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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Jurnal Klinik dan Riset Kesehatan
Faradila, Anandita
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Peran Centela Asiatica Sebagai Moisturizer Faradila, Anandita; Setyowatie, Lita
Jurnal Klinik dan Riset Kesehatan Vol 1 No 3 (2022): Edisi Juni
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.01.3.4

Abstract

Moisturizer merupakan komponen utama perawatan dasar kulit harian terutama jika terjadi perubahan sawar epidermal dan berkurangnya kandungan air di lapisan epidermis. Ketika jumlah air menurun hingga di bawah 10%, kulit akan menjadi kering. Beberapa tanaman obat yang berpengaruh terhadap hidrasi kulit salah satunya yaitu Centella asiatica. C. asiatica dikenal di Indonesia sebagai Pegagan dan termasuk dalam famili Umbelliferae/Apiaceae. Ekstrak dari daun C. asiatica telah dilaporkan berpotensi sebagai antioksidan, antimikroba, agen sintesis kolagen dan bahkan berperan sebagai penyembuh luka. Komponen aktif C.asiatica termasuk pentacyclic triterpenes, khususnya asiaticoside, madecassoside, asiatic acid and madecassic acid. C. asiatica digunakan sebagai senyawa aktif pada sediaan perawatan kulit karena bersifat menghidrasi kulit, antioksidan, antiradang, antiselulit, sifat antiinflamasi dan antipenuaan. Suatu formulasi yang mengandung konsentrasi ekstrak C. asiatica menunjukkan khasiat dalam meningkatkan kelembaban kulit dengan meningkatkan keadaan hidrasi permukaan kulit dan menurunkan terjadinya transepidermal water loss (TEWL). Tinjauan pustaka ini bertujuan menambah wawasan mengenai kandungan dan mekanisme kerja C. asiatica yang dapat dimanfaatkan sebagai moisturizer pada kulit. C. asiatica dapat digunakan sebagai formulasi kosmetik yang dapat merawat kulit kering dan sensitif. Lebih banyak penelitian diperlukan untuk mengenal dan menetapkan senyawa kimia C. asiatica yang bertanggung jawab atas berbagai aktivitas terapeutik, khususnya sebagai moisturizer yang efektif, aman, mudah dan murah.
Electrosurgery and 5% Imiquimod Cream as a Combination Therapy for Perianal Condyloma Acuminata in a HIV Patient Setyowatie, Lita; Faradila, Anandita
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 2 (2025): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V37.2.2025.142-146

Abstract

Background: Condyloma acuminata (CA) is a common sexually transmitted infection caused by the human Papillomavirus (HPV) infection. It is characterized by single or multiple lesions in the anogenital area accompanied by itching, discharge, or bleeding. CA in HIV (human immunodeficiency virus) - positive patients can experience a low response to various therapeutic modalities, which may lead to consideration of choosing combination therapy to increase the effectiveness of therapy. Case: We report a case in a twenty-one-year old male with multiple warts on the perianal area. Within four months, the warts had covered the perianal area, with hemorrhoids emerging as complications. The patient had trichloroacetic acid treatment three times but did not respond. The patient is male who have sex with male, and there has been a history of multisexual partners. The diagnosis was made by clinical and histopathological examinations. The patient is HIV-positive and has been receiving antiretrovirals regularly. He got a combination therapy of electrosurgery and 5% imiquimod cream for 9 weeks and showed excellent results. Discussion: Standard topical medication is an effective treatment for condyloma acuminata, but infiltrative and recurrent lesions often require ablative and surgical treatment. Conclusion: Electrosurgery in combination with imiquimod proved to be effective and shortening the treatment regimen in the treatment of perianal CA.
Peran Centela Asiatica Sebagai Moisturizer Faradila, Anandita; Setyowatie, Lita
Jurnal Klinik dan Riset Kesehatan Vol 1 No 3 (2022): Edisi Juni
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.01.3.4

Abstract

Moisturizer is the main component of daily basic skin care especially if there is a change in the epidermal barrier and reduced water content in the epidermis layer. When the amount of water drop below 10%, the skin become dry. One of herbal plants that affect skin hydration is Centella asiatica. C. asiatica is known as Pegagan in Indonesia and belongs to the Umbelliferae/Apiaceae family. Extracts from the leaves of C. asiatica have been reported to have potential as antioxidants, antimicrobial agents, collagen synthesis agents, and even act as wound healing properties. The active components of C. asiatica include pentacyclic triterpenes, particularly asiaticoside, madecassoside, asiatic acid and madecassic acid. C. asiatica is used as an active compound in skin care preparations due to its hydrating, antioxidant, anti-inflammatory, anti-cellulite and anti-aging activities. A formulation containing a concentration of C. asiatica extract showed efficacy in increasing skin moisture by increasing the hydration state of the skin surface and reducing the occurrence of transepidermal water loss (TEWL). This literature review aims to add insight about Centella asiatica and its mechanism of action that can be used as a moisturizer for the skin. Centella asiatica can be used as a cosmetic formulation that can treat dry and sensitive skin. More research is needed to identify and determine the chemical compound C. asiatica which is responsible for various therapeutic activities, especially as an effective, safe, easy and inexpensive moisturizer.
Co-Authors Lita Setyowatie, Lita