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All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences Journal of Environmental Science and Sustainable Development
Azra, Mohamad Nor
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Earth & Planetary Sciences Environmental Science

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A PECULIAR NATURAL WONDERLAND OF SOUTH CHINA SEA: A BIRD’S EYE VIEW Azra, Mohamad Nor; Noor, Mohd Iqbal Mohd; Seman, Juneta-nor Abu; Seong Wei, Lee, Dr
Journal of Environmental Science and Sustainable Development Vol. 6, No. 2
Publisher : UI Scholars Hub

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Abstract

The South China Sea research agenda has increased over the years. However, no scientometric studies have been performed on this topic, which has helped analyze the research on the South China Sea throughout many years. Thus, this study aimed to investigate the global findings of previous research on the South China Sea, development trends, and trending issues surrounding the sea. Literature was extracted from the Web of Science Core Collection (WOSCC) database, and the CiteSpace software was used to visualize the data analyzed. The survey included 12,755 articles. Overall, the number of publications increased annually. Acta Oceanologica Sinica and the Chinese Academy of Science are the journals and affiliations with the most relevant studies, respectively. China is at the forefront of research regarding the South China Sea, with more than four times as many articles as the USA. The most common keywords were variability, ocean, model, evolution, circulation, and water. The most recent keywords were East Asian monsoon and metabolite, indicating a shift in research priorities. This study is the first to perform a scientometric analysis of the South China Sea. This study is expected to assist researchers, academics, and investigators in exploring potential research directions in the South China Sea. The study also hopes to contribute towards Sustainable Development Goals 11 and 14, Sustainable Cities and Communities, and Life Below Water.
Exploring the Anti-Menopausal Potential of Rhizophora mucronata Lam. Ethanol Extract: A Comprehensive Study on Estrogen Receptor β Agonist Activity Ernawati, Ernawati; Adam, Moh. Awaludin; Widiastuti, Irawati Mei; Insivitawati, Era; Nikmatullah, Muhammad; Riyadi, Putut Har; Azra, Mohamad Nor
ILMU KELAUTAN: Indonesian Journal of Marine Sciences Vol 29, No 3 (2024): Ilmu Kelautan
Publisher : Marine Science Department Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/ik.ijms.29.3.414-424

Abstract

Mangrove is a tropical forest that stores millions of benefits ecologically, biologically, and economically. Rhizophora fruit extract contained bioactive compounds components derived from natural ingredients and scientifically proven to have positive effects on health, among others, to prevent cancer, etc. This study aimed to investigate the potential of R. mucronata ethanol extract as an estrogen receptor β agonist for anti-menopausal purposes. Using a Completely Randomized Design (CRD), 25 mice were divided into five groups: a normal control group (NK), an ovariectomy control group (Ovx), and three ovariectomized groups (Ovx D1, D2, and D3) receiving different doses of the extract (200, 400, and 800 mg.kg-1 BW, respectively). The extract was administered orally, and various measurements were taken, including flavonoid content, using densitometry thin layer chromatography (TLC) and FTIR for functional group characterization. The study found a high rutin content (13.29%) in the fruit. Twelve compounds with potential estrogenic activity were identified, which were analyzed using SwissAdme software. Estradiol levels in serum increased with higher doses of the extract over four weeks. In silico and in vivo analysis showed 5 (five) selected compounds from the ethanol and ethyl acetate fractions with highest (most negative) to lowest binding affinity as candidates for anti-menopausal drugs. The administration of R. mucronata Lam. fruit extract in Ovx D1, Ovx D2 and Ovx D3 gave significantly different effects to each other on rat blood serum estradiol hormone levels. In this study, the dose 400 mg.L-1 BW rat gave P>5 increasing blood serum estradiol levels of ovariectomized rats.
Co-Authors Ernawati Ernawati Insivitawati, Era Irawati Mei Widiastuti Moh. Awaludin Adam Nikmatullah, Muhammad Noor, Mohd Iqbal Mohd Putut Har Riyadi Seman, Juneta-nor Abu Seong Wei, Lee, Dr