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All Journal Archives of The Medicine and Case Reports
Kasmuddin
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Health Professions Medicine & Pharmacology Nursing Public Health

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Detection of SARS-CoV-2 Genes in Stool Samples of COVID-19 Survivors Using the Real-Time Reverse Transcriptase Polymerase Chain Reaction Method Ka’bah; Nur Laela Alydrus; Arlitha Dekayana; Kasmuddin; Rinaldi Indra Duma’ari
Archives of The Medicine and Case Reports Vol. 5 No. 1 (2024): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v5i1.453

Abstract

The spread of a pneumonia outbreak infected with the new coronavirus (COVID-19) from Wuhan, China, has spread globally. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified as the pathogen responsible for the pneumonic plague. The angiotensin conversion enzyme (ACE2) is the cellular receptor for SARS-CoV-2 entry. ACE2 is highly expressed in the epithelium of the stomach, duodenum and rectum. In infected patients, some patients infected with SARS-CoV-2 experience unusual symptoms, namely gastrointestinal symptoms, namely diarrhea, nausea and vomiting. This study aims to detect the presence of the SARS-CoV-2 gene in stool samples from COVID-19 survivors using the method real time RT-PCR as the gold standard for confirming COVID-19 with the RdRp and Helicase (ORF1b) target genes. There were 12 samples of COVID-19 survivors who met the inclusion criteria. The results showed that of the 12 samples, 2 samples were positive for SARS-CoV-2 RNA with Ct values of 32.79 and 36.86 which were detected on days 18 and 22 days after their respiratory tract tests were negative.
Prevalence of Enterotoxigenic Escherichia coli -LT Gene Expression in Pediatric Diarrhea Patients in Makassar City, Indonesia: A Cross-Sectional Study Alydrus, Nur Laela; Ka’bah; Kasmuddin; Prelly Loupatti
Archives of The Medicine and Case Reports Vol. 5 No. 4 (2024): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v5i4.612

Abstract

Enterotoxigenic Escherichia coli (ETEC) is a significant cause of diarrheal disease worldwide, particularly in children. The heat-labile toxin (LT) is a crucial virulence factor encoded by the LT gene. This study investigated the prevalence of ETEC LT gene expression in children with diarrhea in Makassar City, Indonesia. A cross-sectional study was conducted from January 2023 to December 2023. Rectal swabs were collected from children under five years of age presenting with diarrhea at outpatient clinics in Makassar. DNA was extracted, and the presence of the ETEC LT gene was detected using polymerase chain reaction (PCR). Demographic and clinical data were collected via questionnaires. The ETEC LT gene was detected in 81 (18%) children. The prevalence was significantly higher in children under one year of age (51%) compared to older age groups. ETEC LT positive children were more likely to experience vomiting and fever. ETEC expressing the LT gene contributes to a significant proportion of pediatric diarrhea cases in Makassar. The higher prevalence in younger children highlights the vulnerability of this age group. These findings emphasize the need for improved sanitation and hygiene practices to reduce ETEC transmission.
Co-Authors Alydrus, Nur Laela Arlitha Dekayana Ka’bah Nur Laela Alydrus Prelly Loupatti Rinaldi Indra Duma’ari