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All Journal Majalah Patologi Indonesia Jurnal Pengabdian Masyarakat: Humanity and Medicine
Rusminan, Suly Auline
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Penyuluhan mengenai pencegahan dan deteksi dini kanker pada masyarakat Kota Prabumulih Rusminan, Suly Auline; Ulfa, Maria; Mega, Pratia; Fitria, Zahra; Sandria, Sandria
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 4 No 3 (2023): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V4I3.104

Abstract

Tumors or neoplasms are abnormal solid lesions that form due to improper cell growth, and cancer is a malignant tumor. Cancer has a high potential to damage surrounding organ tissue and metastasize to other organs. Risk factors for any cancer are free radicals, secondary lifestyle, lack of healthy food, and exposure to radiation. Cancer has high morbidity and mortality. And death due to late detection, and the lack of knowledge of most people about this disease, for example, early manifestations, what to do when finding a lump on the body, tests that can be done and early detection of cancer, and others, could be the main reasons. The education is aimed at the general public to provide an overview of organ health and efforts to prevent cancer with examination and safety procedures in the era of the COVID-19 pandemic. The implementation of this outreach is able to increase public knowledge about the importance of early cancer screening. Apart from that, educating the public about cancer and early detection can increase public knowledge about cancer and self-examination for early detection procedures.
Relationship between Mismatch Repair (MMR) Status and Chemotherapy Response in Colorectal Carcinoma Desmeradd, Soraya Sagita; Rusminan, Suly Auline; Kartika, Ika; Bahar, Erial
Majalah Patologi Indonesia Vol. 34 No. 3 (2025): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i3.710

Abstract

Background Colorectal carcinoma has several pathways that play a role in normal colonic mucosa development into carcinoma, one of microsatellite instability (MSI) pathway. This pathway results from a deficiency in one of the MMR proteins that normally repair genome damage, leading to microsatellite instability high (MSI-H) and excessive mutations. MSI-H is closely associated with Lynch syndrome and often experiences resistance to chemotherapy treatment, one of which is 5-fluorouracil (5-FU), so it is necessary to conduct initial screening in colorectal carcinoma to assess MMR status on patient with Lynch syndrome . This study aims to see relationship between MMR status and chemotherapy response in colorectal carcinoma. Methods This study is cross sectional study using 30 archival block and slaid samples of all colorectal carcinoma cases from hemicolectomy and biopsy results that have been histopathologically diagnosed in Anatomic Pathology Section of Faculty of Medicine Unsri/RSMH Palembang January 2017-December 2021. Each sample was immunohistochemically stained using four antibodies namely anti-MLH1, anti-MSH2, anti-MSH6 and anti-PMS2 (ventana). Interpretation was qualitative by assessing cell positivity. Categorized into intact and missing with cut-off point value of >10% positive declared intact. MMR deficiency was considered if there was loss of cell positivity, at least one MMR CPI marker and MMR proficiency if all MMR CPI were intact. Analysis of relationship between MMR status and chemotherapy response was performed using Fisher's exact test. Results Fisher's exact test showed an association between MMR status and chemotherapy response. The results were significantly significant with p-value of 0.045 where MMR deficiency status had a 6 times chance of not responding to chemotherapy compared to MMR proficiency. There was no association between MMR status and age, gender, histopathological subtype and tumor location with p-values of 0.139, 1.000, 0.657 and 0.174 respectively. Conclusion There was a significant association between MMR status and chemotherapy response.
Co-Authors Desmeradd, Soraya Sagita Erial Bahar, Erial Fitria, Zahra Ika Kartika Maria Ulfa Mega, Pratia Sandria, Sandria