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All Journal Majalah Farmasetika Journal of Fundamental and Applied Pharmaceutical Science
Kumala Sari, Diah Indah
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Medicine & Pharmacology

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Studi Formulasi dan Karakteristik Fisik Serum Spray Kombinasi Ceramide dan Tea Tree Oil serta Uji Aktivitas Antioksidan Menggunakan Metode DPPH Sasmitasari, Diana; Pratiwi, Elasari Dwi; Kumala Sari, Diah Indah
Majalah Farmasetika Vol 9, No 2 (2024)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v9i2.49479

Abstract

Paparan sinar matahari menyebabkan kulit menjadi kusam karena mengandung radiasi sinar UV yang dapat merusak lapisan kulit. Penggunaan kosmetik yang mengandung senyawa antioksidan seperti ceramide dan tea tree oil dapat melindungi kulit dari paparan sinar matahari. Ceramide dapat memperkuat skin barrier dan mencegah hilangnya kelembapan kulit yang berfungsi sebagai antiaging dan memberikan efek perbaikan pada kulit dengan menghambat sebagian efek yang tidak diinginkan terkait penuaan. Tea tree oil merupakan agen antioksidan yang berfungsi untuk menangkap radikal bebas, bahan penangkap radikal bebas meliputi α-terpinene, α-terpinolene dan γ-terpinene. Tujuan dari penelitian ini adalah untuk membandingkan karakteristik fisik dan  nilai aktivitas antioksidan serum spray yang mengandung kombinasi zat aktif ceramide dan tea tree oil. Metode penelitian secara eksperimental dengan membuat formula sediaan serum spray kombinasi ceramide dan tea tree oil dengan variasi konsentrasi 0,5%, 0,75%, dan 1% kemudian dilakukan pengujian karakteristik fisik dan aktivitas antioksidan. Hasil evaluasi karakteristik fisik berpengaruh terhadap parameter warna, aroma, pH, viskositas, dan daya sebar, tetapi tidak berpengaruh terhadap parameter konsistensi dan homogenitas sediaan. Hasil evaluasi nilai aktivitas antioksidan dari masing-masing formula didapatkan nilai IC50 terhadap kontrol (+) ceramide sebesar 33,9 ppm, kontrol (+) TTO 43,92 ppm, F1 sebesar 28,77 ppm, F2 sebesar 27,34 ppm, F3 sebesar 15,26 ppm yang termasuk dalam kategori sangat kuat. Kesimpulan dari penelitian ini yaitu dengan adanya peningkatan konsentrasi ceramide dan tea tree oil memberikan pengaruh terhadap karakteristik fisik sediaan dan nilai Inhibition Concentration (IC50).
Optimization of the Mixing of Hibiscus Flower (Hibiscus rose sinensis) Extract as a Lip Balm Color with Variations in Concentration Kumala Sari, Diah Indah; Mayangsari, Fransisca Dita; Pratiwi, Elasari Dwi
Journal of Fundamental and Applied Pharmaceutical Science Vol 4, No 1 (2023): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i1.16179

Abstract

Hibiscus rosa sinensis L. is widely used by the community to decorate the garden because of its splendor. In addition, Hibiscus flowers containing anthocyanin and flavonoids have antioxidants, which function as antioxidants against free radicals. This natural dye can be obtained by extracting Hibiscus flowers through maceration using 96% ethanol. In this research, Hibiscus flowers were obtained from Sendang Rejo Village, Lamongan Regency. In the extract process, the Hibiscus flower’s petals were blended until smooth, then added to 96% ethanol (1 liter) and stirred for 30 minutes. Filtrate results were taken, placed in a porcelain dish, and put in an oven at 60 °C for a day. Four formulas were made with varying levels of Hibiscus flower extract: F1 (0%), F2 (2%), F3 (4%), and F4 (6%). Physical evaluation included organoleptic, homogeneity, dispersibility, pH, and qualitative tests for the identification of anthocyanins. The results of the organoleptic, homogeneity, dispersion, pH, and identification of anthocyanins evaluations were then analyzed descriptively. The data from the organoleptic test indicated that F1 had an odorless white color, while F2, F3, and F4 had a red and white color with a distinctive Hibiscus flower aroma. The homogeneity test revealed that while F1 had good homogeneity, F2, F3, and F4 were not homogeneous (heterogeneous). The spreadability test on the four formulas did not fall within the range of requirements, namely 5-7 cm, with an average value of 3.53, but this was related to several significant reasons. In addition, the pH test results matched the requirements for topical preparations, namely 4.5–6.5, with an average value of 5.075. In conclusion, Hibiscus flower extract obtained through the maceration method with 96% ethanol could not give a homogeneous red color from the anthocyanin substance. Physical evaluation and anthocyanin identification tests also obtained good results.
Co-Authors ELASARI DWI PRATIWI, ELASARI DWI Fransisca Dita Mayangsari Sasmitasari, Diana