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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research
Yoshie Anto Chicamy
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

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Overview of Bacterial Profile of Bloodstream Infections in the Intensive Care Unit (ICU): Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Rara Puspita Impelleren; Yulia, Dwi; Yoshie Anto Chicamy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 8 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i8.1055

Abstract

Background: Bloodstream infection (BSI) is a condition characterized by positive blood cultures in patients who have systemic infections. Bloodstream infections have developed into a threat to public health worldwide with high mortality rates in intensive care settings. This study aims to determine the bacterial profile of BSI in the intensive care unit (ICU) of Dr. M. Djamil General Hospital Padang. Methods: This study is a retrospective descriptive study with a cross-sectional design from secondary data at the Microbiology and Medical Records Installation Laboratory of Dr. M. Djamil General Hospital Padang. All blood samples from patients aged ≥18 years in the ICU who are suspected of being infected will be cultured and identified with VITEK 2 in 2022. Results: A total of 243 blood samples consisted of 126 men (52%) and 117 women (48%) with the largest age range being 41-60 years (48%). The diagnosis of BSI was found in 94% with the most common comorbidities being malignancy (42%) and stroke (15%). The most common bacterial bloodstream infections were found in the ICU of Dr. M. Djamil General Hospital Padang., namely Gram-positive bacteria (66%) and coccus (66%). The most common type of bacteria identified with the VITEK 2 automatic tool is Staphylococcus hominis. Multidrug-resistant organisms (MDRO) found in this study were 8% with the most common causes, namely extended spectrum B-lactamase (ESBL). Blood samples in this study found bacteria due to contamination by 38%. Conclusion: The BSI bacterial profile found was mostly in the ICU of Dr. M. Djamil General Hospital Padang is a Gram-positive bacterium, coccus-shaped, Staphylococcus hominis and ESBL. Blood cultures found bacteria contaminated by 38%.
The Clinical Significance of DAT Positivity: A Comparative Analysis of IgG, C3d, and IgG/C3d-Positive Patients Khaulah Karimah; Zelly Dia Rofinda; Husni; Rikarni; Deswita Sari; Yoshie Anto Chicamy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1288

Abstract

Background: The direct antiglobulin test (DAT) is a crucial diagnostic tool in immunohematology, used to detect the presence of antibodies and/or complement components on the surface of red blood cells. DAT positivity is frequently associated with autoimmune hemolytic anemia (AIHA) and other immune-mediated hemolytic conditions. This study aimed to investigate the clinical significance of DAT positivity by comparing the characteristics of patients with IgG, C3d, and IgG/C3d-positive results. Methods: A retrospective study was conducted on 55 patients with DAT-positive results, identified from the Blood Transfusion Unit of Dr. M. Djamil General Hospital Padang between June 2023 and August 2023. DAT-positive samples were further analyzed using monospecific anti-human globulin (AHG) reagents to determine the presence of IgG, C3d, or both on the red blood cells. Patient demographics, clinical diagnoses, blood groups, transfusion history, and hematological parameters were collected and analyzed. Results: Out of the 55 DAT-positive patients, 51 (92.7%) were positive for IgG alone, 3 (5.5%) were positive for both IgG and C3d, and only 1 (1.8%) was positive for C3d alone. The majority of patients were adults (>18 years old) and female. A history of blood transfusion (>3 times) was common, particularly in the IgG-positive group. Hematological parameters indicative of hemolysis (hemoglobin ≤9 g/dL, reticulocyte count >2%, and total bilirubin >2 mg/dL) were observed in a significant proportion of patients, especially those with IgG and/or C3d positivity. Conclusion: IgG positivity was the most common finding in DAT-positive patients, highlighting the prevalence of warm AIHA. The presence of C3d, alone or with IgG, suggests the involvement of complement activation and may indicate a different underlying pathology. This study emphasizes the importance of using monospecific AHG reagents to characterize DAT-positive results, as this information can aid in the diagnosis, management, and prediction of clinical outcomes.
The Clinical Significance of DAT Positivity: A Comparative Analysis of IgG, C3d, and IgG/C3d-Positive Patients Khaulah Karimah; Zelly Dia Rofinda; Husni; Rikarni; Deswita Sari; Yoshie Anto Chicamy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1288

