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A ANALISIS KELAYAKAN MODEL BIOMEDIS EKSPERIMENTAL PADA KASUS DIABETES MELLITUS MENGGUNAKAN MODEL ORGANISME IKAN ZEBRA (Danio rerio) A. Yashilva, Willy; Septia Rosdiana, Delita; Syafina, Indira Aulia; Cahyadi, Yusuf; Hendroyono, Farrah Lula Klarissa
Jurnal Mitra Kesehatan Vol. 6 No. 2 (2024): Jurnal Mitra Kesehatan
Publisher : STIKes Mitra Keluarga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47522/jmk.v6i2.305

Abstract

Introduction : Animal models are essential for research into diabetes, as they allow scientists to study the disease in a controlled environment. Small freshwater fish known as zebrafish (Danio rerio) are being employed more and more as model organisms in studying human diseases. They are genetically similar to humans, and they share many of the same metabolic pathways. This study aims to assess the viability of utilizing zebrafish as a model organism in the study of diabetes mellitus. Method: This study was examined in three databases, including Google Scholar, PubMed, and Scopus, and 19 publications were included. For that database, we ran the following search query in the titles. A literature review was performed in this study, and Prisma flow diagrams were employed to enhance the clarity and transparency of the review process. A method for summarizing the characteristics of the Zebrafish that make it a desirable model organism for Diabetes Mellitus research. Result: The findings of this study show that zebrafish may be used to investigate the genetics, development, and treatment of diabetes since their glucose metabolism and reactive metabolite production pathways are remarkably similar to those of humans. Similar findings were made regarding the functional conservation in adipose biology, pancreatic anatomy, lipid metabolism, and glucose homeostasis. Conclusion:The conclusion of this study is that the Zebrafish can be used as one of the animal models for identifying new targets for the precaution and medication of diabetes mellitus.
Relation Between Fast Food and Preservative Consumption with Rheumatoid Arthritis Pain in A Gymnastics Group in Bandung City Syafina, Indira Aulia; Syah, Bagas Dwi; Ainunnisa, Rista Utami; Nurlaila, Syahnaz; Fitrianingsih, Asti Dewi Rahayu
Journal of Applied Food and Nutrition Vol 5, No 1 (2024)
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/jafn.v5i1.69999

Abstract

Background: Rheumatoid arthritis is an autoimmune disease in the form of joint inflammation in adults. Based on the 2018 WHO report, it shows that there are 335 million people in the world who have rheumatism, of which 5-10% are aged 5-20 years and 20% are aged 55 years. Factors that can cause pain in rheumatoid arthritis are dietary factors, one of which is frequent consumption of fast food and preserved foods. The aim of this study was to determine the relationship of consumption of fast food and preserved foods to rheumatoid arthritis complaints in two gymnastics groups in Bandung City.Methods: This study used a cross-sectional design with a sample of 30 gymnastic ladies taken by purposive sampling. Data were analyzed using the Chi-Square test with IBM SPSS Statistic 21 software.Results: Based on the results of the analysis that has been done, there is no relationship between age, educational history, consumption of fast food and preserved food with rheumatoid arthritis complaints in the group of gymnastics ladies in Bandung City (p0,05).Conclusions: The absence of an association among age, educational history, consumption of fast food and preserved foods with rheumatoid arthritis complaints can be due to other factors outside of these factors such as genetics, gender, obesity, infectious diseases, and lack of knowledge about rheumatoid arthritis. What's more, rheumatoid arthritis is also a multifactorial disease, so we need to wisely maintain and regulate  his, her, their, etc lifestyle and food intake so that rheumatoid arthritis complaints can be minimized and do not have recurrences.