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Correlation Between Glycated Hemoglobin Levels With Polycystic Ovary Syndrome Phenotypes And Metabolic Syndrome Revivo Rinda Pratama; Haviz Yuad
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Polycystic Ovary Syndrome (PCOS) is one of the endocrine disorders that causes oligo-anovulation, clinical and biochemical signs hyperandrogenism and ovarian- specific morphological signs on ultrasound examination are common in women of reproductive age. Conditions of insulin resistance and hyperandrogenism accompanied by hypertension and obesity can lead to dyslipidemia that can meet the diagnostic criteria for the metabolic syndrome. The American Diabetes Association approved the examination of glycated hemoglobin (HbA1c) levels as a routine screening for impaired glucose tolerance and hyperglycemic conditions. Examination of HbA1c levels using the method Point of Care Test. Several studies have shown a direct correlation between elevated HbA1c levels and complications of PCOS, providing evidence that HbA1c plays a potential role in PCOS. This study aims to determine the correlation between HbA1c levels with PCOS phenotype and metabolic syndrome. The study used an analytical study with a cross sectional analytic study design, the number of samples was 52 respondents. The sample was using selected consecutive sampling and then analyzed for HbA1c levels using POCT, PCOS phenotype, and metabolic syndrome for univariate and bivariate. The study with 52 respondents with PCOS patients, the results showed that the number of respondents with increased HbA1c levels was 17 (32.7%) respondents, most of the respondents with phenotype A were 30 (57.7%) respondents. The number of PCOS respondents with metabolic syndrome was 21 (40.4%) respondents. The results of statistical tests showed that correlation between the PCOS phenotype and HbA1c levels. The proportion of the incidence of metabolic syndrome was higher in respondents with phenotype A than phenotypes B, C, and D. The proportion of metabolic syndrome was higher in the category of elevated HbA1c levels compared to normal HbA1c levels, based on statistical tests there was a correlation between HbA1c levels and metabolic syndrome. Conclusion: There was an increase in HbA1c levels in PCOS patients in this study, which was 32.7% and most of the respondents were with phenotype A. Less than half of the respondents had metabolic syndrome. Statistically, there is a correlation between HbA1c levels and PCOS phenotype in PCOS patients and a correlation between HbA1c levels and metabolic syndrome in PCOS patients..

Correlation between Glycated Hemoglobin Levels with Polycystic Ovary Syndrome Phenotypes and Metabolic Syndrome Haviz Yuad; Revivo Rinda Pratama
Andalas Obstetrics And Gynecology Journal Vol. 6 No. 2 (2022)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.6.2.138-146.2022

Background: Polycystic Ovary Syndrome (PCOS) is one of the endocrine disorders that causes oligo-anovulation, clinical and biochemical signs hyperandrogenism and ovarian- specific morphological signs on ultrasound examination are common in women of reproductive age. Conditions of insulin resistance and hyperandrogenism accompanied by hypertension and obesity can lead to dyslipidemia that can meet the diagnostic criteria for the metabolic syndrome. The American Diabetes Association approved the examination of glycated hemoglobin (HbA1c) levels as a routine screening for impaired glucose tolerance and hyperglycemic conditions. Examination of HbA1c levels using the method Point of Care Test. Several studies have shown a direct correlation between elevated HbA1c levels and complications of PCOS, providing evidence that HbA1c plays a potential role in PCOS. This study aims to determine the correlation between HbA1c levels with PCOS phenotype and metabolic syndrome. Methods: The study used an analytical study with a cross sectional analytic study design, the number of samples was 52 respondents. The sample was using selected consecutive sampling and then analyzed for HbA1c levels using POCT, PCOS phenotype, and metabolic syndrome for univariate and bivariate. Results: The study with 52 respondents with PCOS patients, the results showed that the number of respondents with increased HbA1c levels was 17 (32.7%) respondents, most of the respondents with phenotype A were 30 (57.7%) respondents. The number of PCOS respondents with metabolic syndrome was 21 (40.4%) respondents. The results of statistical tests showed that correlation between the PCOS phenotype and HbA1c levels. The proportion of the incidence of metabolic syndrome was higher in respondents with phenotype A than phenotypes B, C, and D. The proportion of metabolic syndrome was higher in the category of elevated HbA1c levels compared to normal HbA1c levels, based on statistical tests there was a correlation between HbA1c levels and metabolic syndrome. Conclusion: There was an increase in HbA1c levels in PCOS patients in this study, which was 32.7% and most of the respondents were with phenotype A. Less than half of the respondents had metabolic syndrome. Statistically, there is a correlation between HbA1c levels and PCOS phenotype in PCOS patients and a correlation between HbA1c levels and metabolic syndrome in PCOS patients.

