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Fadrian, Fadrian
Department Of Internal Medicine, Faculty Of Medicine, Universitas Andalas/Dr. M. Djamil General Hospital, Padang, Indonesia
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Profil Tingkat Keparahan Retinopati Diabetik Dengan Atau Tanpa Hipertensi pada di RSUP Dr. M. Djamil Padang Putri Nirmala Dewi; Fadrian Fadrian; Havriza Vitresia
Jurnal Kesehatan Andalas Vol 8, No 2 (2019): Online Juni 2019
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v8i2.993

Abstract

Retinopati diabetik merupakan komplikasi mikrovaskular dari Diabetes Melitus (DM) berupa mikroangiopati progresif yang ditandai oleh kerusakan mikrovaskular pada retina. Retinopati diabetik menempati urutan ke-4 sebagai penyebab kebutaan secara global setelah katarak, glukoma, dan degenerasi makula. Terdapat berbagai faktor yang memengaruhi derajat keparahan retinopati diabetik seperti hiperglikemia, lama durasi DM, dan hipertensi. Tujuan penelitian ini adalah mengetahui profil tingkat keparahan retinopati diabetik dengan atau tanpa hipertensi pada pasien diabetes melitus di RSUP Dr. M. Djamil Padang. Jenis penelitian ini adalah deskriptif observasional retrospektif  dengan menggunakan data sekunder, yaitu rekam medik pasien retinopati diabetik di RSUP Dr. M. Djamil Padang periode Januari-Desember 2016. Data diolah menggunakan microsoft excel dan analisis data disajikan melalui analisis univariat. Populasi untuk penderita diabetes melitus sebanyak 1500 orang dengan penderita retinopati diabetik sebanyak 187 orang (12,5%) dan yang memenuhi kriteria inklusi sebanyak 162 orang. Hasil penelitian berdasarkan karakteristik penderita menurut usia terbanyak pada usia 45-65 tahun yaitu 129 orang (79,6%), menurut jenis kelamin lebih banyak pada laki-laki yaitu 87 orang (53,7%), menurut durasi menderita DM lebih banyak pada penderita >5 tahun sebesar 110 orang (68%), menurut ada tidaknya dislipdemia lebih banyak pada penderita dengan dislipdemia sebanyak 116 orang (71,7%). Profil tingkat keparahan retinopati diabetik terbanyak ada pada pasien dengan hipertensi pada stadium retinopatidiabetik proliferative sebanyak 56 orang (69,6%).
TERAPI ANTIVIRAL PADA SIROSIS HATI DEKOMPENSATA TERKAIT INFEKSI VIRUS HEPATITIS B Fadrian Fadrian
Majalah Kedokteran Andalas Vol 39, No 1 (2016): Published in April 2016
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (320.199 KB) | DOI: 10.22338/mka.v39.i1.p35-41.2016

Abstract

Hepatitis B masih merupakan masalah kesehatan global. Diperkirakan sekitar 2 miliar penduduk dunia pernah terpapar virus hepatitis B (VHB) dan lebih dari 350 juta diantaranya menjadi kronik. Sirosis hati, gagal hati, dan karsinoma hati dapat terjadi pada 15-40% penderita dengan infeksi virus hepatitis B kronik. Pada saat ini sekitar 1 juta kematian per tahun akibat penyakit hati berhubungan dengan VHB. Terapi antiviral pada sirosis hati dekompensata terkait VHB merupakan suatu tantangan dalam pengobatan. Tujuan terapi pada pasien sirosis hati dekompensata terkait VHB diantaranya penekanan replikasi virus, serokonversi HBeAg, pembalikan dekompensasi hati, dan pengurangan risiko kanker hati. Terapi antiviral diindikasikan pada semua pasien sirosis hati dekompensata jika DNA VHB terdeteksi, terlepas dari kadar ALT atau status HBeAg. Terapi antiviral pilihan adalah nucleosida/tida analog, seperti lamivudine, telbivudine, adefovir dipifoxil, tenofovir, entecavir. Lama pengobatan biasanya seumur hidup, dan penghentian terapi dipertimbangkan apabila terdapat risiko reaktivasi virus, perburukan dekompensasi hati, dan regresi histologis.
Antibiotics Used in Leptospirosis: A Narrative Literature Review Amelia F. Dewi; Armen Ahmad; Fadrian
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 12 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i12.628

