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All Journal Indonesian Journal of Cancer Ahmad Dahlan Medical Journal
Perdana Putri, Rachma Greta
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Major Microbiota Profile of Breast Cancer From Faecal Specimen and Cancerous Breast Tissue: A Comprehensive Systematic Review Annisa, Annisa; Perdana Putri, Rachma Greta; Solikhah, Solikhah
Indonesian Journal of Cancer Vol 17, No 4 (2023): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i4.1030

Abstract

Background: The microbiota population in breast cancer tissue is known to have a crucial role in the tumor microenvironment supporting developmental ability. Despite a heterogeneous profile, the relationship between microbiota and breast cancer is still not fully understood. Therefore, this study aimed to explain the major microbiota profile associated with breast cancer and explore potential biological connections Methods: Following the PRISMA guidelines, the literature review investigated the diverse composition of microbiota profiles in breast cancer patients compared to those in normal conditions. Utilizing the PICO framework, a comprehensive search was conducted on the Pubmed and Google Scholar databases. The searches were restricted to open-access articles from the last 5 years. Additionally, critical appraisals are conducted for quality assessment. Results: A total of 145 articles were identified using the relevant keywords, out of which 17 successfully passed filtering and screening for inclusion in the review. Major microbiota observed in breast cancer patients included firmicutes, proteobacteria, actinobacteria, and bacteroidetes. The microbiota profile was influenced by factors such as cancer subtype, menopausal history, and tumor severity. These microorganisms play a role in the inflammatory response to their metabolite products and modulate hormonal changes, potentially enhancing tumor survival. Conclusions: Generalizing the expression of microbiota profile both in the gut or its tissue might be challenging due to its multifactorial nature, dependent on patient characteristics such as age, menopausal status, BMI, tumor grade, and subtype. The study suggests that the major microbiota that shows increased prevalence in breast cancer include firmicutes, proteobacteria, actinobacteria, bacteroidetes, and blautia, each playing a distinct role in the developmental process. 
Management of Sodium Imbalance Purwanto, Barkah Djaka; Perdana Putri, Rachma Greta
Ahmad Dahlan Medical Journal Vol. 5 No. 1 (2024): May 2024
Publisher : Universitas Ahmad Dahlan

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Abstract

Sodium imbalance consists of hyponatremia and hypernatremia. Acute and severe hyponatremia and hypernatremia are life-threatening conditions. Rapid and slow correction should be considered for optimal outcomes, as aggressive management is often associated with the danger of demyelination and cerebral edema. This review aims to determine the safe management of sodium imbalance so that it is hoped that in overcoming critical conditions it does not transfer to other critical conditions that are equally fatal. The data search strategy uses the PubMed and Google Scholar databases between 2010 and 2022 with free full text that can be downloaded. The findings emphasize that acute and severe hyponatremia and hypernatremia are often life-threatening conditions. Management of these conditions requires caution, as aggressive correction in hyponatremia can result in osmotic demyelination, while hypernatremia can lead to cerebral edema. Despite theoretical risks, the study found no significant difference in 30-day mortality, seizures, cerebral edema, or decreased consciousness between fast and slow correction methods. The conclusion underscores the importance of tailored and cautious management strategies to mitigate the risks associated with sodium imbalance corrections.
The Effect of Education using Comics on the Knowledge of Earthquake Mitigation of 4th Grade Students at Al-Azhar 16 Islamic Elementary School Cilacap Reza, Anggit; Wijaya, Oktomi; Qomariyah, Nurul; Hutomo, Muhammad Agita; Khoiru Nisa, Afifah; Ulfa, MH Muflihatul; Perdana Putri, Rachma Greta
Ahmad Dahlan Medical Journal Vol. 5 No. 1 (2024): May 2024
Publisher : Universitas Ahmad Dahlan

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Abstract

Indonesia is an archipelagic country situated on the Ring of Fire, which frequently experiences earthquakes. Cilacap Regency is ranked 456th nationally with a medium-risk classification in the Earthquake Disaster Risk Index for the year 2021. The impact of earthquakes depends on their type and magnitude, including on schools, with 52,902 schools located in earthquake-prone areas. During the 2018 NTB Earthquake, 1,235 schools experienced damage. Earthquakes can also occur while children are studying at school. Elementary schools are one of the foundations of the children's community. The group of elementary school children is a vulnerable group that needs protection and, at the same time, needs to enhance their knowledge of earthquake disaster mitigation. One enjoyable medium to educate elementary school children about earthquake disaster mitigation is through comics.To determine the influence of Education with Comic Media on the Knowledge of Earthquake Disaster Mitigation for 4th-grade students at SD Islam Al-Azhar 16 Cilacap, a research was conducted using a qualitative research method with a Pre Experimental design using the One Group Pretest-Posttest design. The sampling technique used in this study was total sampling, so all 78 members of the population were included as samples.Statistical analysis using the Wilcoxon signed-rank test showed a Z-value of -6.941 and a significance value (p-value) of 0.000, at α = 0.05. This means that there is a significant difference in the average knowledge between before and after providing Education with Comic Media for Earthquake Disaster Mitigation.
Co-Authors Annisa Annisa Hutomo, Muhammad Agita Khoiru Nisa, Afifah Nurul Qomariyah Oktomi Wijaya Purwanto, Barkah Djaka Reza, Anggit Solikhah Solikhah Ulfa, MH Muflihatul