Pregnancy with severe preeclampsia, acute kidney injury and nephrotic syndrome Joserizal Serudji; Haviz Yuad; Syntia Ambelina
Andalas Obstetrics And Gynecology Journal Vol. 7 No. 1 (2023)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.7.1.330-337.2023

Background: Preeclampsia is one of the main causes of maternal death every year. Preeclampsia can have badconsequences for both the mother and the fetus. Complications in the mother in the form of HELLP syndrome(Hemolysis, Elevated Liver Enzyme, Low Platelet), pulmonary edema, kidney disorders, bleeding, placentalabruption and even maternal death. Complications in infants can be premature birth, fetal distress, low birthweight or intra uterine fetal death (IUFD).Case Report: A 34 year old female patient was brought to the emergency room of Dr. M. Djamil Padang, sent tothe Batusangkar Private Hospital with complaints of shortness of breath which has been increasing when lyingdown. Physical examination found blood pressure 190/136. The patient was diagnosed with G2P1A0H1 gravidpreterm 25-26 weeks, PEB on maintenance dose MgSO4 regimen from outside, suspected nephrotic syndrome,CAP with hypoxemia, pleural effusion, AKI with metabolic acidosis, UTI, hyponatremia, hypoalbuminemia.Discussion: Preeclampsia, eclampsia and HELLP syndrome are serious and life-threatening conditions faced bypregnant women. Early diagnosis and prompt treatment via a multidisciplinary team in the ICU setting canprevent complications and reduce morbidity and mortality. The most common indications for intubation andmechanical ventilation are respiratory failure and hemodynamic instability. The cause of death in this patientwas multiple organ failure which was exacerbated by suspected nephrotic syndrome and suspected SLE.

Congenital Adrenal Hyperplasia In Adolescents Age 18 Years Ibnu Razi Mulya Hasjmy; Dani Kartika Sari; Haviz Yuad
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Congenital adrenal hyperplasia is an autosomal recessive genetic disorder that results in deficiency of enzymes required for steroidogenesis in the cortex of the adrenal glands. The incidence of CAH is rare and it can occur in both males and females. Generally, CYP21 mutations lead to deficiency of the 21-hydroxylase enzyme and failure of adequate cortisol synthesis. Congenital adrenal hyperplasia (CAH) is classified into two types, namely classical and nonclassical types. The patient's clinical manifestation was genital ambiguity in female infants. The aim of this case report is to share our experience of CAH in adolescents in West Sumatera. We report a case of congenital adrenal hyperplasia in an 18 year old girl. The patient was referred to the Urogynecology Obstetrics and Gynecology Department, Dr. M. Djamil Padang with chief complaint of clitoral enlargement since the age of 5 years. On physical examination, vital signs were within normal limits, chest examination revealed Tanner Stage 3 breasts, genital examination revealed an enlarged clitoris with a size of 3x1 cm without the presence of a vaginal canal. Investigations that support the diagnosis are 17-hydroxy progesterone laboratory with a result of 90.2 nmol/L. On ultrasound examination of the abdomen within normal limits with the results of chromosome 46,XX analysis. The patient had not had an adrenal crisis for 18 years. The patient was diagnosed with clitomegaly and the cause of congenital adrenal hyperplasia. The patient was given hydrocortisone therapy at a dose of 20 mg in the morning, followed by a dose of 15 mg at night and planned to undergo clitororeduction surgery by carrying out the perioperative and postoperative hydrocrotisone therapy protocol. The patient's family was given counseling, carried out regular monitoring of the patient and hydrocortisone therapy. Congenital adrenal hyperplasia is a disease caused by genetic disorders that require multidisciplinary management. Enforcement of diagnosis, appropriate management, and counseling are needed to optimize patient growth and development.