Abstract

Background: The direct antiglobulin test (DAT) is a crucial diagnostic tool in immunohematology, used to detect the presence of antibodies and/or complement components on the surface of red blood cells. DAT positivity is frequently associated with autoimmune hemolytic anemia (AIHA) and other immune-mediated hemolytic conditions. This study aimed to investigate the clinical significance of DAT positivity by comparing the characteristics of patients with IgG, C3d, and IgG/C3d-positive results. Methods: A retrospective study was conducted on 55 patients with DAT-positive results, identified from the Blood Transfusion Unit of Dr. M. Djamil General Hospital Padang between June 2023 and August 2023. DAT-positive samples were further analyzed using monospecific anti-human globulin (AHG) reagents to determine the presence of IgG, C3d, or both on the red blood cells. Patient demographics, clinical diagnoses, blood groups, transfusion history, and hematological parameters were collected and analyzed. Results: Out of the 55 DAT-positive patients, 51 (92.7%) were positive for IgG alone, 3 (5.5%) were positive for both IgG and C3d, and only 1 (1.8%) was positive for C3d alone. The majority of patients were adults (>18 years old) and female. A history of blood transfusion (>3 times) was common, particularly in the IgG-positive group. Hematological parameters indicative of hemolysis (hemoglobin ≤9 g/dL, reticulocyte count >2%, and total bilirubin >2 mg/dL) were observed in a significant proportion of patients, especially those with IgG and/or C3d positivity. Conclusion: IgG positivity was the most common finding in DAT-positive patients, highlighting the prevalence of warm AIHA. The presence of C3d, alone or with IgG, suggests the involvement of complement activation and may indicate a different underlying pathology. This study emphasizes the importance of using monospecific AHG reagents to characterize DAT-positive results, as this information can aid in the diagnosis, management, and prediction of clinical outcomes.
Overview of Bacterial Profile of Bloodstream Infections in the Intensive Care Unit (ICU): Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Rara Puspita Impelleren; Yulia, Dwi; Yoshie Anto Chicamy
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 8 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i8.1055

Abstract

Background: Bloodstream infection (BSI) is a condition characterized by positive blood cultures in patients who have systemic infections. Bloodstream infections have developed into a threat to public health worldwide with high mortality rates in intensive care settings. This study aims to determine the bacterial profile of BSI in the intensive care unit (ICU) of Dr. M. Djamil General Hospital Padang. Methods: This study is a retrospective descriptive study with a cross-sectional design from secondary data at the Microbiology and Medical Records Installation Laboratory of Dr. M. Djamil General Hospital Padang. All blood samples from patients aged ≥18 years in the ICU who are suspected of being infected will be cultured and identified with VITEK 2 in 2022. Results: A total of 243 blood samples consisted of 126 men (52%) and 117 women (48%) with the largest age range being 41-60 years (48%). The diagnosis of BSI was found in 94% with the most common comorbidities being malignancy (42%) and stroke (15%). The most common bacterial bloodstream infections were found in the ICU of Dr. M. Djamil General Hospital Padang., namely Gram-positive bacteria (66%) and coccus (66%). The most common type of bacteria identified with the VITEK 2 automatic tool is Staphylococcus hominis. Multidrug-resistant organisms (MDRO) found in this study were 8% with the most common causes, namely extended spectrum B-lactamase (ESBL). Blood samples in this study found bacteria due to contamination by 38%. Conclusion: The BSI bacterial profile found was mostly in the ICU of Dr. M. Djamil General Hospital Padang is a Gram-positive bacterium, coccus-shaped, Staphylococcus hominis and ESBL. Blood cultures found bacteria contaminated by 38%.
Co-Authors Deswita Sari Husni Khaulah Karimah Rara Puspita Impelleren Rikarni Yulia, Dwi Zelly Dia Rofinda