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All Journal International Journal of Electrical and Computer Engineering ILMU KELAUTAN: Indonesian Journal of Marine Sciences Saintek Perikanan : Indonesian Journal of Fisheries Science and Technology DedikasiMU: Journal of Community Service Jurnal Perikanan
Insivitawati, Era
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Religion Agriculture, Biological Sciences & Forestry Humanities Computer Science & IT Earth & Planetary Sciences Education Electrical & Electronics Engineering Environmental Science Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Social Sciences

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Exploring the Anti-Menopausal Potential of Rhizophora mucronata Lam. Ethanol Extract: A Comprehensive Study on Estrogen Receptor β Agonist Activity Ernawati, Ernawati; Adam, Moh. Awaludin; Widiastuti, Irawati Mei; Insivitawati, Era; Nikmatullah, Muhammad; Riyadi, Putut Har; Azra, Mohamad Nor
ILMU KELAUTAN: Indonesian Journal of Marine Sciences Vol 29, No 3 (2024): Ilmu Kelautan
Publisher : Marine Science Department Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/ik.ijms.29.3.414-424

Abstract

Mangrove is a tropical forest that stores millions of benefits ecologically, biologically, and economically. Rhizophora fruit extract contained bioactive compounds components derived from natural ingredients and scientifically proven to have positive effects on health, among others, to prevent cancer, etc. This study aimed to investigate the potential of R. mucronata ethanol extract as an estrogen receptor β agonist for anti-menopausal purposes. Using a Completely Randomized Design (CRD), 25 mice were divided into five groups: a normal control group (NK), an ovariectomy control group (Ovx), and three ovariectomized groups (Ovx D1, D2, and D3) receiving different doses of the extract (200, 400, and 800 mg.kg-1 BW, respectively). The extract was administered orally, and various measurements were taken, including flavonoid content, using densitometry thin layer chromatography (TLC) and FTIR for functional group characterization. The study found a high rutin content (13.29%) in the fruit. Twelve compounds with potential estrogenic activity were identified, which were analyzed using SwissAdme software. Estradiol levels in serum increased with higher doses of the extract over four weeks. In silico and in vivo analysis showed 5 (five) selected compounds from the ethanol and ethyl acetate fractions with highest (most negative) to lowest binding affinity as candidates for anti-menopausal drugs. The administration of R. mucronata Lam. fruit extract in Ovx D1, Ovx D2 and Ovx D3 gave significantly different effects to each other on rat blood serum estradiol hormone levels. In this study, the dose 400 mg.L-1 BW rat gave P>5 increasing blood serum estradiol levels of ovariectomized rats.
Algae content estimation utilizing optical density and image processing method Kamaluddin, Muhammad Wafiq; Gunawan, Agus Indra; Setiawardhana, Setiawardhana; Dewantara, Bima Sena Bayu; Insivitawati, Era; Asmarany, Anja; Pratama, Ariesa Editya
International Journal of Electrical and Computer Engineering (IJECE) Vol 14, No 6: December 2024
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijece.v14i6.pp6248-6257

Abstract

One of the factors that influence shrimp cultivation is the presence of algae. Precise knowing algae content in the pond is essential for effective management. Most research in the field of algae species carried out by researchers were observing Chlorella Sp. more than the other algae species, with a particular emphasis on substance concentrations. This study proposed non-invasive techniques for quantifying algae abundance, utilizing optical density (OD) and image processing (IP) methods. Three different algae species are frequently found in Indonesia i.e., Chlorella Sp., Thalassiosira Sp., and Skeletonema Sp. are used as sample. Those samples are cultured and prepared in a certain volume with a certain quantity. For experimental and observation purposes, those samples are then diluted into water based on percentage value. The experimental results provided RGB values, which were then used to establish polynomial equations. To verify these equations, two approaches were employed: synthetic image analysis and evaluation using additional data. The mean average error (MAE) was found to be 3.467 for IP method and 3.513 for OD method. It shows that IP method give better result compared to OD method in this study. However, it is very possible that the two methods will complement each other.
HISTOPATHOLOGIC FEATURES OF HEPATOPANCREAS INFECTED WITH Vibrio parahaemolyticus IN VANNAMEI SHRIMP (Litopenaeus vannamei) Wijaya, Avira Salsabila; Insivitawati, Era; Sugianti, Budi
Jurnal Perikanan Unram Vol 15 No 1 (2025): JURNAL PERIKANAN
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jp.v15i1.1434

Abstract

Shrimp farming faces a major problem, which is the disease caused by Vibrio parahaemolyticus infection, leading to vibriosis and damage to the shrimp's hepatopancreas. This study aims to analyze the pathological changes that occur in the tissues and organs of vannamei shrimp due to Vibrio parahaemolyticus infection using histopathological testing methods. The research findings show that this bacterial infection causes damage to the hepatopancreas, including hemocyte infiltration, melanization, sloughing, necrosis, and bacterial colonization. This damage is caused by toxins produced by Vibrio parahaemolyticus, leading to the degeneration of cells and tissues. This study provides important information that can be used to develop prevention and treatment strategies for diseases in vannamei shrimp farming, as well as enhance understanding of the impact of bacterial infection on the hepatopancreas organ of shrimp.
PELATIHAN DAN PENDAMPINGAN APLIKASI PENGKAYAAN BIOENKAPSULASI NAUPLI ARTEMIA DENGAN KOMBINASI EKSTRAK KETAPANG JAHE KENCUR KUNYIT DI HATCHERY DESA PACIRAN, KABUPATEN LAMONGAN Insivitawati, Era; Wahidi, Budi Rianto; Jayanti, Shara; Sugianti, Budi; Asmarani, Anja
DedikasiMU : Journal of Community Service Vol 7 No 1 (2025): Maret
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/dedikasimu.v7i1.8744