Abstract

Leptospirosis is an acute infectious disease that affects both humans and animals (zoonosis). This disease is caused by the Leptospira species, a bacterium with 250 serovar variations which thus detecting its cases is prominently challenging. In Indonesia, Leptospirosis is regarded as an iceberg phenomenon since such a challenge prevents this disease from being diagnosed in clinical practice, despite study data indicating that a significant percentage of reservoir rats in Indonesia are positive for Leptospira bacteria. As such, this disease has a high mortality of rats due to therapeutic delays. The usage of antibiotics is consequently considered an optimal therapy for leptospirosis. Antibiotics are chosen based on the clinical severity of the disease and should be administered as prophylaxis in high-risk groups in order to lower morbidity and mortality.
Characteristics of Adult Sepsis Patients Admitted to Department of Internal Medicine, Dr. M. Djamil General Hospital, Padang, Indonesia Elvia Fataya; Fadrian; Mustafa Noer; Dwitya Elvira; Yuliarni Syafrita; Netti Suharti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 3 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i3.791

Abstract

Background: Sepsis is a life-threatening organ dysfunction resulting from a dysregulated host response to infection. Septic shock is the most dangerous complication of sepsis, characterized by abnormalities in the circulatory and metabolic systems. This study aimed to determine the characteristics of adult sepsis patients admitted to the department of internal medicine of Dr. M. Djamil General Hospital, Padang, Indonesia. Methods: This research was a descriptive study and used secondary data from medical records. Samples in this study were medical record data from the medical record installation of Dr. M. Djamil General Hospital, Padang, Indonesia. The inclusion criteria were adult patients aged more than 18 years old, diagnosed with sepsis, and hospitalized in the department of internal medicine for the period of January 2020 to December 2021. Results: Most of the sepsis patients were mostly aged more than 60 years old (51.7%), female (57.2%), and had normal BMI scores (59.3%). The infections mainly originated from the lungs (80%), the most common comorbid disease was chronic kidney disease (26.4%), the most frequent causing microorganism was Escherichia coli (15.9%), the frequent degree of severity was a septic shock (60%), and cefepime was used as the initial empirical antibiotic (44.8%). Conclusion: Most sepsis patients were adults aged more than 60 years old and females, with the focus on infection originating from the lungs, degree of severity in the form of septic shock, and the most used initial empirical antibiotic, namely cefepime.
Diagnosis and Management of Paraquat Intoxication Lydia Sarah Shabrina; Armen Ahmad; Fadrian Fadrian
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 8 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i8.848

Abstract

Paraquat poisoning is a clinical toxicological emergency due to the active ingredient of this type of herbicide, gramoxone, with a high mortality rate due to high toxicity, and no antidote has yet been found. Paraquat intoxication can cause multi-organ failure if ingested accidentally or spontaneously because paraquat quickly produces ROS (reactive oxygen species), which causes cell damage through lipid peroxidation, NF-kB activation, mitochondrial damage, and apoptosis in many organs. This results in rapid nephrotoxic and hepatotoxic as well as pulmonary fibrosis. Clinical manifestations depend on the level of paraquat ingested, which can be in the form of local toxicological and systemic toxicological effects. Laboratory tests for diagnosing paraquat toxicity can be used for toxicological analysis of plasma and urine. Management of paraquat intoxication is primarily to remove paraquat from the gastrointestinal tract (prevent absorption) by using activated charcoal, changing the toxicokinetics of the herbicide (increasing serum paraquat elimination) by hemoperfusion and hemodialysis, as well as modifying its toxicodynamics with anti-inflammatory drugs such as immunosuppressants (corticosteroids and cyclophosphamide) and antioxidants (N -acetylcysteine and vitamin C).
Hubungan Indeks Massa Tubuh dengan Kadar Glukosa Darah Puasa dan Tekanan Darah Pada Tenaga Kependidikan Fakultas Kedokteran Universitas Andalas Hidayatul Hasnah; Dwi Yulia; Desmawati desmawati; fadrian fadrian; yustini alioes; dessy arisanty
Majalah Kedokteran Andalas Vol 46, No 10 (2024): Supplementary April 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i10.p1532-1544.2024

