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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Healthy Tadulako Journal (Jurnal Kesehatan Tadulako)
Harvindra, Astrid
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Different Sepsis Patient Outcomes Due to Multidrug-Resistant Organisms (MDRO): A Study of Empirical Antibiotic Sensitivity Test Results Fadrian, Fadrian; Ahmad, Armen; Harvindra, Astrid; Putri, Vidola Yasena
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i3.1740

Abstract

Background: Sepsis, a severe immune response to infection, has a concerning global mortality rate of 85%, predominantly due to Gram-negative bacteria. The rise of antibiotic resistance in these organisms complicates treatment, leading to higher mortality and prolonged hospital stays. Effective empirical antibiotics can mitigate these outcomes. Objective: This study compares outcomes of sepsis patients infected with multidrug-resistant organisms (MDRO) based on empirical antibiotic sensitivity testing, focusing on mortality and length of stay (LOS) within 14 days of sepsis onset. Methods: A prospective cohort observational study at Dr. M. Djamil General Hospital included 94 participants. Patients who died within 14 days were excluded from the LOS analysis to prevent bias. Initial assessments included culture sampling and organ dysfunction. Results: The study revealed no significant difference in mortality based on antibiotic sensitivity (p=0.283), but the LOS was significantly shorter in those treated with sensitive antibiotics (p<0.016). Conclusion: LOS was significantly affected by antibiotic sensitivity, with patients receiving effective antibiotics experiencing shorter stays, though mortality differences were not statistically significant in the 14-day window
Meta-Analysis of Corticosteroids in the Management of Sepsis: Evaluating Efficacy and Safety Harvindra, Astrid; Armen Ahmad
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 11 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i11.1118

Abstract

Background: Sepsis remains a significant cause of morbidity and mortality worldwide. Corticosteroids have been used in sepsis management, but their efficacy and safety remain debated. This meta-analysis aims to evaluate the effectiveness of corticosteroids in sepsis management. Methods: A comprehensive search of PubMed, Embase, and Cochrane Library was conducted to identify randomized controlled trials (RCTs) published from 2018 to 2024 evaluating corticosteroid use in sepsis. The primary outcome was mortality. Secondary outcomes included length of hospital stay, duration of mechanical ventilation, and adverse events. Data were pooled using a random-effects model, and heterogeneity was assessed using the I² statistic. Results: Twenty-one RCTs (n=12,350 patients) were included. Corticosteroid therapy was associated with a significant reduction in mortality (risk ratio [RR] 0.87, 95% confidence interval [CI] 0.79-0.96, p=0.004). There was also a significant reduction in the length of hospital stay (mean difference [MD] -1.5 days, 95% CI -2.3 to -0.7, p<0.001) and duration of mechanical ventilation (MD -1.2 days, 95% CI -1.9 to -0.5, p<0.001). No significant increase in adverse events was observed. Conclusion: This meta-analysis suggests that corticosteroid therapy is associated with a significant reduction in mortality, length of hospital stay, and duration of mechanical ventilation in patients with sepsis. The benefits appear to outweigh the risks. Corticosteroids should be considered as part of the standard of care in sepsis management.
Meta-Analysis of Corticosteroids in the Management of Sepsis: Evaluating Efficacy and Safety Harvindra, Astrid; Armen Ahmad
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 11 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i11.1118

Abstract

Background: Sepsis remains a significant cause of morbidity and mortality worldwide. Corticosteroids have been used in sepsis management, but their efficacy and safety remain debated. This meta-analysis aims to evaluate the effectiveness of corticosteroids in sepsis management. Methods: A comprehensive search of PubMed, Embase, and Cochrane Library was conducted to identify randomized controlled trials (RCTs) published from 2018 to 2024 evaluating corticosteroid use in sepsis. The primary outcome was mortality. Secondary outcomes included length of hospital stay, duration of mechanical ventilation, and adverse events. Data were pooled using a random-effects model, and heterogeneity was assessed using the I² statistic. Results: Twenty-one RCTs (n=12,350 patients) were included. Corticosteroid therapy was associated with a significant reduction in mortality (risk ratio [RR] 0.87, 95% confidence interval [CI] 0.79-0.96, p=0.004). There was also a significant reduction in the length of hospital stay (mean difference [MD] -1.5 days, 95% CI -2.3 to -0.7, p<0.001) and duration of mechanical ventilation (MD -1.2 days, 95% CI -1.9 to -0.5, p<0.001). No significant increase in adverse events was observed. Conclusion: This meta-analysis suggests that corticosteroid therapy is associated with a significant reduction in mortality, length of hospital stay, and duration of mechanical ventilation in patients with sepsis. The benefits appear to outweigh the risks. Corticosteroids should be considered as part of the standard of care in sepsis management.
Co-Authors Ahmad, Armen Armen Ahmad Fadrian, Fadrian Putri, Vidola Yasena