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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Pengabdian Masyarakat: Humanity and Medicine
Mega, Pratia
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Penyuluhan mengenai pencegahan dan deteksi dini kanker pada masyarakat Kota Prabumulih Rusminan, Suly Auline; Ulfa, Maria; Mega, Pratia; Fitria, Zahra; Sandria, Sandria
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 4 No 3 (2023): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V4I3.104

Abstract

Tumors or neoplasms are abnormal solid lesions that form due to improper cell growth, and cancer is a malignant tumor. Cancer has a high potential to damage surrounding organ tissue and metastasize to other organs. Risk factors for any cancer are free radicals, secondary lifestyle, lack of healthy food, and exposure to radiation. Cancer has high morbidity and mortality. And death due to late detection, and the lack of knowledge of most people about this disease, for example, early manifestations, what to do when finding a lump on the body, tests that can be done and early detection of cancer, and others, could be the main reasons. The education is aimed at the general public to provide an overview of organ health and efforts to prevent cancer with examination and safety procedures in the era of the COVID-19 pandemic. The implementation of this outreach is able to increase public knowledge about the importance of early cancer screening. Apart from that, educating the public about cancer and early detection can increase public knowledge about cancer and self-examination for early detection procedures.
THE ROLE OF BRAF V600E IN THE DEVELOPMENT OF THYROID CANCER PHENOTYPE: A SYSTEMATIC REVIEW Mega, Pratia; Aspitriani; Edi Poedjo Purnamawati, Ika Kartika; Krisna Murti
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 1 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i1.502

Abstract

BRAF V600E mutation in thyroid cancer is of major concern because it is associated with increased tumor aggressiveness through the MAPK pathway activation that affects phenotypic characteristics such as morphology and tissue invasion patterns. The results of studies on the effects of this mutation often vary and are influenced by differences in study design and detection methods. This systematic review aims to clarify the relationship between BRAF V600E and phenotypic characteristics of PTC, as well as identify its clinical implications. This study method was a systematic literature review using the PRISMA method, and there were 8418 journals. After exclusion, 16 articles were found that met the research objectives. Based on the results, it was found that there was a relationship between BRAF V600E and thyroid cancer phenotypes such as female gender, older age at diagnosis, larger tumor size, histological subtypes, especially tall cell, higher nuclear score, capsule, extrathyroid, vascular, nerve invasion, lymph node metastasis, higher clinical stage, recurrence, and lower survival. However, there are other inconsistent studies regarding the association of BRAF V600E with these phenotype characteristics. BRAF V600E mutation significantly affects the phenotypic characteristics of thyroid cancer and is associated with several aggressive characteristics.
Co-Authors Aspitriani Edi Poedjo Purnamawati, Ika Kartika Fitria, Zahra Krisna Murti Maria Ulfa Rusminan, Suly Auline Sandria, Sandria