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All Journal Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Penyakit Dalam Indonesia
Asicha, Nur
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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Efektivitas dan Keamanan Beraprost untuk Pengobatan Klaudikasio Intermiten pada Critical Limb Threatening Ischemia (CLTI) Pangestu, Andhika; Asicha, Nur; Cahyanur, Rahmat; Resultanti, Resultanti
Jurnal Penyakit Dalam Indonesia Vol. 10, No. 2
Publisher : UI Scholars Hub

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Abstract

Critical limb threatening ischemia (CLTI) is the most advanced stage of peripheral arterial diseases. Alternative treatment for claudication in CLTI patients is beraprost. We aim to review effectiveness and safety beraprost for relieve symptoms in CLTI. We conducted systematic literature searching using PubMed/MEDLINE, Embase, ProQuest, and Cochrane databases. Selected articles were examined for duplication and screened by abstract and title. Then, we appraised the articles based on the critical appraisal sheet from Centre for Evidence-Based Medicine (CEBM) University of Oxford. We found one systematic review-meta analysis (SR-MA) which involved 4,477 randomized participants. The results from this study are moderate quality evidence that prostanoids reduced rest pain (RR 1.30; 95%CI 1.06 – 1.59) and promoted ulcer healing (RR 1.24; 95%CI 1.04 – 1.48). In adult patients with CLTI and intermittent claudication as the primary complaint, vasodilator agents such as beraprost have a beneficial effect and a favorable therapeutic response. Numerous effects, including cardiovascular benefit, adverse events, resting pain relief, ulcer healing, outcome maximum walking distance (MWD), and pain-free walking distance, demonstrate the benefit (PFWD). The benefits of beraprost differ depending on the mechanism of action and pharmacokinetics of the drugs.
Kualitas Hidup Pasien Artritis Reumatoid dan Faktor-Faktor Yang Memengaruhi Hidayat, Rudy; Asicha, Nur; Tahapary, Dicky Levenus; Wibowo, Suryo Anggoro Kusumo
Majalah Kedokteran Indonesia Vol 73 No 2 (2023): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.73.2-2023-1032

Abstract

Introduction: Rheumatoid arthritis (RA) is a rheumatic disease that often results in functional disability and decreased health-related quality of life (HRQoL). This study aims to evaluate the HRQoL and related factors in patients with RA.Method: This study enrolled 152 patients from Rheumatology polyclinic at RSUPN Dr. Cipto Mangunkusumo Jakarta. Sosiodemographic, clinical, and laboratory data related to disease activity, functional status, psychological problems, and number of comorbidities were collected. Disease activity was assessed with cumulative Disease Activity Score-28 with erythrocyte sedimentation rate (DAS28 ESR) for the last 6 months. HRQoL was assessed using the Indonesian EuroQol five-dimensional questionnaire (EQ-5D) and EQ global health visual analogue scale (VAS). Univariate analysis, bivariate and multivariate analysis were employed to identify factors related to HRQoL.Result: Of the enrolled participants, 90.8% were female with a mean age of 49.41 ± 12.31 years. Majority of subjects had moderate disease activity and an independent functional status. Median duration of illness was 3 (0 – 34) years. The study also identified psychological disorders such as anxiety (11.2%) and depression (20.4%). The median EQ-5D index value was 0.84 (0.170 – 1.000), and the median EQ VAS was 70 (40 – 100). Functional disability, disease activity, and depression were independently associated with both the index EQ-5D score and EQ VAS, while anxiety and number of comorbidities were only independently associated with EQ VAS.Conclusion: Functional disability, disease activity, psychological disorders and number of comorbidities negatively impact the HRQoL of RA patients. Hence, evaluation of these factors should be considered in the standard of care for RA patients.
Co-Authors Dicky Levenus Tahapary Pangestu, Andhika Rahmat Cahyanur Resultanti, Resultanti Rudy Hidayat Wibowo, Suryo Anggoro Kusumo