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All Journal JURNAL PESISIR DAN LAUT TROPIS
Inneke FM Rumengan
FPIK UNSRAT
Earth & Planetary Sciences

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PENAMBATAN MOLEKUL GLUTATION FAUNA LAUT TERHADAP RESEPTOR DARI BEBERAPA PENYAKIT VIRUS Q Xaxa Alvin Kai; Inneke FM Rumengan; Rosita AJ Lintang; Stenly Wullur; Deiske A Sumilat; Henneke Pangkey; Hein A Luntungan
JURNAL PESISIR DAN LAUT TROPIS Vol. 9 No. 2 (2021): JURNAL PESISIR DAN LAUT TROPIS
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35800/jplt.9.2.2021.34853

Abstract

Glutathion is a tripeptides produced by almost all living creatures, including marine fauna such as rotifers and shrimps. Judging from the important molecular role of glutathion in living cell,  the ability of glutathion as antiviral compound, has been assed by application of the AutodockTools to predict the ability of glutathion as ligand to bind receptors of several viral diseases such as  covid-19, malaria, and hepatitis B. Docking results of glutathion toward target receptor were shown by the parameter, Gibbs energy value, and supported by other data such as the amount of hidrogen bond, amino acid residues, and bond distance. Evidently, the glutathion could bind to  each receptor of covid-19, malaria and hepatitis B, with values of  Gibbs energy (∆G), -7,9, 7,1 and -7,1 kcal/mol, respectively. This proves that glutathion has ability to bind covid-19 receptor, even stronger than its ability to bind receptors of other viral diseases, and to the remdesevir. Between glutathion and covid-19 receptor, there were 11 hidrogen bonds, with distance ranged from 2,76 to 3,25 Å. These were stronger than those between glutathion and receptors of malaria and hepatitis B, only  8 and 4 Å hidrogen bonds, respectively.  To develop glutathion as antiviral drug, it is necessary to carry out in vitro and in vivo analyses, prior to clinical test. Therefore, it requires to explore the marine fauna species that produce glutathion and their cultivation.Keywords: molecular docking, glutathion, marine fauna, autodock vina, viral diseases, binding affinity
Uji Potensi Ekstrak Kasar Teripang Laut Holothuria atra Untuk Anti Kanker Dengan Menggunakan Metode Brine Shirmp Lethality Test Yunita Baramuli; Nickson Kawung; James JH Paulus; Inneke FM Rumengan; Billy Th Wagey; Fransin Manginsela
JURNAL PESISIR DAN LAUT TROPIS Vol. 9 No. 3 (2021): JURNAL PESISIR DAN LAUT TROPIS
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35800/jplt.9.3.2021.36520

Abstract

The aim of this research is to test the potency of Sea cucumber crude extract Holothuria atra using the shrimp larvae Artemia salina Leach. The sample were take from waters of tateli at Minahasa District. Sample preparation and the potential test were done at biology moleculer and marien pharmacy laboratorium of Faculty of Fhiseries and Marine Science Sam Ratulangi University. The sample macerated once with ethanol for 24 hours. Extract of the sample were conentrated using rotary evaporator. Using the  Brine Shrimp Lethality Test (BSLT) method  with shrimp larvae Artemia salina, Leach. As the sample dry weight  of the sample is 420 g after macerated with ethanol then decreased to 18 g after evaporated. Probit analysis of larva mortalityt data as the indicator of anti-cancer potential shown the value LC5030.01 mg/l. Bioactive compounds of sea cucumber H. arta has potency to be develop as anti-cancer material. Keywords: Anti cancer, Sea cucumber, Holothuria atra, Artemia salina leach   
Co-Authors Billy Th Wagey Deiske A Sumilat Fransin Manginsela Hein A Luntungan Henneke Pangkey James JH Paulus Nickson Kawung Q Xaxa Alvin Kai Rosita AJ Lintang Stenly Wullur Yunita Baramuli