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All Journal Dental Journal (Majalah Kedokteran Gigi) E-Prodenta Journal of Dentistry
Junivianti, Hana Salsabila
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Dentistry Health Professions Medicine & Pharmacology

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SINTESIS NANOHIDROKSIAPATIT TURUNAN CANGKANG TELUR SEBAGAI PENGGANTI CANGKOK UNTUK REGENERASI TULANG DALAM KEDOKTERAN GIGI: STUDI LITERATUR Wardani, Sinta Candra; Rujati, Binar; Nuraprilla, Efourtharista; Junivianti, Hana Salsabila; Wibowo, Marchella Anestya; Rahmatina, Sania Putri
E-Prodenta Journal of Dentistry Vol 8 No 1 (2024)
Publisher : Fakultas Kedokteran Gigi UB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.eprodenta.2024.008.01.7

Abstract

Latar belakang: Kerusakan tulang yang disebabkan oleh trauma dan penyakit memiliki kemampuanterbatas untuk memperbaiki diri sendiri. Banyak peneliti telah mencoba untuk memperbaiki jaringantulang yang rusak dan mengembalikan fungsi melalui penggunaan biomaterial sel. Cara yang efektifuntuk mengatasi kebutuhan ini adalah melalui grafting yang dirancang untuk membantu regenerasitulang. Tujuan: Melihat keberhasilan sintesis nano hidroksiapatit cangkang telur sebagai bahan graftdalam regenerasi tulang. Metode: Literatur diperoleh dari database antara lain PubMed, ScienceDirect,ARC Journal of Dental Science dan Google Scholar. Jurnal yang digunakan pada penulisan inimerupakan jurnal yang diterbitkan 10 tahun terakhir, jurnal berbahasa Inggris dan Bahasa Indonesia,literature teks lengkap berupa original research, review, dan case report. Hasil: Didapatkan 12 artikeldari hasil pencarian literatur. Nano hidroksiapatit yang disintesa dengan berbagai metode dari cangkangtelur telah diuji karakterisasinya serta aplikasinya baik secara in vitro maupun secara klinis.Kesimpulan: Sintesis cangkang telur nano hidroksiapatit berpotensi baik sebagai pilihan bahanpengganti graft untuk meregenerasi tulang khususnya di kedokteran gigi.
The effect of nanoparticle tooth grafts on osteoblast stimulation in the first stages of the bone healing process in Wistar rats compared to the micro-tooth graft technique Kumala, Ega Lucida Chandra; Fauzia, Malianawati; Junivianti, Hana Salsabila
Dental Journal (Majalah Kedokteran Gigi) Vol. 56 No. 3 (2023): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v56.i3.p184-188

Abstract

Background: The use of a bone graft in bone regeneration is challenging. Tooth graft material has been used as a bone graft alternative due to its similar composition of organic and inorganic materials close to the bone. Recently, nanotechnology has been used to improve bone graft quality. The osteoconduction rate in the defect area represents the bone graft quality. Purpose: This study aimed to compare the number of osteoblasts using nano-tooth grafts and micro-tooth grafts in Wistar rats. Methods: Wistar rats were divided into six groups: the negative control groups (examined on days 7 and 14), the micro-tooth graft groups (examined on days 7 and 14), and the nano-tooth graft groups (examined on days 7 and 14). The control group received nothing, the micro-tooth group received a micro-size tooth graft, and the nano-tooth graft group received a nano-size tooth graft on the injured femur. Histological observations of osteoblasts were carried out using a light microscope with 1000x magnification. Data were analyzed using one-way analysis of variance and least significant difference tests. Results: On day 7, the nano-tooth graft group showed a higher osteoblast number (11.75) than the micro-tooth graft group (7.5) (p = 0.039). There was no significant difference in the micro-tooth graft group compared to the control (p > 0.05). On day 14, the nano-tooth graft group showed a decrease in osteoblast number close to normal (control) (p > 0.05), while the micro-tooth graft group still experienced significant elevation. Conclusion: Nano-tooth grafts accelerate the stimulation of osteoblasts in the first stages of the healing process compared to micro-tooth grafts.
Co-Authors Fauzia, Malianawati Kumala, Ega Lucida Chandra Nuraprilla, Efourtharista Rahmatina, Sania Putri Rujati, Binar Wardani, Sinta Candra Wibowo, Marchella Anestya