Abstract

Tujuan : mengetahui hubungan indeks massa tubuh dengan kadar glukosa darah puasa dan tekanan darah pada tenaga kependidikan Fakultas Kedokteran Universitas Andalas. Metode : Jenis penelitian ini merupakan penelitian analitik dengan desain penelitian cross-sectional dengan subjek penelitian sebanyak 37 orang yang dilaksanakan di Fakultas Kedokteran Universitas Andalas pada tanggal 08 September 2021. Metode pengambilan sampel ini dengan total sampling, analisis data hubungan indeks massa tubuh dengan kadar glukosa darah puasa dan tekanan darah menggunakan uji korelasi Spearman. Hasil: Nilai median indeks massa tubuh sebesar 24,22 Kg/, nilai rerata 24,94 Kg/, nilai minimum sebesar 16,23 Kg/ dan nilai maksimum 40,15 Kg/. Nilai median kadar glukosa darah puasa 127 mg/dL, nilai rerata 143,65 mg/dL, nilai minimum sebesar 93 mg/dL dan nilai maksimum 399 mg/dL. Nilai median dari tekanan darah 126 mmHg,nilai rerata 128,7 mmHg,  nilai minimum 94 mmHg, dan nilai maksimum 213 mmHg. Tidak terdapat korelasi bermakna antara indeks massa tubuh dengan kadar glukosa darah puasa (p=0,203) ataupun pada indeks massa tubuh dengan tekanan darah (p= 0,097) pada subjek penelitian. Kesimpulan: tidak terdapat korelasi bermakna antara indeks massa tubuh dengan kadar glukosa darah puasa dan antara indeks massa tubuh dengan tekanan darah pada tenaga kependidikan pada Fakultas Kedokteran Universitas Andalas.  
Successful Management of Panuveitis and Associated Complications in a Patient with Clinical Stage III HIV: A Case Report Putra, Ikhsan Amanda; Fadrian; Rohayat Bilmahdi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 12 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i12.1144

