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All Journal Padjadjaran Journal of Dentistry B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah MDJ (Makassar Dental Journal) Denta: Jurnal Kedokteran Gigi
Pascawinata, Andries
Department Of Oral And Maxillofacial Surgery Faculty Of Dentistry, Baiturrahmah University Padang, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Antibacterial Activity of Low-Concentration Ethyl Acetate Fraction of Tridax procumbens Against Streptococcus mutans Widyawati, Widyawati; Rahmania, Anggun; Pascawinata, Andries
Denta Journal Kedokteran Gigi Vol 20 No 2 (2026): August
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v20i2.3

Abstract

Background: Streptococcus mutans is a major cariogenic bacterium involved in dental plaque formation and enamel demineralization. Although chlorhexidine is widely used as an antibacterial agent, its long-term use may cause adverse effects, prompting the search for natural alternatives. Tridax procumbens L. (T. procumbens) contains bioactive compounds with potential antibacterial properties. Objective: To evaluate the antibacterial activity of the ethyl acetate fraction of T. procumbens against Streptococcus mutans. Materials and Methods: An in vitro experimental study with a post-test-only control group design was conducted using six groups: ethyl acetate fractions of T. procumbens at concentrations of 2%, 4%, 6%, and 8%, a 0.2% chlorhexidine positive control, and a negative control. Each group consisted of four replicates. Antibacterial activity was evaluated using the agar disk diffusion method by measuring inhibition zone diameters. Data were analyzed using the Kruskal–Wallis test, followed by the Mann–Whitney test. Results: All tested concentrations exhibited antibacterial activity against S. mutans. The 8% ethyl acetate fraction produced the largest mean inhibition zone among the tested concentrations and showed an inhibitory effect comparable to that of 0.2% chlorhexidine. Statistical analysis revealed significant differences between treatment groups (p < 0.05). However, no significant differences were observed among the 2%, 4%, 6%, and 8% concentrations. Conclusion: The ethyl acetate fraction of T. procumbens exhibited antibacterial activity against Streptococcus mutans. The 8% concentration produced the greatest inhibitory effect, although increasing the concentration from 2% to 8% did not significantly enhance antibacterial activity. These findings indicate its potential as a natural antibacterial agent against S. mutans.
Co-Authors Al Majiid, Muhammad Shalahuddin Andriansyah Andriansyah Bambang Dwirahardjo Bariyah, Naim Citra Lestari Efa Ismardianita Efa Ismardianita, Efa Fadil Muhammad Pashya Firdaus Firdaus Masra Roesnoer Masykur Rahmat Prihartiningsih Prihartiningsih Rahmania, Anggun Refo Bismanevi Sarah Putri Utami Velanita, Siti Wenny Rosalina Widyawati Widyawati