Abstract

Budidaya udang vannamei skala rumah tangga di Desa Paciran, Kecamatan Paciran, Kabupaten Lamongan, seringkali menghadapi masalah kematian pada benih atau larva. Pengabdian kepada masyarakat ini bertujuan untuk membantu mengatasi permasalahan pembudidaya dalam meningkatkan kelangsungan hidup larva udang melalui pemberian pakan fungsional berupa bioenkapsulasi naupli artemia yang diperkaya dengan ekstrak ketapang, jahe, kencur, dan kunyit sebagai imunostimulan. Metode yang digunakan meliputi pelatihan dan pendampingan kepada pembudidaya tentang pembuatan imunostimulan dari ekstrak ketapang, jahe, kencur, dan kunyit dan bioenkapsulasi. Hasil yang diperoleh menunjukkan bahwa bioenkapsulasi naupli artemia dengan ekstrak ketapang, jahe, kencur, dan kunyit dapat menjadi alternatif yang efektif untuk meningkatkan kualitas benih udang dan mengurangi tingkat kematian. Penerapan teknologi ini diharapkan dapat meningkatkan produksi dan produktivitas budidaya udang vannamei skala rumah tangga.
EFEKTIVITAS DAUN KETAPANG (Terminalia catappa) DAN BAWANG PUTIH (Allium sativum) SEBAGAI IMUNOSTIMULAN HERBAL PADA BUDIDAYA IKAN NILA (Oreochromis niloticus) Insivitawati, Era; Wahidi, Budi Rianto; Asmarany, Anja; Hakimah, Nisa; Jayanti, Shara; Setyatuti, Tri Ari; Suseno, Dewi Nurmalita; Sugianti, Budi
Saintek Perikanan : Indonesian Journal of Fisheries Science and Technology Vol 21, No 2 (2025): SAINTEK PERIKANAN
Publisher : Fakultas Perikanan dan Ilmu Kelautan, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/ijfst.21.2.138-144

Abstract

Budidaya ikan nila (Oreochromis niloticus) berpotensi besar, namun rentan terinfeksi bakteri dan memerlukan solusi alternatif pengganti antibiotik sintetis. Daun ketapang (Terminalia catappa) dan bawang putih (Allium sativum) bersifat antimikroba dan imunostimulan, namun efektivitas dan formulasi optimal masih memerlukan penelitian lebih lanjut. Penelitian ini bertujuan mengevaluasi efektivitas kombinasi daun ketapang dan bawang putih untuk mencari alternatif pengendalian bakteri yang lebih aman, mengingat penggunaan obat berlebihan dapat memicu resistensi. Daun ketapang dan bawang putih dipilih sebagai imunostimulan herbal yang potensial menekan bakteri Aeromonas tanpa dampak negatif bagi lingkungan. Metode yang digunakan adalah eksperimen Rancangan Acak Lengkap (RAL) dengan 4 perlakuan dan 3 ulangan yaitu  Perlakuan Kontrol tanpa pemberian ekstrak daun ketapang dan bawang putih, Perlakuan A (komposisi 75 % daun ketapang dan 25% bawang putih), Perlakuan B (komposisi 50 % daun ketapang dan 50% bawang putih), dan Perlakuan C (komposisi 25 % daun ketapang dan 75% bawang putih). Pengujian mencakup uji fitokimia, zona hambat, DPPH (2,2-Diphenyl-1-picrylhydrazyl), analisis kualitas air dan pertumbuhan ikan dengan uji statistik. Hasil menunjukkan kombinasi 50% daun ketapang dan 50% bawang putih (Perlakuan B) merupakan yang terbaik dan berpotensi meningkatkan daya tahan tubuh ikan dengan kadar alkaloid tertinggi sebesar 37,91% (b/b) dengan persentase Relative Percent Difference (RPD) 1,5%, IC50 Uji DPPH 3,79 mg/ml, menghambat pertumbuhan bakteri yang ditunjukkan dengan hasil zona hambat terbesar, pertumbuhan berat terbaik dengan ABW mencapai 17,60 ± 6,84 gram/ekor dan ADG 1,53 g/minggu. Penelitian ini mengindikasikan bahwa kombinasi daun ketapang dan bawang putih dapat menjadi imunostimulan alami yang ramah lingkungan dalam budidaya ikan nila.
Co-Authors Asmarani, Anja Asmarany, Anja Azra, Mohamad Nor Bima Sena Bayu Dewantara Budi Rianto Wahidi Ernawati Ernawati Gunawan, Agus Indra Irawati Mei Widiastuti Jayanti, Shara Kamaluddin, Muhammad Wafiq Moh. Awaludin Adam Nikmatullah, Muhammad Nisa Hakimah Pratama, Ariesa Editya Putut Har Riyadi Setiawardhana, Setiawardhana Setyatuti, Tri Ari Sugianti, Budi Suseno, Dewi Nurmalita Wijaya, Avira Salsabila