Abstract

Background: Human immunodeficiency virus (HIV) infection can lead to a myriad of ocular complications, including panuveitis, an inflammatory condition affecting the entire uvea and surrounding structures. The management of panuveitis in HIV patients is complex, often requiring a multidisciplinary approach to address both the underlying immunodeficiency and the ocular inflammation. Case presentation: We present the case of a 37-year-old male patient with clinical stage III HIV who presented with panuveitis in the right eye (OD) secondary to herpes zoster ophthalmicus (HZO). The patient also had post-herpetic neuralgia, oral candidiasis, and malnutrition. He reported a history of unprotected sexual encounters with multiple partners. The patient's CD4 count was critically low at 15 cells/µL, indicating severe immunosuppression. He was initiated on antiretroviral therapy (ART), prophylactic medications to prevent opportunistic infections, and pain management for post-herpetic neuralgia. Conclusion: This case highlights the challenges in managing panuveitis and associated complications in patients with advanced HIV infection. Early diagnosis, prompt initiation of ART, and a multidisciplinary approach are crucial for successful management and improving patient outcomes.
Nilai Diagnostik Italian Score untuk Memprediksi Infeksi Bakteri Extended Spectrum Beta-Lactamase (ESBL) pada Pasien Sepsis di RSUP Dr. M. Djamil Padang Fadrian, Fadrian; Ahmad, Armen; Khairat, Khairat
Jurnal Penyakit Dalam Indonesia
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction. Infections caused by Extended-Spectrum Beta-Lactamase (ESBL) bacteria, especially in septic patients, require adequate management. Giving definitive antibiotics according to culture results takes a long time. Therefore, a clinical scoring system is needed to predict ESBL bacterial infection, one of which is the Italian score. Methods. This research used a cross-sectional design and was conducted in the inpatient room of RSUP Dr. M. Djamil Padang for 6 months. The samples in this study were septic patients who underwent culture examination at RSUP Dr. M. Djamil Padang who met the research inclusion and exclusion criteria. Sampling was carried out using consecutive sampling, and the total sample obtained was 34 samples. Selected samples will have an Italian score calculated, and specimens will be taken for clinical culture examination. Data analysis and processing will involve 2x2 tables and ROC curves. Results. Among a total of 34 participants with an equal distribution of male and female subjects (50% each), the average age was 59 years (standard deviation [SD] 14.15). Microbiological culture results revealed that 26 subjects (76.47%) were identified as positive for ESBL, while 8 subjects (23.53%) were classified as non-ESBL. Based on the Italian score, 22 patients were found to be ESBL-positive, and 12 were non-ESBL. The diagnostic performance of the Italian score yielded a sensitivity of 80.77%, specificity of 87.5%, positive predictive value (PPV) of 95.45%, and negative predictive value (NPV) of 58.33%. The accuracy of the Italian score in predicting ESBL bacterial infections among septic patients at RSUP Dr. M. Djamil Padang was demonstrated by an area under the curve (AUC) of 0.820 (95% confidence interval [CI] 0.75-1.00; p=0.002). Conclusion. The Italian score demonstrated significant performance as a tool in predicting the risk of ESBL bacterial infection.
HUBUNGAN DERAJAT KEPARAHAN COVID-19 DENGAN FUNGSI PARU PADA PENYINTAS COVID-19 DI FAKULTAS KEDOKTERAN UNIVERSITAS ANDALAS Prasetio, Ade; Anggraini, Fika Tri; Fadrian; Irawati, Lili; Anggrainy, Fenty; Alioes, Yustini
SINERGI : Jurnal Riset Ilmiah Vol. 2 No. 4 (2025): SINERGI : Jurnal Riset Ilmiah, April 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v2i4.1102

Abstract

COVID-19 telah menginfeksi banyak orang di seluruh dunia selama beberapa tahun terakhir. Virus ini terutama menargetkan sistem pernapasan dan membuat para penyintasnya berisiko mengalami efek jangka panjang setelah sembuh. Penelitian ini bertujuan untuk menentukan hubungan antara tingkat keparahan klinis COVID-19 dengan fungsi paru-paru pada penyintasnya. Spirometer berbasis PC digunakan untuk memeriksa fungsi paru pada penyintas COVID-19 ringan hingga sedang di Fakultas Kedokteran Universitas Andalas. Mayoritas penyintas COVID-19 di Fakultas Kedokteran Universitas Andalas memiliki tingkat keparahan klinis ringan (86,5%). Parameter spirometri yang mengalami penurunan paling banyak adalah VEP1 (16,2%), dan mayoritas penyintas COVID-19 memiliki fungsi paru yang normal (89,2%). Fungsi paru pada penyintas COVID-19 memiliki hubungan yang signifikan dengan keparahan klinis, yang dibuktikan dengan nilai p sebesar 0,005 (p < 0,05) pada uji Fisher exact. Terdapat hubungan antara tingkat keparahan klinis riwayat COVID-19 dengan fungsi paru pada penyintas, sehingga perlu dilakukan tindak lanjut pada pasien COVID-19 setelah dinyatakan sembuh dan diperlukan penatalaksanaan lebih lanjut pada pasien yang mengalami penurunan fungsi paru
In-hospital mortality and its determinant factors among patients with sepsis Fadrian, Fadrian; Decroli, Eva; Ahmad, Armen; Kam, Alexander; Muharramah, Disa Hijratul; Pradana, Genta; Putri, Vidola Yasena
Universa Medicina Vol. 44 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.3-15

