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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Analis Kesehatan
Wiwin Aprianie
STIKes Borneo Cendekia Medika
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Physics

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Uji Aktivitas Ekstrak Akar Kuning (Arcangelisia flava L. Merr) Sebagai Biospray Anti Nyamuk Aedes aegypti Anggun Mira Bleci Agnes Tepanli; Iqlila Romaidha; Wiwin Aprianie
Jurnal Analis Kesehatan Vol. 15 No. 1 (2026): JURNAL ANALIS KESEHATAN
Publisher : Medical Laboratory Technology Department, Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jak.v15i1.5688

Abstract

Menurut Badan Pusat Statistik (BPS) tahun 2026, angka kesakitan demam berdarah dengue (DBD) di Kalimantan Tengah pada tahun 2025 mencapai 40,84 per 100.000 penduduk. Di Kabupaten Kotawaringin Barat, angka kesakitan DBD mencapai 180,10 per 100.000 penduduk pada tahun 2023, dengan 903 kasus pada tahun 2024 dan 11 kasus pada awal tahun 2025. Penggunaan insektisida kimia secara terus-menerus menyebabkan resistensi sehingga diperlukan alternatif insektisida alami. Akar kuning (Arcangelisia flava L. Merr.) mengandung flavonoid, alkaloid, saponin, tanin, dan triterpenoid yang berpotensi sebagai insektisida. Penelitian ini bertujuan mengetahui efektivitas ekstrak akar kuning pada konsentrasi 10%, 15%, 20%, 25%, dan 30% terhadap nyamuk Aedes aegypti. Penelitian menggunakan desain true experimental dengan pendekatan post-test only control design. Sebanyak 540 nyamuk diuji, masing-masing 20 ekor per kelompok dengan lima kali pengulangan. Hasil penelitian menunjukan mortalitas berturut-turut pada konsentrasi 10%, 15%, 20%, 25%, dan 30% adalah 10%, 13%, 14%, 6%, dan 23%, kontrol positif 75%, sedangkan kontrol negatif 0%. Nilai LC₅₀ sebesar 0,43% (4395,42 ppm) dan uji regresi probit menunjukkan p=0,115 (p>0,05). Disimpulkan bahwa ekstrak akar kuning memiliki aktivitas toksik rendah dan belum optimal sebagai insektisida terhadap Aedes aegypti pada seluruh konsentrasi yang diuji
Synergistic Antibacterial Activity of the Combination Limonene and Salicylic Acid Against Staphylococcus aureus in Atopic Dermatitis Qurrotul A'yun; Wiwin Aprianie; Risti Widya Astuti; Anil Peren Putri Laura
Jurnal Penelitian Pendidikan IPA Vol 12 No 9 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i9.13590

Abstract

Atopic dermatitis increases susceptibility to Staphylococcus aureus colonization, while increasing antibiotic resistance underscores the need for alternative antibacterial agents. This study provides antimicrobial activity and synergistic potential of limonene and salicylic acid—two essential oil components commonly found in Indonesian plants—against S. aureus ATCC 25923. The antibacterial effect was measured using the inhibition zone diameter (IZD) and minimum inhibitory concentration (MIC) assays. Limonene produced the largest inhibition zone at a concentration of 400–500 mg/mL, while salicylic acid showed optimal inhibition at 100 mg/mL. The combination of the two with a 1:9 ratio produced the largest inhibition zone of 20.35 mm, with the volume ratio significantly affecting the IZD value (P < 0.001). The MIC results showed that limonene and salicylic acid had MIC values of 62.5 mg/mL and 6.25 mg/mL, respectively. The 1:9 combination substantially reduced the MIC to 0.12 mg/mL (0.01 mg/mL limonene and 0.11 mg/mL salicylic acid). A FICI value of 0.01 indicates a very strong synergistic effect (FICI ≤ 0.5). Overall, the combination of limonene and salicylic acid demonstrated significantly enhanced antibacterial activity compared to the individual compounds, supporting their potential as a synergistic alternative natural antibacterial for managing S. aureus-associated skin infections
Co-Authors Anggun Mira Bleci Agnes Tepanli Anil Peren Putri Laura Iqlila Romaidha Qurrotul A'yun Risti Widya Astuti