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All Journal Indonesian Journal of Global Health research Indonesian Journal of Global Health Research
Iqlila Romaidha
STIKes Borneo Cendekia Medika
Education Health Professions Languange, Linguistic, Communication & Media Nursing Public Health

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Evaluation of (Tinomiscium petiolare Hook.F. &Thomson) Extract Ointment on Inflammation and Angiogenesis During Incision Wound Healing Larantika Hidayati; Iqlila Romaidha; Anas Fadli Wijaya; Ade Sucipto; Eko Budi Laksono
Indonesian Journal of Global Health Research Vol 7 No 2 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i2.5339

Abstract

Wound incidence remains high worldwide and includes surgical injuries, burns, ulcers and trauma. National reports also show that abrasions and contusions account for more than half of wound complaints. These data indicate a continuing need for effective therapeutic approaches. Wound healing depends on a regulated inflammatory phase and sufficient angiogenesis, and disturbances in these processes can delay tissue repair. Natural compounds with anti-inflammatory and pro-angiogenic activity offer potential support. Tinomiscium petiolare contains flavonoids and alkaloids with documented roles in modulating inflammation and promoting vascular growth. Evidence regarding its effects on incision wounds is limited and requires systematic evaluation. This study aimed to evaluate the wound-healing effects of Tinomiscium petiolare extract ointment by examining inflammatory and angiogenic responses in incision wounds with and without Staphylococcus aureus infection. Twenty-four male Rattus norvegicus were randomized into four groups consisting of non-infected controls, infected controls, extract-treated non-infected rats and extract-treated infected rats. Standardized incision wounds were created, infection was induced in designated groups and the extract ointment was applied to treatment groups. Tissue samples were collected on days 3 and 7 to measure TNF-α expression, macrophage infiltration and blood vessel formation. Statistical analysis included normality testing, variance homogeneity testing and comparative analyses with post-hoc procedures when required. TNF α levels showed no group differences on day 7. Temporal analysis demonstrated significant reductions from day 3 to day 7 in T3 and T4 (p < 0.05). Macrophage infiltration differed among groups (p = 0.044), and post-hoc analysis indicated significantly lower macrophage counts in T4 compared with T1 after Bonferroni correction. Blood vessel density also varied among groups (p = 0.019), and temporal evaluation showed a progressive increase in angiogenesis in T4 from day 3 to day 7, although pairwise comparisons did not reach statistical significance. The extract modulated inflammatory activity and supported angiogenic progression, with the strongest effects in infected wounds treated with the ointment.
Formulation of Gel Extract of Gamat Leaf (Tinomiscium Petiolare Hook.F & Thomson) in Healing of Diabetic Ulcers and Bacterial Inhibitory Power in Rats Mawaqit Makani; Iqlila Romaidha; Olinda Kaulika
Indonesian Journal of Global Health Research Vol. 8 No. 2 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i2.2094

Abstract

Diabetic foot ulcers (DFUs) present a critical clinical challenge, where persistent bacterial infections frequently stall the healing cascade and escalate amputation risks. This delayed recovery is worsened by growing antibiotic resistance against conventional topical agents, underlining an urgent demand for multi target, plant derived alternatives. Although Tinomiscium petiolare Hook.f. & Thomson (locally known as Gamat leaf) is rich in tissue regenerative and antimicrobial compounds, its therapeutic potential in chronic diabetic wound microenvironments has not yet been investigated. This study aimed to formulate Gamat leaf extract (Tinomiscium petiolare) into a gel preparation and evaluate its effectiveness on diabetic ulcer healing and antibacterial inhibitory power in vivo using diabetic rat models. Method: This experimental study included the extraction of Gamat leaves by maceration with 96% ethanol, followed by gel formulation with varying extract concentrations (F1, F2, F3). The bacterial inhibition test was conducted in vitro (well method). The in vivo test used male Wistar rats induced by streptozotocin (STZ) to achieve a diabetic condition, then an excision wound was made as an ulcer model. The parameters observed included physical evaluation of the gel, percentage of wound area shrinkage over 14 days, and bacterial inhibition zone. GC-MS analysis identified dominant bioactive compounds with anti-inflammatory and antioxidant properties. The preparation showed stable viscosity, ensuring optimal adhesion and active ingredient penetration. HE results demonstrated significant increases in collagen deposition and epithelialization compared to the control group. The synergy of chemical, physical, and biological parameters proves that Gamat Leaf is a strong candidate for standardized pharmaceutical ingredients in accelerating wound healing.
Co-Authors Ade Sucipto Anas Fadli Wijaya Eko Budi Laksono Larantika Hidayati Mawaqit Makani Olinda Kaulika