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All Journal International Journal of Public Health Science (IJPHS) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia
Rudy Hidayat
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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Diagnosis and Management of Klatskin Tumor Dicky Levenus Tahapary; Rudy Hidayat; Achmad Fauzi; Marcellus Simadibrata
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 11, NUMBER 1, April 2010
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/111201044-50

Abstract

Klatskin tumor is a cholangiocarcinoma in bifurcatio areas and related to poor prognosis. Surgery is the only curative method, but endoscopy also has a role in diagnostic as well as therapeutic measures. This report shall discuss a case of Klatskin tumor in which to establish diagnosis, multimodal imaging using ultrasonography, computed tomography, endoscopic retrograde cholangiopancreatography (ERCP), and tumor markers were used. For palliative therapeutic measures in this case, placement of plastic stents by ERCP was performed. The procedure ERCP with stents placement can be an option in the management of Klatskin tumor, in which surgery is not possible to be conducted. Keywords: Klatskin tumor, ERCP, stent, diagnosis, management
Correlation between Rheumatoid Factor and Vascular Cell Adhesion Molecule-1 Levels in Rheumatoid Arthritis Patients Without Metabolic Syndrome Yogaswara, Reza; Hidayat, Rudy; Muhadi, Muhadi; Rinaldi, Ikhwan
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 2
Publisher : UI Scholars Hub

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Risiko Kardiovaskuler pada Pasien Artritis Reumatoid Hidayat, Rudy
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 2
Publisher : UI Scholars Hub

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Pengaruh Terapi Metotreksat pada Pasien Artritis Reumatoid terhadap Penurunan Fungsi Kognitif: Meta-Analisis Berdasarkan Telaah Sistematik Fauzia, Fara; Prihartono, Nurhayati Adnan; Hidayat, Rudy; Araminta, Abirianti P.
Jurnal Penyakit Dalam Indonesia Vol. 10, No. 2
Publisher : UI Scholars Hub

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Introduction. Rheumatoid arthritis (RA) is a systemic and chronic autoimmune disease involving the joints disorder as the main manifestations. Methotrexate (MTX) is currently still the drug of choice for RA treatment due to the good clinical response. However, there was a case reported by the American Geriatric Society in 2015 regarding the presence of reversible dementia after treatment with low-dose oral methotrexate. This study aimed to identify the effect of MTX treatment on cognitive disorder in RA patients. Methods. The study protocol was registered with PROSPERO (CRD42023414937). A systematic literature search was conducted in Medline Embase database, Scopus, CENTRAL to identify cohort observational studies, case controls, and randomized control trial (RCT) studies, evaluating the effect of methotrexate therapy on cognitive function disorder in RA patients. The Newcastle-Ottawa Scale (NOS Scale) was used to analyze the quality of existing observational studies and The COCHRANE was used to analyze the RCT studies which included in the journals reviewed. Results. There were 4 observational studies that met the criteria, including 2 case control studies and 2 cohort studies. Pooling was carried out in two different types of studies. The OR was 0.81 (95%CI 0.4 – 1.68) in the case control studies group, whereas the RR was 0.88 (95% CI 0 .6 – 1.3) in the cohort studies group. The heterogeneity of each type of case-control studies and cohort studies were I2 92% (p-value277% (p-value Conclusion. Methotrexate therapy has not been proven to have an effect on cognitive disorder in RA patients either as a protective factor or as a risk factor.
Obesity and methotrexate treatment failure in rheumatoid arthritis patients in Cipto Mangunkusumo Hospital, Indonesia Fauzia, Fara; Adnan Prihartono, Nurhayati; C. Adisasmita, Asri; Umi Partan, Radiyati; Djuwita Hatma, Ratna; Hidayat, Rudy
International Journal of Public Health Science (IJPHS) Vol 13, No 3: September 2024
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v13i3.24046

Abstract

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease which mainly manifests in the joints. Methotrexate (MTX) is a widely used pharmacological treatment for RA. To date, no prior research has investigated the effect of obesity on MTX treatment outcomes among RA patients in Indonesia. This research aimed to investigate the effect of obesity on MTX monotherapy failure in RA patients. We conducted a retrospective cohort study using medical records from the Rheumatology Clinic at Cipto Mangunkusumo Hospital from March 2017 to December 2021. Descriptive and estimation analyses were performed to assess the sample characteristics based on each variable and a logistic regression analysis was conducted to evaluate the association between obesity and MTX treatment failure. Out of 72 subjects, the proportion of MTX treatment failure was 57.1% (20/35) among obese patients and 37.8% (14/37) among non-obese patients. Obese subjects exhibited a 2.11-fold increased risk of MTX treatment failure compared to non-obese patients (OR 2.11; 95% CI 0.81-5.45). The number of joints involved was found to emerge as a confounding factor in this study. Our findings suggest that RA patients with obesity potentially have an increased risk of MTX treatment failure compared to non-obese RA patients.
Sarkopenia sebagai Faktor Risiko Varises Esofagus Risiko Tinggi berdasarkan Stratifikasi Child-Pugh Pasien Sirosis Hati Sepmeitutu, Iwandheny; Kurniawan, Juferdy; Maulahela, Hasan; Rinaldi, Ikhwan; Shatri, Hamzah; Pramana, Triyanta Yuli; Makmun, Dadang; Lesmana, Cosmas Rinaldi A; Hidayat, Rudy; Laksmi, Purwita Wijaya; Sunardi, Diana
Jurnal Penyakit Dalam Indonesia
Publisher : UI Scholars Hub

