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All Journal Indonesian Journal of Anesthesiology and Reanimation (IJAR) Majalah Biomorfologi (Biomorphology Journal) JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH
Firmanto, Neissya Nastiti
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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MOLECULAR DOCKING OF Crocus sativus PHYTOCHEMICALS AGAINST INDUCIBLE NITRIC OXIDE SYNTHASE AND PHOSPHODIESTERASE-9 IN HEART FAILURE PRESERVED EJECTION FRACTION Yasmine, Syafira; Firmanto, Neissya Nastiti; Sabrina, Annisa Maya; Khaerunnisa, Siti
Majalah Biomorfologi Vol. 33 No. 1 (2023): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v33i1.2023.20-29

Abstract

Highlights1. Heart failure preserved ejection fraction increases the mortality rate every year.2. Definitive therapy for HFpEF is not well identified.3. Crocus sativus phytochemical has anti-inflammatory and cardioprotective effects due to iNOS and PDE-9 inhibition. AbstractBackground: Heart failure preserved ejection fraction (HFpEF) is a complex disease associated with metabolic disease as a risk factor. A previous study found an association between iNOS and PDE-9 with inflammation and myocardial fibrosis in HFpEF. Objective: This study aimed to identify the potential phytochemicals of Crocus sativus (Saffron) that can inhibit protein iNOS and PDE-9 based on a molecular docking study. Material and Method: A total of fifty phytochemicals were obtained from Dr. Duke's Phytochemical Database and IJAH IPB. Those phytochemicals were screened by using the PyRx application and followed with Lipinski's Rule of Five screening by using SWISS Adme. Ten phytochemicals with lowest binding energy for each protein were docked and visually analyzed using Autodock 4.2 and BIOVIA Discovery Studio Visualizer 2016. Results: The best binding energy between protein-phytochemicals were -9.17 kcal/mol and -8.55 kcal/mol for iNOS and -9.17 kcal,/mol and -9.08 kcal/mol for PDE-9. Conclusion: Delphinidine and malvidin are the recommended inhibitors against iNOS and PDE-9 and must be investigated in further research.
Parent's Level of Stress on Children's Online Classes during the COVID-19Pandemic Nurrosyida, Kartika; Firmanto, Neissya Nastiti; Fayanshah, Irda Bella Ajeng; Sulistyawati, Sri Wijayanti
Journal of Community Medicine and Public Health Research Vol. 3 No. 1 (2022): Journal of Community Medicine and Public Health Research
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (201.253 KB) | DOI: 10.20473/jcmphr.v3i1.32611

Abstract

The Covid-19 pandemic is affecting people's lives. One of the sectors hampered by the pandemic is education. During the Coronavirus Disease (Covid-19) Emergency, the teaching and learning process must be replaced by online methods. The role of mothers is very important in ensuring that children's learning targets are achieved during distance learning. This can cause stress conditions for the mother. This study aimed to determine the perceptions and various problems that occurred in mothers with children aged 7-15 years old who attended online schools during the Covid-19 pandemic. This was a descriptive study by distributing questionnaires via google form with 67 respondents. Based on the results, the majority of respondents were 35-45 years old (49.3%). Over 85.6% of respondents accompanied their children in online learning activities during the pandemic. The majority of respondents experienced an increase in emotions (70.1%) and felt stressful when accompanying online school children during the pandemic (62.7%). As many as 40% of respondents felt a moderate level of stress. There were 27 mothers (40%) who had difficulty assisting their children in online schooling and 24 mothers (36%) felt that their professional job was abandoned while their children were having online school.
Severe Preeclamptic Patients in The Resuscitation Room of Dr. Soetomo General Academic Hospital Surabaya: A Retrospective Study Firmanto, Neissya Nastiti; Maulydia; Mulawardhana, Pungky; Fitriati, Mariza
Indonesian Journal of Anesthesiology and Reanimation Vol. 4 No. 2 (2022): Indonesian Journal of Anesthesiology and Reanimation (IJAR)
Publisher : Faculty of Medicine-Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijar.V4I22022.62-71

Abstract

Introduction: Preeclampsia is the leading cause of maternal and fetal death. This is an urgency in maternal health, especially in developing countries such as Indonesia. Patients with severe preeclampsia who had critical conditions tend to be admitted to the resuscitation room for assistance from more skilled personnel and more sophisticated technology. Objective: This study aims to determine the complications, treatments, and outcomes of severe preeclampsia patients managed in the resuscitation room at Dr. Soetomo General Academic Hospital from January 1st, 2018 – December 31th 2019. Methods: The method used in this study was retrospective descriptive using medical records and analyzed using Microsoft Excel. Eighty-one samples met the inclusion criteria. Results: The majority of patients were aged 20-35 years (65.43%) and had completed senior high school (88.89%). Most patients were having stage 2 obesity (44.44%) and multigravida (41.97%). A history of preeclampsia and hypertension was not found in the majority of patients. Most patients are diagnosed with late-onset preeclampsia (69.14%). The majority of patients were referred from secondary health facilities (96.30%). The most common complication was pulmonary edema(53.09%). The majority of patients had 2 complications (43.17%) with the most common combinations being eclampsia and HELPP syndrome (13.58%). Intubation is given to the majority of patients (70.37%) and most often in patients with eclampsia (56.14%). Termination of pregnancy by cesarean section is carried out in the majority of patients (72.84%). There were no cases of maternal death in this study. Most of the fetal born had prematurity (70.11%), low birth weight (60%), and asphyxia as assessed by the first minute APGAR score (72.97%) and fifth minute APGAR score (54.05%). Conclusion: The majority of preeclampsia patients with complications in the resuscitation room at Dr. Soetomo General Academic Hospital Surabaya from January 1st 2018-December 31rd 2019 had good maternal outcomes but not the fetal outcome.
Co-Authors Fayanshah, Irda Bella Ajeng Fitriati, Mariza Khaerunnisa, Siti Maulydia Nurrosyida, Kartika PUNGKY MULAWARDHANA, PUNGKY Sabrina, Annisa Maya Sriwijayanti Sulistyawati Yasmine, Syafira