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All Journal Jurnal Akta Trimedika
Donna Adriani
Fakultas Kedokteran, Universitas Trisakti, Jakarta, Indonesia

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BENEFITS AND RISKS OF ULIPRISTAL ACETATE FOR UTERINE FIBROIDS Triasti Khusfiani; Yudhisman Imran; Irmiya Rachmiyani; Donna Adriani
Jurnal Akta Trimedika Vol. 2 No. 1 (2025): Januari 2025
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/aktatrimedika.v2i1.21724

Abstract

Uterine fibroids (FU) are often experienced by women of reproductive age or in their early menopause with therapy options involving surgical intervention such as hysterectomy. Ulipristal Acetate (UPA) is an oral drug from the selective progesterone receptor modulator (SPRM) class which has been proven to be effective in treating FU symptoms so that patients can maintain their fertility and their uterus. The PEARL I-IV clinical trials (PGL4001/UPA Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata) has proven the effectiveness of this drug in terms of reducing symptoms such as bleeding and pain, reducing fibroid volume, as well as its impact on the patient's quality of life. During ongoing clinical trials, the majority of side effects found were mild-moderate and reversible. In 2020, UPA was discontinued due to reports of the risk of DILI (drug induced liver injury), but after thorough investigation and considering its benefit and risk ratio for patients, UPA can be given again but its indication is limited to intermittent FU therapy with moderate to severe symptoms in women who has not reach menopause or when surgical procedures cannot be performed/have failed. Close monitoring of liver function is of course necessary.
PENGARUH LATIHAN FISIK TERHADAP KEJADIAN INSOMNIA Muhamad Thrisan Caecario; Muhammad Iqbal Aryahikma Trihono; Donna Adriani
Jurnal Akta Trimedika Vol. 2 No. 3 (2025): Juli 2025
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/aktatrimedika.v2i3.22836

Abstract

Sleep is an essential need for humans as sufficient sleep enables individuals to perform their tasks and responsibilities effectively. Sleep disorders can disrupt physical, emotional, cognitive, and social growth. Insomnia is one of the most common sleep disorders, characterized by difficulty initiating or maintaining sleep for more than seven hours. According to the 2018 National Sleep Foundation data, the global prevalence of insomnia reached 67% among 1,507 people in Southeast Asia. In Indonesia, the prevalence of insomnia was 10% among 238 million people, with approximately 23 million individuals experiencing it. This disorder is more common in older adults, women, and those with mental health issues. People with insomnia often feel sleepy during the day, have trouble concentrating, and experience depression. Factors influencing insomnia include age, gender, family history, work environment, smoking behavior, and both mental and physical health. Exercise, including aerobic and anaerobic exercise, can affect insomnia occurrence. Structured exercise could have either positive or negative impacts on sleep quality, depending on its intensity and timing. The author hopes this study will provide further insights into the influence of physical exercise on insomnia. Conclusion: exercise performed in the morning has a positive impact on insomnia. However, if it is done at high intensity in the evening, it could increase the risk of insomnia if not properly timed. High-intensity exercise in the evening is recommended to finish 2 to 4 hours before bedtime.
Co-Authors Irmiya Rachmiyani Muhamad Thrisan Caecario Muhammad Iqbal Aryahikma Trihono Triasti Khusfiani Yudhisman Imran