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All Journal MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM Majalah Kedokteran Gigi Indonesia Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry INDONESIAN JOURNAL OF MEDICAL ANTHROPOLOGY
Farmasyanti, Cendrawasih Andusyana
Faculty Of Dentistry, Universitas Gadjah Mada
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Increased TGF-β1 level after cocoa administration during orthodontics tooth movement in Cavia cobaya Fikri, Annisa Nurul; Farmasyanti, Cendrawasih Andusyana; Pudyani, Pinandi Sri
Dental Journal (Majalah Kedokteran Gigi) Vol. 57 No. 2 (2024): June
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v57.i2.p118-123

Abstract

Background: Orthodontic tooth movement (OTM) is a process of tooth movement in the alveolar socket through a bone remodeling process. Cocoa contains caffeine as a bioactive component. The number of studies on the effects of caffeine on orthodontic tooth movement is rising. Purpose: This study aimed to determine the effect of caffeine in cocoa administration on TGF-β1 levels in the pressure side during orthodontic tooth movement. Methods: Twelve Cavia cobaya were divided into 4 groups: control group (ONC), treatment group with 2.3 mg caffeine in cocoa (OWC1), 3.45 mg dose (OWC2) and 4.6 mg dose (OWC3) (n=3). A NiTi open coil spring with light force was applied to two lower incisors tooth of Cavia cobaya. TGF-β1 level in GCF of the pressure side was analyzed using ELISA on days 0, 1, 7, and 14. Data were analyzed using the Two-way ANOVA test (p<0.05) and the LSD Post-Hoc test. Results: Research indicated improvement of TGF-β1 level from the control group with the least average followed group caffeine in cocoa 2.3 mg (OWC1), 3.45 mg (OWC2), and 4.6 mg (OWC3) (p<0.05). Conclusion: This study confirmed that caffeine in cocoa administration increase TGF-β1 level during orthodontics tooth movement on Cavia cobaya in the pressure side.
Co-Authors Ananto Ali Alhasyimi Christnawati Christnawati Darmawan Sutantyo Dewi Sartika Santoso Dyah Karunia Edy Meiyanto Endah Mardiati, Endah Endhira Lentik Rousstia Ervina Sofyanti Fikri, Annisa Nurul Gio, Prana Ugiana Gusti Ayu Made Dwita Hayu Paramesthi Haryono Utomo Heni Susilowati Ida Bagus Narmada Kuijpers-Jagtman, Anne Marie Kuswahyuning Kuswahyuning Kuswayuning Kuswayuning Lidya Noviana Arfiadi Manurung, Prans Samuel Antony Maria Purbiati Marya, Anand Maulani, Adibah Pinandi Sri Pudyani Sari Karuniawati Stephanie Adelia Susanto