A Case Report: Unusual Case of Heterotopic Pregnancy with Chronic Ectopic Pregnancy Putri Embun Pagi; Haviz Yuad
Andalas Obstetrics And Gynecology Journal Vol. 7 No. 2 (2023)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.7.2.453-459.2023

Background :Â Heterotopic pregnancy describes the occurrence of two pregnancies in different implantation sites simultaneously, mostly manifested as intrauterine and ectopic pregnancies (ampullary in 80%). TheÂ Â incidence has been documented due to the increase incidence of pelvic inflammatory diseases.Â Case:Â A 28-years-old primipara woman with suspected chronic ectopic pregnancy, differential diagnosed with ovarian cyst. Previously, the patient had complete abortion becauseÂ abdominal and pelvic pain still present,Â she decided to seek treatment at RSUP dr. Mdjamil, from ultrasound was found suspected chronic ectopic pregnancy differentially diagnosed with ovarian cyst. Laparoscopy had done then,Â Â the intraoperative findings found that there was a chronic ectopic pregnancy in the left ampullary tubal and then left salpingectomy was performed.Conclusion:Â This case is one of the unusual clinical presentations of heterotopic pregnancy. This case highlights the importance of including heterotopic pregnancy in the differential diagnosis especially in patients with persistent abdominal and pelvic pain after complete abortion.Â

MANAGEMENT OF HYPERPROLACTINEMIA CAUSED PITUITARY MICROADENOMA Ibnu Muttaqin; Haviz Yuad
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.502-507.2024

Hyperprolactinemia is an increase in fasting levels of the hormone prolactin above 20 ng/ml in menand above 25 ng/ml in women. Hyperprolactinemia occurs more often in women of reproductive age,with a percentage of 9 â€“ 17%. The etiology of hyperprolactinemia can occur due to abnormal pituitarysecretions, systemic disease, use of drugs, damage to the hypothalamus-pituitary axis. A 33-year oldfemale patient came to the FER Polyclinic at M. Djamil Hospital with complaints of not menstruatingfor the past 2 months. Irregular menstruation since 15 years ago, menstruation 2-3 times in 6 months,irregular cycle for 7-8 days. The patient also complained of a fluid like breast milk coming out of thebreast for 5 years, initially the fluid came out in a trickle and then gradually reduced and now the fluidcomes out occasionally if the breast is squeezed. From the supporting examinations carried out, it wasfound that the prolactin hormone level in this patient was 134.53, and the results of the MRIexamination showed a mass measuring 1.05x1.12x0.5 mm, which was diagnosed as secondaryamenorrhea, hyperprolactinemia, and suspected pituitary microadenoma. The patient will bemonitored for general condition and vital signs, as well as consultations with colleagues involved, suchas consultations to the Internal Medicine section, Endocrinology, Metabolic and Diabetes Subdivision.

THE RELATIONSHIP OF VITAMIN D TOPOLYCYSTIC OVARY SYNDROME (PCOS) TEENAGERS AT KOTO TANGAH PADANG DISTRICT HIGH SCHOOL IN 2022 Hardi Cahyo Utomo; Haviz Yuad; Ida Rahmah Burhan
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.630-646.2024

