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All Journal Jurnal Florea Jurnal Penelitian Pendidikan IPA (JPPIPA) COMPTON: Jurnal Ilmiah Pendidikan Fisika
Harlita
Universitas Sebelas Maret
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Materials Science & Nanotechnology Physics

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Molecular Docking of Gamma Amino Butyric Acid GABA on Rattus Norvegicus B-receptor as Antidiabetic Meti Indrowati; Harlita; Umi Fatmawati; Joko Ariyanto; Estu Retnaningtyas
Jurnal Penelitian Pendidikan IPA Vol 10 No 7 (2024): July
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i7.8044

Abstract

Earlier research reported that GABA had a correlation with diabetes in processes of glucose homeostasis. This study aims to identify the validity of B-receptor Rattus norvegicus as GABA protein target, modeling the structure and knowing the binding affinity between GABA and B-receptor Rattus norvegicus through molecular docking.   The research was carried out using in-silico method.  The interaction of GABA with the target protein was determined using SuperPred, followed by modeling the protein target using SwissadMe. Ramachandran Plot and Errat Procheck are used to determine the validity of the protein target. Molecular docking was determined using Pyrx and PyMol. The results showed that GABA binding to the B- receptor Rattus norvegicus has biological activity as glucose oxidase inhibitor and antidiabetic.  The conclusion are: B-receptor Rattus norvegicus is a valid protein target for binding to GABA; there are four 3-dimensional models of B-receptor Rattus norvegicus and the best model has 98.43% sequence identity; the binding affinity of GABA (ligand) on B-receptor Rattus norvegicus from the best model is -3.4 kcal/mol energy, 1.773 RMSD lower bound, and 1.81 RMSD upper bound. It is suggested that this research might be used as an empirical basis to further investigate GABA as antidiabetic.
Data Literacy in STEM-Based Biology Education: A Systematic Review of Trends and Empirical Studies Intan Rahma Sari; Murni Ramli; Harlita
Florea : Jurnal Biologi dan Pembelajarannya Vol. 13 No. 2 (2026)
Publisher : UNIVERSITAS PGRI MADIUN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25273/florea.v13i2.24913

Abstract

Data literacy is a critical competency in 21st-century STEM-based biology education, enabling students to analyze, interpret, and use data for evidence-based decision-making. However, research on this topic remains fragmented and lacks comprehensive synthesis. This study aimed to examine research trends, distribution patterns, and future directions of data literacy in STEM-based biology education. A Systematic Literature Review (SLR) following the PRISMA 2020 framework was conducted using 52 empirical articles indexed in Scopus from 2015 to 2026. The data were analyzed through thematic and bibliometric approaches using VOSviewer and Biblioshiny (Bibliometrix-R). The results showed a substantial increase in publications between 2022 and 2025. Nevertheless, research distribution remains uneven, characterized by the dominance of developed countries, limited international collaboration, and dispersed contributions across authors, institutions, and journals. Bibliometric findings identified data literacy as the central research theme, closely associated with STEM education and increasingly connected to data science. Thematic evolution revealed a shift from foundational conceptual discussions toward technology-oriented and data-driven approaches. These findings highlight the growing importance of data literacy in biology education and emphasize the need for integrated theoretical frameworks, interdisciplinary collaboration, and the adoption of innovative technologies to support future educational practices and research.
Analyzing critical thinking enhancement and moment of inertia understanding through inquiry based virtual labs Sony Yunior Erlangga; Sarwanto; Harlita; Isnanik Juni Fitriyah; Resti Yektyastuti; Krida Singgih Kuncoro; Betty Kusumaningrum
COMPTON: Jurnal Ilmiah Pendidikan Fisika Vol 11 No 2 (2025): Compton: Jurnal Ilmiah Pendidikan Fisika
Publisher : Prodi Pendidikan Fisika Universitas Sarjanawiyata Tamansiswa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30738/cjipf.v11i2.19628

Abstract

This study examines the effectiveness of inquiry-based virtual laboratory modules in improving civil engineering students' conceptual understanding of moment of inertia, with critical thinking skills as a moderating factor. Using a quasi-experimental 2x2 factorial design, 60 students were divided into experimental and control groups. The experimental group engaged with virtual lab modules featuring interactive simulations and case-based learning, while the control group received conventional lecture-based instruction. Results indicated significantly higher learning outcomes in the experimental group (mean score = 58.9) compared to the control group (46.5), with critical thinking skills further amplifying this effect. ANOVA analysis confirmed the significant impact of the intervention (F = 21.83, p < 0.001). The study highlights the importance of integrating technology with pedagogical strategies that foster critical analysis and self-directed exploration. These findings contribute to engineering education by demonstrating how virtual labs, when combined with inquiry-based learning, can bridge the gap between theoretical knowledge and practical application while accommodating diverse learning needs. Recommendations include curriculum integration of such modules and professional development for educators in implementing technology-enhanced, inquiry driven approaches.
Co-Authors Betty Kusumaningrum Estu Retnaningtyas Intan Rahma Sari Isnanik Juni Fitriyah Joko Ariyanto Krida Singgih Kuncoro Meti Indrowati Murni Ramli Resti Yektyastuti Sarwanto Sony Yunior Erlangga Umi Fatmawati