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All Journal Jurnal Farmasi dan Sains Indonesia (JFSI) Medical Sains : Jurnal Ilmiah Kefarmasian
Urva Fresiva
Universitas Wahid Hasyim
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience

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REVIEW: ANTIBACTERIAL, ANTIFUNGAL AND WOUND HEALING ACTIVITY OF NANOEMULGEL FORMULATIONS AND PHYSICAL CHARACTERISTICS Rodhia Ulfa; Wildan Khairi Muhtadi; Urva Fresiva; Amraini Amelia
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1193

Abstract

Nanoemulgel is an emulsion preparation with a droplet size of 1–100 nm suspended in a hydrogel. This review delves into the research on the impact of incorporating excipient components in nanoemulgel formulations to create products with specific physical attributes for different active ingredients with antifungal, antibacterial, and wound-healing properties. The research approach involves comparing articles on nanoemulgel preparation formulations with different combinations of active ingredients and excipients, as well as their pharmacological effects. Enhancing the level of active ingredients and altering the excipients can boost the effectiveness of nanoemulgel formulations in combating fungi, bacteria, and promoting wound healing. The review includes articles published within the past decade. Keywords: Nanoemulgel, Pharmacological activity, Physical characteristics, Review
Formulasi Self Nanoemulsifying drug delivery system Enzim Bromelain buah Nanas Ananas comosus Urva Fresiva; M Fatchur Rochman; Flomaria Tianingsih; Resty Pratiwi; Amalia Anugrahi
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p9-14

Abstract

The pineapple fruit's bromelain enzyme exhibits pharmacological activity as an antibacterial and anti-inflammatory. The bromelain enzyme was formulated as tablets and powders in earlier research, although this still had the disadvantage of having a higher formulation resistance. Formulating and characterizing SNEDDS of the bromelain enzyme with oil phase, surfactant, and co-surfactant—specifically, clove oil, propylene glycol, and PEG 400—is the goal of this study. The process for creating SNEDDS bromelain enzyme involves combining the carrier in different quantities, adding the enzyme, and evaluating it based on factors including homogeneity, adhesion, spreadability, clarity, and organoleptic characteristics. The active ingredient in the SNEDDS formulation that was obtained was 360 mg of bromelain enzyme per milliliter of SNEDDS. With a 2:5:3 concentration ratio of clove oil, PG, and PEG 400, the transmittance percentage of SNEDDS is 98.54 ± 0.02%, the spreadability is 2.2 cm, the adhesion is 116 seconds, and the pH is 6.48. In comparison to other carrier concentrations, SNEDDS bromelain enzyme SNEDDS with a concentration ratio of 2:5:3 for clove oil, PG, and PEG 400 yields superior characteristic results.
Co-Authors Amalia Anugrahi Amraini Amelia Flomaria Tianingsih M Fatchur Rochman Muhtadi, Wildan Khairi Resty Pratiwi Rodhia Ulfa