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All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences International Journal of Kita Kreatif
Nikmatullah, Muhammad
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Earth & Planetary Sciences Economics, Econometrics & Finance Social Sciences

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Exploring the Anti-Menopausal Potential of Rhizophora mucronata Lam. Ethanol Extract: A Comprehensive Study on Estrogen Receptor β Agonist Activity Ernawati, Ernawati; Adam, Moh. Awaludin; Widiastuti, Irawati Mei; Insivitawati, Era; Nikmatullah, Muhammad; Riyadi, Putut Har; Azra, Mohamad Nor
ILMU KELAUTAN: Indonesian Journal of Marine Sciences Vol 29, No 3 (2024): Ilmu Kelautan
Publisher : Marine Science Department Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/ik.ijms.29.3.414-424

Abstract

Mangrove is a tropical forest that stores millions of benefits ecologically, biologically, and economically. Rhizophora fruit extract contained bioactive compounds components derived from natural ingredients and scientifically proven to have positive effects on health, among others, to prevent cancer, etc. This study aimed to investigate the potential of R. mucronata ethanol extract as an estrogen receptor β agonist for anti-menopausal purposes. Using a Completely Randomized Design (CRD), 25 mice were divided into five groups: a normal control group (NK), an ovariectomy control group (Ovx), and three ovariectomized groups (Ovx D1, D2, and D3) receiving different doses of the extract (200, 400, and 800 mg.kg-1 BW, respectively). The extract was administered orally, and various measurements were taken, including flavonoid content, using densitometry thin layer chromatography (TLC) and FTIR for functional group characterization. The study found a high rutin content (13.29%) in the fruit. Twelve compounds with potential estrogenic activity were identified, which were analyzed using SwissAdme software. Estradiol levels in serum increased with higher doses of the extract over four weeks. In silico and in vivo analysis showed 5 (five) selected compounds from the ethanol and ethyl acetate fractions with highest (most negative) to lowest binding affinity as candidates for anti-menopausal drugs. The administration of R. mucronata Lam. fruit extract in Ovx D1, Ovx D2 and Ovx D3 gave significantly different effects to each other on rat blood serum estradiol hormone levels. In this study, the dose 400 mg.L-1 BW rat gave P>5 increasing blood serum estradiol levels of ovariectomized rats.
THE INFLUENCE OF SERVICE QUALITY AND PRICES IS MEDIATED BY CONSUMER SATISFACTION ON REPEAT PURCHASE AT HALAL RESTAURANTS IN THE CITY OF BANDA ACEH Nikmatullah, Muhammad; Kesuma, Teuku Meldi
International Journal of Kita Kreatif Vol 1, No 1 (2024): International Journals Kita Kreatif Vol.1 No.1 Februari 2024
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/ijkk.v1i1.37612

Abstract

This research aims to analyze the influence of service quality and price on repeat purchases at halal restaurants in Banda Aceh with consumer satisfaction as a mediating variable. Samples used. The objects of this research are the people of Banda Aceh who have visited halal restaurants. This research uses a quantitative approach, with a non-probability sampling method using purposive sampling technique with a sample size of 100 respondents. The data used in this research are primary data and secondary data. Primary data was obtained from distributing questionnaires to respondents and secondary data from literature study. The analysis used is descriptive analysis. Based on the results of the research analysis, it was found that service quality had a positive and significant effect on repeat purchases. Consumer Satisfaction partially mediates the influence of Service Quality and Price on Repeat Purchases.
Co-Authors Azra, Mohamad Nor Ernawati Ernawati Insivitawati, Era Irawati Mei Widiastuti Moh. Awaludin Adam Putut Har Riyadi Teuku Meldi Kesuma, Teuku Meldi