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All Journal Jurnal Farmasi Udayana Indonesian Journal of Cancer Chemoprevention
Kusuma, I Made Gede Ari
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Analisis Kadar Glukomanan dan Evaluasi Biopolimer Edible Film Umbi Porang Sebagai Pengemasan Pangan Fungsional Putra, I Gusti Ngurah Trisna Meyana; Kusuma, I Made Gede Ari; Kurniadinata, I Putu Bagus; Wulandari, Ni Made Widya; Dewi, Ni Komang Gita Listyari; Astuti, Ni Made Widi
Jurnal Farmasi Udayana Vol. 13, No. 1, Tahun 2024
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

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Abstract

Kemasan mampu melindungi produk dari kontaminasi. Namun, disisi lain kemasan juga dapat sebagai sumber utama timbulnya limbah. Edible film adalah suatu bahan yang dapat diaplikasikan dalam pelapis dan pembungkus hidangan yang bisa dikonsumsi secara langsung bersama bahan makanan tersebut serta dapat menjaga sterilitas makanan dan mencegah hilangnya komponen gizi makanan. Produksi edible film dari glukomanan umbi porang ini melalui serangkaian tahapan produksi. Diawali dengan pembuatan tepung porang, penentuan kadar glukomanan, penentuan kadar kalsium oksalat, identifikasi dengan FTIR, pembuatan edible film, serta uji evaluasi atau karakterisasi edible film seperti uji organoleptis, ketebalan, kadar air, laju transmisi uap air, daya menahan air, dan daya menahan minyak. Kadar glukomanan dan kalsium oksalat yang didapatkan dari riset ini adalah sebesar 87,7% dan 59,1829 mg/100 g. Identifikasi dengan FTIR ditemukan adanya gugus -OH, -CH2, -CO dan -CH yang sesuai dengan pustaka. Hasil uji ketebalan edible film adalah 0,123 mm; 0,143 mm; 0,156 mm. Hasil uji kadar air adalah 6,331%; 6,728%; 7,6%. Hasil uji laju transmisi uap air adalah 10,147 g/jam.m2 ; 13,345 g/jam.m2 ; dan 24,108 g/jam.m2 . Hasil uji daya menahan air adalah 7,209 g/g; 7,266 g/g; dan 7,389 g/g. Hasil uji daya menahan minyak adalah 2,698 g/g; 2,495 g/g; dan 2,483 g/g.
Unravelling Potential Mechanisms of Piper retrofractum Vahl. Bioactive Compounds as Cervical Cancer Chemopreventive Agent by Bioinformatic Approach Mahindra, I Kadek Sindhu Satya; Kusuma, I Made Gede Ari; Sari, Wayan Dianda; Diantari, Desak Made Dewi; Lestari, Priyanka; Santika, I Wayan Martadi
Indonesian Journal of Cancer Chemoprevention Vol 15, No 1 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss1pp50-62

Abstract

Cervical cancer is the leading cause of cancer death after breast cancer. HPV infection is the main cause of cervical cancer which will cause overexpression of E6 oncoprotein. E6 oncogene can cause cancer cells to continue to proliferate. Long pepper fruit (Piper retrofractum Vahl.) has antioxidant activity and contains piperine compounds that have anticancer activity. This study aims to assess the potential of long pepper fruit extract as a chemopreventive agent for cervical cancer. The research method was conducted by in silico assay with network pharmacology and molecular docking analysis. We found five hub genes including HSP90AA1, SRC, AKT1, STAT3, and PIK3CA. KEGG analysis showed that the most dominant signaling pathways involved are neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, MAPK signaling pathway, Calcium signaling pathway, and cAMP signaling pathway. Through molecular docking, it was found that long pepper fruit has the potential to inhibit the E6 oncogene of HPV. Based on the research results, long pepper fruit extract may has the potential as a chemoprevention agent for cervical cancer.Keywords: Cervical cancer, oncoprotein HPV16-E6, Piper retrofractum Vahl., molecular docking, network pharmacology.
Co-Authors Astuti, Ni Made Widi Dewi, Ni Komang Gita Listyari Diantari, Desak Made Dewi I Wayan Martadi Santika Kurniadinata, I Putu Bagus Lestari, Priyanka Mahindra, I Kadek Sindhu Satya Putra, I Gusti Ngurah Trisna Meyana Sari, Wayan Dianda Wulandari, Ni Made Widya