Abstract

BACKGROUNDSepsis is a heterogeneous syndrome characterized by a variety of clinical features. Multiple studies have identified sepsis as the leading cause of death in hospitalized patients. A comprehensive report on the incidence, clinical characteristics, and predictors of sepsis is important. This study aimed to determine the relative importance of predictors of in-hospital mortality in sepsis. METHODSA retrospective cohort study at Dr. M. Djamil Central General Hospital focused on sepsis patients. A total of 200 participants, aged 18 and older, were included based on specific criteria and recruited through consecutive sampling. Data was gathered from medical records and laboratory results to identify factors influencing mortality in sepsis patients. These factors were classified into sociodemographic, intrinsic, and extrinsic categories. Statistical analysis utilized simple and multiple logistic regression. A p-value of less than 0.05 indicated statistical significance for predicting in-hospital mortality in sepsis. RESULTSThe sepsis patient mortality rate was 69.50%. Hospital-acquired pneumonia (HAP) emerged as the most common infectious diagnosis, impacting 47.50% of the patients. Type 2 diabetes mellitus (Type 2 DM) was identified as the most frequent comorbidity, present in 36.50% of cases. Multivariate analysis indicated that HAP (adjusted odds ratio [aOR] 2.32; 95% confidence interval [CI] 1.19–4.49; p=0.013) and hyperlactatemia (aOR 2.11; 95% CI 1.06–4.18; p=0.032) significantly increased the risk of mortality in sepsis patients. CONCLUSIONHospital-acquired pneumonia was the primary predictor of mortality in sepsis patients. Timely prediction and evaluation of sepsis outcomes are essential for developing strategies to reduce mortality rates.
Co-Authors Abdiana Adrial Adrial, Adrial Ahmad, Armen Amel Yanis Amelia F. Dewi Anggrainy, Fenty Arina Widya Murni Armen Ahmad Armen Ahmad Armen Ahmad Asir, Taufik Rizkian Astiena, Adila Kasni Bantar, Kevin Daan Khambri Desmawati Desmawati Desmawati Desmawati Dessy Arisanty Dwi Yulia Dwitya Elvira, Dwitya Dzulkifli, Dzulkifli Elvia Fataya Eva Decroli Fika Tri Anggraini Firdawati, Firdawati Genta Pradana, Genta Hardisman Harun Harnavi Harvindra, Astrid Hasmiwati Hasnah Hasnah Hasnah, Hidayatul Hermalina Sherli Utami Ida Rahmah Burhan Ikhsan Amanda Putra, Ikhsan Amanda Kam, Alexander Khairat, Khairat Lili Irawati Lydia Sarah Shabrina Masnadi, Nice Rachmawati Muhammad Hidayat Muharramah, Disa Hijratul Mustafa Noer Netti Suharti Oktalina, Dyanti Prasetio, Ade Priscilla, Hilary Putri Nirmala Dewi Putri, Vidola Yasena Putri, Viona Salsabila RAVEINAL RAVEINAL Rifa, Farras Zahra Rima Semiarty Rini Gusya Liza, Rini Gusya Rita Hamdani Rizki Amelia Rohayat Bilmahdi Rose Dinda Martini Rosfita Rasyid Roza Mulyana Rudy Afriant Saptino Miro, Saptino Selfi Renita Rusjdi Vitresia, Havriza Vivi Triana Wahyudi, Adefri Yugo Berri Putra Rio Yulia, Dwi Yuliarni Syafrita Yuniar Lestari Yustini Alioes Zaki Mahmudi Dasril