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Background The high prevalence of sarcopenia in chronic liver disease negatively impacts the quality of life and increases the risk of various complications of cirrhosis, one of which is the development of esophageal varices. The aim of this study was to determine the prevalence of sarcopenia in cirrhosis patients based on the severity of liver cirrhosis and to explore the association of sarcopenia with high-risk esophageal varices stratified by Child-Pugh. Methods This observational cross-sectional study involved patients with liver cirrhosis at Cipto Mangunkusumo Hospital between January and September 2023. Sarcopenia was defined as a reduction in muscle mass accompanied by decreased grip strength or walking speed, according to the AWGS 2019 criteria (Asian Working Group for Sarcopenia). Multivariate logistic regression analysis was conducted to evaluate the association between sarcopenia and high-risk esophageal varices. Results A total of 155 patients with liver cirrhosis were included in this study. The majority of liver cirrhosis patients were males, with hepatitis B being the most commonly found etiology. The prevalence of sarcopenia was found in 40.0% of Child-Pugh A patients, 53.8% of Child-Pugh B patients, and 50.0% of Child-Pugh C patients with a p-value of 0.411. The high-risk of esophageal varices was found more frequently in Child-Pugh B (53.8%) and Child-Pugh C (50.0%) compared to Child-Pugh A (25.6%) with a p-value of 0.013. Bivariate analysis showed that the presence of sarcopenia in liver cirrhosis patients has a statistically significant association with an increased risk of high-risk esophageal varices, especially in the Child-Pugh B and C subgroups of liver cirrhosis patients (OR = 7.50 (95% CI: 1.48 – 37.91, p<0.030)). However, no association was found between sarcopenia and high-risk esophageal varices in the Child-Pugh A subgroup (OR = 1.46 (95% CI: 0.65 – 3.29, p<0.477)). Conclusion Sarcopenia significantly increases the risk of high-risk esophageal varices in liver cirrhosis, especially in those with Child-Pugh B and C classification.
Faktor-Faktor Yang Mempengaruhi Keberhasilan Pengobatan Metotreksat Pada Pasien Artritis ReumatoidDA PASIEN ARTRITIS REUMATOID Fauzia, Fara; Prihartono, Nurhayati Adnan; Hidayat, Rudy
Majalah Kedokteran Indonesia Vol 72 No 6 (2022): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.72.6-2022-850

Abstract

Rheumatoid arthritis (RA) is a systemic and chronic autoimmune disease with joint manifestations. Delays in RA treatment will pose a risk of permanent joint damage and increased mortality risk. Diagnosis as early as possible, followed by appropriate therapy, will prevent various complications due to RA, aiming to achieve a condition of remission or minimal low disease activity. The treatment choice for RA is currently a group of disease-modifying anti-rheumatic drugs (DMARDs), with methotrexate (MTX) as the first choice. Various studies have reported various factors that play a role in the success of MTX treatment, including younger age, male sex, normal body mass index, not smoking, early treatment, number of joints involved, inflammatory factors (LED/CRP) and negative serological factors (RF/anti-CCP).
Kualitas Hidup Pasien Artritis Reumatoid dan Faktor-Faktor Yang Memengaruhi Hidayat, Rudy; Asicha, Nur; Tahapary, Dicky Levenus; Wibowo, Suryo Anggoro Kusumo
Majalah Kedokteran Indonesia Vol 73 No 2 (2023): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.73.2-2023-1032

Abstract

Introduction: Rheumatoid arthritis (RA) is a rheumatic disease that often results in functional disability and decreased health-related quality of life (HRQoL). This study aims to evaluate the HRQoL and related factors in patients with RA.Method: This study enrolled 152 patients from Rheumatology polyclinic at RSUPN Dr. Cipto Mangunkusumo Jakarta. Sosiodemographic, clinical, and laboratory data related to disease activity, functional status, psychological problems, and number of comorbidities were collected. Disease activity was assessed with cumulative Disease Activity Score-28 with erythrocyte sedimentation rate (DAS28 ESR) for the last 6 months. HRQoL was assessed using the Indonesian EuroQol five-dimensional questionnaire (EQ-5D) and EQ global health visual analogue scale (VAS). Univariate analysis, bivariate and multivariate analysis were employed to identify factors related to HRQoL.Result: Of the enrolled participants, 90.8% were female with a mean age of 49.41 ± 12.31 years. Majority of subjects had moderate disease activity and an independent functional status. Median duration of illness was 3 (0 – 34) years. The study also identified psychological disorders such as anxiety (11.2%) and depression (20.4%). The median EQ-5D index value was 0.84 (0.170 – 1.000), and the median EQ VAS was 70 (40 – 100). Functional disability, disease activity, and depression were independently associated with both the index EQ-5D score and EQ VAS, while anxiety and number of comorbidities were only independently associated with EQ VAS.Conclusion: Functional disability, disease activity, psychological disorders and number of comorbidities negatively impact the HRQoL of RA patients. Hence, evaluation of these factors should be considered in the standard of care for RA patients.
Co-Authors Achmad Fauzi ACHMAD FAUZI Adiningsih Srilestari Adnan Prihartono, Nurhayati Araminta, Abirianti P. Asicha, Nur Bambang Setyohadi C Rinaldi A Lesmana C. Adisasmita, Asri Christina Simadibrata Dadang Makmun Diana Sunardi Dicky Levenus Tahapary Djuwita Hatma, Ratna Dwi R Helianthi, Dwi R E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Edy R Wahyudi, Edy R Fauzia, Fara Harry Isbagio Hasan Maulahela, Hasan Ikhwan Rinaldi Juferdy Kurniawan Marcellus Simadibrata Marcellus Simadibrata Muhadi Muhadi, Muhadi Prihartono, Nurhayati Adnan Purwita Wijaya Laksmi Sepmeitutu, Iwandheny Siti Setiati Triyanta Yuli Pramana Umi Partan, Radiyati Wibowo, Suryo Anggoro Kusumo Yogaswara, Reza