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Zara Aulia
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Materials Science & Nanotechnology

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Penentuan Kadar Astaxanthin, Uji Antiinflamasi Dan Sitotoksik Terhadap Sel Kanker Payudara Ekstrak Aseton Spirulina Platensis Armaini; Syafrizayanti; Zara Aulia
Jurnal Kimia Unand Vol. 11 No. 1 (2022): May 2022
Publisher : Departemen Kimia Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jku.11.1.25-32.2022

Abstract

Spirulina platensis is a microalgae widely used in the health sector due to its micronutrients, biopigment such as astaxanthin. Astaxanthin is carotenoid belonging to strong antioxidant, which has anti-inflammatory and cytotoxic effects on MCF-7 breast cancer cells. This study aims to determine astaxanthin contents, to investigate the anti-inflammatory activity and cytotoxic potential of breast cancer cells MCF-7 treated with acetone extract from Spirulina platensis. Extraction is done by maceration method. Astaxanthin contents were determined using UV-Vis spectrophotometer set to 479 nm. The anti-inflammatory assays were performed using inhibition of protein denaturation method and cytotoxic assays were performed using the MTT method. From results of study, the extract contained 6,3008 mg/L astaxanthin. The IC50 values for anti-inflammatory and cytotoxic tests ​​were 363,399 mg/L and 66,68 mg/L, respectively. According to the result of the tests, acetone extract from Spirulina platensis showed anti-inflammatory activity and moderate cytotoxic activity against MCF-7 breast cancer cells.
Co-Authors Armaini Syafrizayanti