PCOS is characterized by increased ovarian and adrenal androgen secretion,hyperandrogenic symptoms such as hirsutism, acne and/or alopecia, menstrual irregularities,and polycystic ovaries. The prevalence of PCOS in 2016 was 6âˆ’21% of reproductive ageworldwide. PCOS is the most common female endocrine disorder with a prevalence of around4-6% in women of reproductive age in Indonesia. Vitamin D deficiency can increase PCOSsymptoms. The research design was cross-sectional. The study was conducted at SMA N 7,SMA N 8 and SMA N 13 Padang in Koto Tangah District in May-August 2022. The researchsample was high school students who experienced menstrual cycle disorders and were willingto agree to informed consent for the study with a sample size of 59 respondents. Vitamin Dlevels were examined using the 25-Hydroxyvitamin D ELISA Kit. Data were analyzed by chi-square test. The results showed that 86.4% of respondents experienced vitamin D deficiency.Statistically there was a relationship between PCOS in adolescents accompanied byhyperandrogens and vitamin D levels, there was a relationship between PCOS in adolescentsaccompanied by obesity and vitamin D levels, there was no relationship between PCOS inadolescents accompanied by acanthosis nigrican and vitamin D levels, and there was norelationship between PCOS in adolescents accompanied by hyperandrogens, obesity andacanthosis nigrican with vitamin D levels in SMA Koto Tangah District Padang in 2022. Theconclusion of this study is that there is a relationship between PCOS in adolescentsaccompanied by hyperandrogens and vitamin D levels and there is a relationship betweenPCOS in adolescents accompanied by obesity and vitamin D levels. .

Comparison Of Lactobacillus Plantarum, Lactobacillus Mucosae And Lactobacillus Farciminis Bacteria Between Polycystic Ovary Syndrome And Non Polycystic Ovary Syndrome Students At Medical Faculty Of Andalas University Mentari Faisal Putri; Haviz Yuad; Andani Eka Putra
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 2 (2024)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.2.732-745.2024

Background: Polycystic Ovary Syndrome (PCOS) is a disorder characterized by hyperandrogenism, ovulatory dysfunction, and morphological features of polycystic ovaries. It is associated with insulin resistance and hyperinsulinemia. Gut microbial dysbiosis plays a role in PCOS, which is associated with insulin resistance, hyperandrogenism, chronic inflammation, and metabolic syndrome. PCOS treatment with Probiotics maintains the stability and diversity of the gut microbiome. Objective: To determine the comparison of Lactobacillus plantarum, Lactobacillus mucosae, and Lactobacillus farciminis Bacteria Between Polycystic Ovary Syndrome and Non Polycystic Ovary Syndrome Students at the Medical Faculty of Andalas University. Method: This research was an analytic observational study using a cross-sectional method conducted on female students with Polycystic Ovary Syndrome and Non-Polycystic Ovary Syndrome at the Medical Faculty of Andalas University. Results: Bivariate analysis of microbiota comparison of female students with PCOS and without PCOS, Mann-Whitney Test on L.mucosae (p=0.774), while Independent T-Test analysis on L.farciminis (p=0.006). Conclusion: There is a decrease in microbiota L. Mucosae in female students with PCOS, but there is no significant difference. There is a significant comparison in the number of microbiota L.farciminis in female students with and without PCOS at FK Unand.

Differences in Vitamin D Receptor Levels Between Women With Primary Infertility and Women Without Infertility Shreshta Dewi; Haviz Yuad; Husna Yetti
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 2 (2024)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.2.703-711.2024

Introduction: Many studies have been done on vitamin D, but there is still a lack of data regarding Vitamin D receptor (VDR) level and infertility, whereas VDR has a vital role in the action of vitamin D. Objective: To determine the differences in VDR levels between women with primary infertility and women without fertility problems. Method: This is a case-control study on women with and without fertility problems in Padang City, conducted from March 2023–January 2024. Serum VDR levels (ng/ml) were examined using the ELISA method in the Biomedicine Laboratory at Andalas University. Differences in VDR levels were calculated using the independent T-test. Results: There were 60 subjects divided into 30 subjects with infertility and 30 subjects without fertility problems. Subjects with primary infertility had more 31-35 years and >35 years old patients (54.8% and 66.7%), more overweight and obese BMI patients (50% and 83.3%), and had experienced infertility for 1-4 years (73.3%). The mean VDR levels in infertility subjects were lower than in subjects without fertility problems (1.73±0.92ng/ml and 2.35±1.30ng/ml), where this difference was statistically significant (p=0.036). Conclusion: VDR levels influence the incidence of primary infertility.

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