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All Journal Journal of General-Procedural Dermatology & Venereology Indonesia Indonesian Journal of Biomedicine and Clinical Sciences
He Yeon Asva Nafaisa
Dermatology And Venereology Department, Faculty Of Medicine, Public Health And Nursing Universitas Gadjah Mada, Yogyakarta/ Dr. Sardjito Central General Hospital, Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Journal : Journal of General-Procedural Dermatology

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Administration of vitamin D3 topical in increasing serum vitamin D level: A literature review Nafaisa, He Yeon Asva; Waskito, Fajar; Martien, Ronny; Danarti, Retno
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Vitamin D is an essential fat-soluble vitamin that is required daily by the body. Deficiency in vitamin D is experienced by most of the world's population. Vitamin D plays a role in maintaining the skin barrier by regulating keratinocyte proliferation and differentiation, promoting filaggrin formation, and intraepidermal lipids. Discussion: The vital role of vitamin D, non-compliance with supplement consumption, and poor nutritional status of adult patients and the elderly with deficiency and insufficiency of vitamin D encourage studies regarding vitamin D delivery via the transdermal route. The lipophilicity of vitamin D allows it to penetrate through the skin barrier. Conclusion: Research indicates that topical application of vitamin D3 is not only safe but also effective in increasing serum vitamin D levels. Thus, topical delivery is a promising alternative method for providing vitamin D supplementation or as a therapeutic option for specific conditions that leads to improved skin hydration and serum vitamin D levels.
Co-Authors Fajar Waskito Martien, Rony Ronny Martien