Haviz Yuad
Endocrinology And Reproductive Fertility Division, Department Of Obstetrics And Gynecology, Faculty Of Medicine, Andalas University/Dr. M. Djamil Hospital, Padang

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Journal : Syntax Literate: Jurnal Ilmiah Indonesia

Correlation Between Glycated Hemoglobin Levels With Polycystic Ovary Syndrome Phenotypes And Metabolic Syndrome Revivo Rinda Pratama; Haviz Yuad
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (254.589 KB) | DOI: 10.36418/syntax-literate.v7i6.7428

Abstract

Polycystic Ovary Syndrome (PCOS) is one of the endocrine disorders that causes oligo-anovulation, clinical and biochemical signs hyperandrogenism and ovarian- specific morphological signs on ultrasound examination are common in women of reproductive age. Conditions of insulin resistance and hyperandrogenism accompanied by hypertension and obesity can lead to dyslipidemia that can meet the diagnostic criteria for the metabolic syndrome. The American Diabetes Association approved the examination of glycated hemoglobin (HbA1c) levels as a routine screening for impaired glucose tolerance and hyperglycemic conditions. Examination of HbA1c levels using the method Point of Care Test. Several studies have shown a direct correlation between elevated HbA1c levels and complications of PCOS, providing evidence that HbA1c plays a potential role in PCOS. This study aims to determine the correlation between HbA1c levels with PCOS phenotype and metabolic syndrome. The study used an analytical study with a cross sectional analytic study design, the number of samples was 52 respondents. The sample was using selected consecutive sampling and then analyzed for HbA1c levels using POCT, PCOS phenotype, and metabolic syndrome for univariate and bivariate. The study with 52 respondents with PCOS patients, the results showed that the number of respondents with increased HbA1c levels was 17 (32.7%) respondents, most of the respondents with phenotype A were 30 (57.7%) respondents. The number of PCOS respondents with metabolic syndrome was 21 (40.4%) respondents. The results of statistical tests showed that correlation between the PCOS phenotype and HbA1c levels. The proportion of the incidence of metabolic syndrome was higher in respondents with phenotype A than phenotypes B, C, and D. The proportion of metabolic syndrome was higher in the category of elevated HbA1c levels compared to normal HbA1c levels, based on statistical tests there was a correlation between HbA1c levels and metabolic syndrome. Conclusion: There was an increase in HbA1c levels in PCOS patients in this study, which was 32.7% and most of the respondents were with phenotype A. Less than half of the respondents had metabolic syndrome. Statistically, there is a correlation between HbA1c levels and PCOS phenotype in PCOS patients and a correlation between HbA1c levels and metabolic syndrome in PCOS patients..
Congenital Adrenal Hyperplasia In Adolescents Age 18 Years Ibnu Razi Mulya Hasjmy; Dani Kartika Sari; Haviz Yuad
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (178.622 KB) | DOI: 10.36418/syntax-literate.v7i5.6952

Abstract

Congenital adrenal hyperplasia is an autosomal recessive genetic disorder that results in deficiency of enzymes required for steroidogenesis in the cortex of the adrenal glands. The incidence of CAH is rare and it can occur in both males and females. Generally, CYP21 mutations lead to deficiency of the 21-hydroxylase enzyme and failure of adequate cortisol synthesis. Congenital adrenal hyperplasia (CAH) is classified into two types, namely classical and nonclassical types. The patient's clinical manifestation was genital ambiguity in female infants. The aim of this case report is to share our experience of CAH in adolescents in West Sumatera. We report a case of congenital adrenal hyperplasia in an 18 year old girl. The patient was referred to the Urogynecology Obstetrics and Gynecology Department, Dr. M. Djamil Padang with chief complaint of clitoral enlargement since the age of 5 years. On physical examination, vital signs were within normal limits, chest examination revealed Tanner Stage 3 breasts, genital examination revealed an enlarged clitoris with a size of 3x1 cm without the presence of a vaginal canal. Investigations that support the diagnosis are 17-hydroxy progesterone laboratory with a result of 90.2 nmol/L. On ultrasound examination of the abdomen within normal limits with the results of chromosome 46,XX analysis. The patient had not had an adrenal crisis for 18 years. The patient was diagnosed with clitomegaly and the cause of congenital adrenal hyperplasia. The patient was given hydrocortisone therapy at a dose of 20 mg in the morning, followed by a dose of 15 mg at night and planned to undergo clitororeduction surgery by carrying out the perioperative and postoperative hydrocrotisone therapy protocol. The patient's family was given counseling, carried out regular monitoring of the patient and hydrocortisone therapy. Congenital adrenal hyperplasia is a disease caused by genetic disorders that require multidisciplinary management. Enforcement of diagnosis, appropriate management, and counseling are needed to optimize patient growth and development.