untuk terjadinya kecemasan, sedangkan usia dan jumlah paritas ibu tidak merupakan faktor risiko untuk terjadinya kecemasan.

The Role of Cervical Erosion on Vaginal Colonization of Candida sp. Study on the Intrauterine Contraceptive Device Users in Puskesmas Depok I Sleman Erni Setyawati, Fajar Waskito Satiti Retno Pudjiati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 02 (2009)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Candida sp is an opportunistic pathogenic yeast causing clinical diseases such as vulvovaginal candidiasis (VVC) under certain circumstances. Availability of erythrocytes in the vagina, as in cervical erosion, creates an ideal niche for yeast possessing erythrocyte-binding surface receptors to enhance colonization of Candida sp. Objective: To compare the number of vaginal Candida sp colonies among IUD users with and without cervical erosion. Methods: It was a cross-sectional study involving 45 IUD users. Subjects were classified into cervical erosion group and without cervical erosion group, who underwent vaginal lavage to obtain vaginal fluid samples. Candida sp were grown by inoculating 0.1 ml of vaginal fluid samples into CEA culture media and incubated at 25°C-30°C for 48 hours. Candida sp would grow as round and smooth colonies in blackish-brown color. The numbers of colonies (cfu/ml) in each CEA disk were measured manually, and multiplicated with the factors of dilution. Data were numeric variables, and analyzed with Student's t-test. Results: Average number of Candida sp colonies in the group with cervical erosion was 154.25:t 102.61 cfulml, while that in the group without cervical erosion was 47.00:t 39.08 cfulml. Conclusion: Average number of Candida sp colonies in IUD users with cervical erosion was significantly higher than in IUD users without cervical erosion (p < 0.05). Key words: cervical erosion - Candida sp - VVC - yeast possessing erythrocyte-binding receptors -IUD

Prevalence and risk factors of hand dermatoses among pandan handicrafters Erni Setiyawati Devi Artami S, Sri AwaliaFebriana, Fajar Waskito
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 03 (2008)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Background: Pandan handicraft is one of the industrial sectors which has a significant role in employing people in Kulonprogo, Yogyakarta. Development in this industry makes higher material exposure to the hands during the production procedures, that makes it essential to study the risk of suffering from hand dermatoses among the handicrafters.Objective: To determine the prevalence and risk factors of hand dermatoses among pandan handicrafters. Methods: Cross-sectional study was conducted on 80 subjects who was taken randomly from Pandan handicrafter population in Tanjungharjo village, Kulonprogo, Yogyakarta. Prevalence data were analyzed descriptively. Risk factors were analyzed using estimation of prevalence ratio (pr), 95% Confident Interval (el), and chi-square test.Results: Out of 74 subjects fulfilled the criteria, 58 (78.4%) were suffered from hand dermatoses. Callus was the most common disease occurred in 49 (66.2%) subjects, followed by irritant contact dermatitis (lCD) in 18 (24.3%) subjects. History of atopy was proven as risk factor for ICD (p = 0.025, pr = 2.872; 95%el = 0.913-9.032). Types and duration of work were not proven as risk factors, as well as no gloves protection during work.Conclusion: Callus was the most common hand dermatosis occurred among pandan handicrafters, followed by ICD. History of atopy was identified as a risk factor for ICD.Key words : pandan - handicrafter - hand dermatosis - occupational-atopy

