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A ANALISIS KELAYAKAN MODEL BIOMEDIS EKSPERIMENTAL PADA KASUS DIABETES MELLITUS MENGGUNAKAN MODEL ORGANISME IKAN ZEBRA (Danio rerio) A. Yashilva, Willy; Septia Rosdiana, Delita; Syafina, Indira Aulia; Cahyadi, Yusuf; Hendroyono, Farrah Lula Klarissa
Jurnal Mitra Kesehatan Vol. 6 No. 2 (2024): Jurnal Mitra Kesehatan
Publisher : STIKes Mitra Keluarga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47522/jmk.v6i2.305

Abstract

Introduction : Animal models are essential for research into diabetes, as they allow scientists to study the disease in a controlled environment. Small freshwater fish known as zebrafish (Danio rerio) are being employed more and more as model organisms in studying human diseases. They are genetically similar to humans, and they share many of the same metabolic pathways. This study aims to assess the viability of utilizing zebrafish as a model organism in the study of diabetes mellitus. Method: This study was examined in three databases, including Google Scholar, PubMed, and Scopus, and 19 publications were included. For that database, we ran the following search query in the titles. A literature review was performed in this study, and Prisma flow diagrams were employed to enhance the clarity and transparency of the review process. A method for summarizing the characteristics of the Zebrafish that make it a desirable model organism for Diabetes Mellitus research. Result: The findings of this study show that zebrafish may be used to investigate the genetics, development, and treatment of diabetes since their glucose metabolism and reactive metabolite production pathways are remarkably similar to those of humans. Similar findings were made regarding the functional conservation in adipose biology, pancreatic anatomy, lipid metabolism, and glucose homeostasis. Conclusion:The conclusion of this study is that the Zebrafish can be used as one of the animal models for identifying new targets for the precaution and medication of diabetes mellitus.
Correlation of energy intake and availability with aerobic endurance performance Hendroyono, Farrah Lula Klarissa; Sentani, Muchamad Rizky; Kumalasari, Isti; Rosdiana, Delita Septia
Multilateral : Jurnal Pendidikan Jasmani dan Olahraga Vol 25, No 1 (2026): February
Publisher : Lambung Mangkurat University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/multilateral.v25i1.24131

Abstract

Futsal is a high-intensity intermittent sport demanding optimal aerobic endurance and adequate nutritional support, particularly for adolescent athletes during growth. This study aimed to determine the relationship between nutrient intake, energy availability (EA), and aerobic endurance among futsal athletes in Bandung. A total of 47 male athletes aged 13-21 years from Futsal 15 Bandung participated in this cross-sectional study. Data collection included three 24-hour food recalls for dietary intake, anthropometric measurements, and the Multistage Fitness Test (Beep Test) for estimating VO2 max. Energy availability was calculated by subtracting exercise energy expenditure (EEE) from energy intake, normalized per fat-free mass (FFM). The results showed significant positive correlations between aerobic endurance, VO2 max, and intake levels of energy (p = 0.003, r = 0.427), carbohydrates (p = 0.003, r = 0.427), protein (p = 0.000, r = 0.514), and fluids (p = 0.002, r = 0.446). However, no significant correlation was found between EA (p = 0.700) or fat intake (p = 0.465) and VO2 max. Most athletes had low EA values (< 30 kcal/kg FFM/day), indicating potential nutritional risks. These findings highlight the importance of adequate macronutrient and fluid intake to support aerobic performance and professional nutritional intervention in athlete development programs.