Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Jurnal Mandala Pharmacon Indonesia Jurnal farmasi UIN Alauddin Makassar
Sauma, Anis Khoirun
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Hubungan Resistensi Antibiotik Pada Pasien Sepsis dan COVID-19 : Literatur Review Amir, Nur Rezky Rutami; Sauma, Anis Khoirun; Kurnia Eryani; peppy dwi endraswari
Jurnal Farmasi UIN Alauddin Makassar Vol 12 No 1 (2024): Jurnal Farmasi Edisi Mei
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jfuinam.v12i1.42468

Abstract

Background: COVID-19 disease with secondary infection especially, and should be treated immediately with exact antibiotics related to the patient's condition to return the patient's hemodynamics. The consumption of antibiotics that are imprecise, and not based on method will cause antibiotic resistance, and it will increase the illness, elevating the complications, and mortality. Objective: This literature research is aimed to explore the relationship between the consumption of antibiotics toward sepsis and COVID-19 patients. Methods: This research applied a literature review method by using primary and secondary data and specifically using the database from article research such as Google Scholar Science Direct, MDPI, Elsevier, NCBI, Springer, Taylor and Francis, Oxford Academic, and Higher Press related on the inclusion. Results: During the data collection session, five articles were analysed specifically for entering the data PICO table (Population, Intervention, Comparison, and Outcome) and concluded each article. The result implies that the condition of patients who have COVID-19 in ICU/HCU is risky to have a secondary infection or co-infection such as sepsis, this condition requires precise antibiotics.Conclusion: The utilization of antibiotics that are used empirically or de-escalated can cause a risk for the application of various antibiotics and cause a risk of resistance. Several research indicate the resistance of antibiotics used by COVID-19 patients and sepsis due to the imprecise and overuse of antibiotics, the existence of co-infection, comorbid and the influence of intensive patient’s environment.
Influence of CYP2C19 Metabolism and Ethnic Variability on Clopidogrel Effectiveness in Ischemic Stroke: A Review Khotib, Junaidi; Sauma, Anis Khoirun
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.1024

Abstract

Clopidogrel is widely used to prevent secondary stroke and coronary heart disease. Its effectiveness depends on conversion to the active metabolite, a process mediated by cytochrome P450 2C19 (CYP2C19). Clopidogrel is less effective in secondary stroke prevention for carriers of CYP2C19 loss-od-function (LoF) alleles. This review examined research from 2019 to 2024 on how CYP2C19 enzyme metabolism affects clopidogrel’s effectiveness across ethic group and the resulting clinical outcomes in patients with ischemic stroke. A literature review was conducted using online research journals, with the population, intervention, comparison, and outcomes framework guiding the research questions. Ten studies were identified, primarily cohort studies, supplemented by several randomized control trials, which strengthen the evidence base. Most data came from Asian population with 1 – 2 LoF alleles (*2 and/or *3), including intermediate metabolizers (IM) or poor metabolizers (PM). The *1 allele was common in Europeans and Africans but found less frequently in Asians. Caucasian, European, African, and American populations were likely to carry gain-of-function alleles or be normal metabolizers. Bleeding risks did not differ significantly between carriers and noncarriers of the CYP2C19 LoF allele. In IM and PM, alternative P2Y12 inhibitors, such as prasugrel or ticagrelor, are recommended to optimize therapy.
Co-Authors Amir, Nur Rezky Rutami Junaidi Khotib Kurnia Eryani peppy dwi endraswari