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All Journal E-Jurnal Medika Udayana Bioscientist : Jurnal Ilmiah Biologi International Journal of Multidisciplinary Approach Research and Science
yulia, inelvi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Social Sciences

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FORMULASI EKSTRAK ETANOL SABUN CAIR CITRUS SINENSIS SEBAGAI ANTIJAMUR TERHADAP CANDIDA ALBICANS yulia, inelvi; niken, Niken
E-Jurnal Medika Udayana Vol 13 No 9 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i09.P07

Abstract

Candidiasis merupakan infeksi yang terjadi pada 20-25% populasi dunia. Diperkirakan prevalensi infeksi oleh Candida albicans mencapai 25.000 kasus setiap tahun. Candida albicans dapat bersifat opurtunistik, menyerang organ dalam tubuh manusia seperti jantung, paru-paru, ginjal dan dibawa melalui aliran darah sehingga menyebabkan gejala yang sangat parah. Terapi yang dilakukan untuk mengobati Candidiasis diantaranya pemberian obat sintetis seperti obat antijamur. Namun beberapa obat memberikan efek samping yang mengganggu seperti mual, muntah sampai rasa terbakar pada kulit. Penelitian ini bertujuan untuk untuk memformulasikan dan meguji efektivitas antifungi sediaan sabun cair dari ekstrak etanol kulit Citrus sinensis terhadap pertumbuhan Candida albicans penyebab Candidiasis secara in vitro. Metode yang digunakan adalah penelitian ekperimental laboratorium dengan menggunakan uji One-Way Analysis of Variance (ANOVA). Analisis akan dilakukan terhadap daya hambat sediaan sabun cair ekstrak etanol kulit Citrus sinensis terhadap pertumbuhan Candida albicans secara in vitro dan karakter organoleptik sabun cair. Hasil penelitian ini menunjukkan bahwa ekstrak etanol kulit Citrus sinensis dapat diformulasikan menjadi sediaan sabun cair dengan beberapa karakter yang sesuai dengan standar nasioan Indonesia sebagai sabun cair. Formulasi I sediaan sabun cair ekstrak kulut Citrus sinensis memiliki daya hambat yang paling besar daripada formulasi yang lain. Semua formulasi dapat menghambat pertumbuhan Candida albicans secara in vitro dengan kategori kuat hingga sangat kuat. Kesimpulan dari penelitian ini yaitu ekstrak kulit Citrus sinensis dapat diformulasikan menjadi sabun cair dan memiliki aktivitas antifungi terhadap Candida albicans yang dikategorika kuat hingga sangat kuat. Kata kunci : Formulasi sediaan sabun cair., Kulit Citrus sinensis., Candida albicans
Innovation of extract (Lawsonia Inermis L) as alternative dye for Escherichia Coli bacterial staining Niken, Niken; Yulia, Inelvi
International Journal of Multidisciplinary Approach Research and Science Том 1 № 03 (2023): International Journal of Multidisciplinary Approach Research and Science
Publisher : Pt. Riset Press International

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59653/ijmars.v1i03.274

Abstract

Escherichia coli (E.coli) is a group of gram-negative bacteria that are part of the normal flora in the body. Under certain conditions, these bacteria can be pathogenic by producing enterotoxins that can cause serious infections such as diarrhea. Establishing the diagnosis of infection due to E.coli bacteria, namely through laboratory tests by identifying the bacteria through the bacterial staining method. So far, the most widely used bacterial dyes are synthetic dyes such as safranin. Safranin is a dye in Gram stain which can be carcinogenic and in the long run has a negative impact on health. To overcome this problem, it is necessary to innovate natural dyes that can be used as alternative dyes. Leaves of henna nails (Lawsonia inermis L.) is one of the natural ingredients which has an orange-orange lawsone pigment that is able to color the cell walls of gram-negative bacteria such as E.coli. The purpose of this study was to determine the ability of henna leaf extract (Lawsonia inermis L.) as an alternative to safranin staining. This research is a laboratory experiment. The experimental group was stained with henna leaf extract, using ethanol solvent concentrations of 25 mg/ml, 50 mg/ml, 75 mg/ml and 100 mg/ml. The control group used safranin dye. All research groups were carried out 3 repetitions. The parameters used were the clarity of the visual field, the shape of the bacteria, the cleanliness of the preparation and the color of the bacteria compared to the safranin control. The results showed that henna leaf extract was effective enough to be used as a coloring agent to replace safranin because it can color E.coli bacteria well.
Uji Aktivitas Antifungi Kombinasi Ekstrak Etanol Kulit Pisang Kepok (Musa paradisiaca L.) dan Kulit Jeruk Manis (Citrus sinensis) terhadap Candida albicans Penyebab Keputihan Patologis Secara In Vitro Yulia, Inelvi; Prima, Heppy Setya
Bioscientist : Jurnal Ilmiah Biologi Vol 11, No 2 (2023): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v11i2.9360

Abstract

Pathological vaginal discharge (Candidiasis) is a reproductive health problem experienced by more than 50% of women throughout the world. Candida albicans is the main cause of pathological vaginal discharge. This disease is characterized by yellow to greenish discharge, odor, and itching to the point of bleeding which can cause death. Antifungal drugs used to treat pathological vaginal discharge can have several side effects. Therefore, the urgency of this research is to find natural alternatives for pathological vaginal discharge drugs, such as sweet orange peel and kepok banana peel which contain bioactive compounds that can inhibit the growth of Candida albicans. The aim of this study was to test the antifungal activity of a combination of ethanol extracts of sweet orange peel and kepok banana peel against Candida albicans in vitro. This research uses laboratory experimental methods. The results showed that all combinations of ethanol extracts of sweet orange peel and kepok banana peel could inhibit the growth of Candida albicans. The inhibitory power of each extract combination is categorized as moderate to very strong. According to the one-way ANOVA statistical test, all combinations were significantly different (p < 0.05). The ethanol extract of sweet orange peel contains flavonoids, alkaloids, phenolics and steroids, while the kepok banana peel extract contains phytochemical compounds such as flavonoids, phenolics, triterpenoids and alkaloids.
Co-Authors Heppy Setya Prima Niken Niken