The effect of combination of triamcinolone acetonide and methotrexate on keloidfibroblast activity in dermis equivalent Endra Yustin E. S; Fajar Waskito; Yohanes Widodo Wirohadidjojo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 02 (2008)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Background: Triamcinolone acetonid (TA) intralesion has been a standard treatment for keloids for manyyears, due to its effect in inhibiting collagen synthesis and fibroblast proliferation. However, until now theclinical result is unsatisfactory. Keloid flattening is slow and sometimes adverse reactions may occur.Methotrexate (MTX) is a chemotherapeutic agent having an antiproliferating effect which act as an antifolicacid. Because of this effect, MTX is potential to be used in combination with TA for the treatment inkeloid. Fibroblast populated collagen lattice (FPCL) was a dermal equivalent usually used for fibroblastactivity measurement.Objective: To understand the inhibition of fibroblast keloid activities of MTX in vitro on FPCL contraction,compared to TA and MTX plus TA.Methods: This research used simple parallel multigroups experimental study design, and conducted on thirdpassage keloid fibroblast culture, which was isolated from one patient. Fibroblast was cultivated in collagentype 1 from rat tail (FPCL). Keloid fibroblasts was classified into 16 groups, and treated with 5, 10, 20mM TA, 1.75, 3.5, 7 mM MTX, combination of TA and MTX, and a control negative. FPCL contractionindicating activities of fibroblast was measured using Scion Image software. Mean of FPCL contractionwas analyzed using one way analysis of variance (ANOVA).Results: All treatments could inhibit FPCL contraction until day 2 (p<0.05). The highest inhibition of FPCLwas found in combination of TA 20 mM + MTX 7 mM (p<0.05). The treatment that could inhibit FPCLcontraction until day 3 was only group MTX 3.5 mM + TA 20 mM. This result indicated that a combinationof TA and MTX was stronger in inhibiting keloid fibroblast activities compared with TA and MTX alone.Key words: keloid fibroblast - growth factors - triamcinolone acetonid - methotrexate - FPCL contraction

A Five-Year Review of Adverse Cutaneous Drug Reaction in a Tertiary Care Hospital in Yogyakarta, Indonesia Dyah Ayu Mira Oktarina; Maria Sophiati; Erinda Maharani Rambu Moha; Fajar Waskito; Hardyanto Soebono
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 3 (2021): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.3.2021.150-155

Background: The prevalence of adverse drug reactions is likely to increase, and it is associated with increased usage of various drugs. Adverse Cutaneous Drug Reaction (ACDR) is the most frequent adverse drug reaction (30–45%). In Indonesia, the study on the prevalence of ACDR is still limited. Purpose: This study investigated the prevalence, clinical features, causative agents, and mortality rate of ACDR with a type-IV hypersensitivity reaction among patients attending the Department of Dermatology and Venereology in Dr. Sardjito Hospital, Yogyakarta. Methods: This retrospective study was conducted examining medical records undertaken for five years (2011–2015). Of 68,375 patients medicated in the Department of Dermatology and Venereology, 397 patients were diagnosed as ACDR with a type-IV hypersensitivity reaction. Detailed history, including age, sex, past history, and family history of drug reaction taken by the patient, were obtained. Patch testing was done wherever feasible. Result: Of 68,375 patients, 397 patients were included in ACDR with type-IV hypersensitivity (0.58%), giving a 5% of mortality rate. The mean age of the patients was 40.42 years (±16.30; range 18 to 89 years). The female to male ratio was 1.1: 1. The Maculopapular rash was the most common ACDR manifestation (50.88%), followed by Stevens-Johnson Syndrome (13.85%), Fixed Drug Eruption (12.85%), and Drug Reaction with Eosinophilia and Systemic Symptoms (10.08%). The most common causative agents were beta-lactam (16.55%), NSAIDs (12.18%), and acetaminophen (8.62%). Conclusion: Prescription of those drugs should be considered carefully so the incidence of ACDR can be reduced.

Validity and Reliability Test of Vitiligo Quality of Life Index (VitiQoL) Indonesian Version in Vitiligo Patients Jeffrey Giantoro; Fajar Waskito; Sunardi Radiono
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 1 (2022): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.1.2022.52-58

Background: Vitiligo is a multifactorial skin disorder that causes depigmentation. Vitiligo can affect a patient's quality of life due to aesthetic issue. The prevalence of vitiligo in the world is 0.5 – 1.0%. An instrument for measuring the quality of life that is specific to vitiligo patients in Indonesia is required. Purpose: This study aims to translate the Vitiligo Specific Quality of Life (VitiQoL) questionnaire into Indonesian: and assess the validity and reliability of the Indonesian language VitiQoL as a quality of life instrument. Methods: An observational method with analytical survey and cross-sectional approach was conducted on 48 vitiligo patients at Sardjito General Hospital Yogyakarta in May – September 2021. The research was carried out in 3 stages. The first stage was the translation of VitiQoL into Indonesian and then back into English. The second and third stages were measuring the validity and reliability of the VitiQoL Indonesian version. Result: The validity test using Pearson product moment showed that the average correlation coefficient for each question is 0.683. Reliability test using Cronbach's alpha of 0.924 VitiQoL. VitiQoL has 3 domains, namely limited participation, stigma, and behavior. The correlation of each domain has a value range of 0.756 - 0.918 with a variation of Cronbach's alpha value per item ranging from 0.808 - 0.89. The limited participation domain (84.2%) has the largest contribution to the value of quality of life. Conclusion: The Indonesian language VitiQoL as an instrument with good validity and reliability can be used to measure the quality of life of vitiligo patients in Indonesia.

Analisis Kondisi Rumah, Sosial Ekonomi dan Perilaku sebagai Faktor Risiko Kejadian Frambusia di Kota Jayapura Tahun 2007 R. Indra Boedisusanto, Fajar Waskito, Haripurnomo Kushadiwijaya
Berita Kedokteran Masyarakat (BKM) Vol 25, No 2 (2009)
Publisher : Fakultas Kedokteran Universitas Gadjah Mada

Background: Yaws is caused by spiral bacillus called treponema perteneu. It is a human infectious disease which commonly attacks skin and bones. The prevalence of yaws in Indonesia was less than 1 per 10,000 people but there were places with high prevalence such as Provinces of West Papua, Papua, South East of Sulawesi, Nusa Tenggara Timur and Maluku. The prevalence of yaws in Jayapura Municipality in 2007 was 5.4 per 10,000 people.Objective: To identify risk factors of house condition, social economic factors and behavioral factors of the occurence of yaws at Jayapura Municipality.Method: The study was observational with case control study design. Sample of the study consisted of 84 cases and 84 control subjects. Data were analyzed using computer with 2 x 2 tables and multiple logistic regression tests at 95% significant level.Result: Multivariable analysis showed that three variables were significant risk factors for the occurence of yaws: house condition (occupancy density, OR=2,5, availability of clean water, OR=5.9), and behavior (taking a bath, OR=3.8).Conclusion: Factors of house condition (occupancy density, availability of clean water), social economy (knowledge) and behavior (taking a bath) are dominant risk factors for the occurence hence prevalence of yaws at Jayapura Municipality.Keywords: Yaws, risk factors, Jayapura Municipality

Allergen profile of facial ACD to cosmetics among patients at Tertiary Referral Hospital in Yogyakarta Alfieri, Alessandro; Indrastuti, Niken; Febriana, Sri Awalia; Pudjiati, Satiti Retno; Waskito, Fajar
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 6, No. 1
Publisher : UI Scholars Hub

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Background: Cosmetics are a part of life for most of the population and may cause allergic contact dermatitis (ACD), especially on the face, as the primary exposure of cosmetics is on the face area.Methods: This research was conducted retrospectively using secondary data. The research subjects and demographic data were taken from the registered list of patients at Dermatology and Venereology Outpatient Clinic Dr. Sardjito General Hospital with a clinical picture of facial ACD due to cosmetics. Patch tests were carried out from January 2017 to December 2020.Results: From three years period, 26 patients were diagnosed with suspected facial ACD due to cosmetics and underwent patch tests. Of the total 26 patients, 3 patients did not show any reaction to the patch test. On the 23 patients who had reactions on the patch test, there were 66 points on the skin that showed a reaction to allergens. Of the 66 points, 37 points gave a positive reaction picture, with the most common allergen causing the reaction being cobalt(II) chloride hexahydrate (n=4, 10.8%). Then, from 29 points that gave doubtful reactions, the allergen that caused the most reactions was potassium dichromate 0.5% (n=4, 13,8%).Conclusion: The allergens that most often give a positive or doubtful reaction on the patch test of this study are metal compounds (cobalt and potassium dichromate). This study only looks at the patch test that gives a reaction without looking at the clinical relevance related to cosmetics use.

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