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All Journal Journal of Food and Pharmaceutical Science Majalah Farmaseutik Journal of Food and Pharmaceutical Sciences
Kusumorini, Nindya
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience

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Optimization of Highly Porous Mannitol Preparation using Ammonium bicarbonate and Citric acid as Templating Agents with Spray Drying Technique Kusumorini, Nindya; Adhyatmika
Journal of Food and Pharmaceutical Sciences Vol 11, No 3 (2023): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.10062

Abstract

This study investigated the effect of ammonium bicarbonate and citric acid as templating agents using spray drying technique to improve the porosity of D-mannitol powder. It has been shown that textural properties, such as surface area and pore volume produced, are affected by the type and concentration of templating agents, inlet temperature, and outlet temperature of spray drying. The structure of mannitol powder produced changes considerably due to the change in its textural properties to particle powder with high porosity, surface area, and pore volume. The results show that the ratio of D-mannitol to ammonium bicarbonate 10:5 w/w% with water solvent temperature of 30 oC, spray drying inlet temperature of 120 oC, and spray drying outlet temperature of 70 oC, resulting in the highest porosity, surface area, and pore volume. The surface area of mannitol increased from 1.167 m2/g to 3.571 m2/g, followed by an increase in pore volume from 0.0022 cc/g to 0.012 cc/g and pore diameter from 75.33 Å to 115.2 Å. The scanning electron microscope (SEM) results are consistent with the surface area measurement results using the Surface Area Analyzer (SAA). The resulting spray-dried mannitol powder with a high specific surface area allows it to be used as an excipient in solid formulations of oral preparations.
Determination of Octyl Methoxycinnamate Levels On The Face Sunscreen Gel Using Uv-Vis Spectrophotometry Method Rochmiyanti, Hidayah; Haresmita, Perdana Priya; Syarifuddin, Alfian; Kusumorini, Nindya
Majalah Farmaseutik Vol 19, No 4 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i4.81911

Abstract

Sunlight has many benefits for the health of the body, but excessive and long-term exposure to sunlight can have an impact on skin damage, such as sunburn, photoaging (premature aging), and dull skin. Ultraviolet (UV) radiation is a major cause of skin cancer, so many sunscreen gels contain UV filters. Octyl methoxycinnamate is an example of an active UV filter agent. Octyl methoxycinnamate is a cinnamic compound that absorbs light wavelengths 280 nm–320 nm (UVB). This study aims to determine the octyl levels of methoxycinnamate in sunscreen gel preparations circulating in Magelang Regency and assess whether these preparations meet the predetermined safety limits. The analysis used in this research is qualitative and quantitative analysis. Qualitative study using thin layer chromatography (TLC) with silica gel F254 as stationary phase and mobile phase n-hexane : ethyl acetate (7.5 : 2.5) and then detected on UV light at 254 nm. Quantitative analysis using UV-Vis spectrophotometer at a maximum wavelength of 310.5 nm. The results of the qualitative analysis showed that the three samples X, Y and Z were positive contain octyl methoxycinnamate. The results of the TLC showed that samples X, Y, and Z produced purple stains and had the same Rf values between the samples and the standards. Octyl methoxycinnamate levels in sample X of 0.155%; Y 0.824%; and Z 1.954%. The results obtained by the relative standard deviation (RSD) of the sunscreen gel sample were X 0.015%; Y 0.048%; and Z 0.921%. It can be concluded that the three tested sunscreen gel samples are safe for use by the general public.
Development of glibenclamide validation method using UV-Spectrophotometry for solubility test in mesoporous mannitol Kusumorini, Nindya; Adhyatmika, Adhyatmika; Biruni, Sheria Itqan; Anugrahanti, Sukmarini
Majalah Farmaseutik Vol 19, No 3 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i3.90435

Abstract

This study was aimed to develop a validation method for glibenclamide in mesoporous mannitol using UV spectrophotometric method. This method was chosen because it is simple, sensitive, accurate, precise, reproducible and economical. The wavelength of glibenclamide (λ max) was obtained at 229 nm using ethanol and water in a ratio of 1:1. The linearity of glibenclamide was selected at a concentration of 5 - 17.5 µg/mL. Correlation coefficient (r) = 0.9998; intraday RSD < 1%; interday RSD < 2%, recovery 100 - 105%, LOD = 0.32 µg/mL and LOQ = 1.08 µg/mL, and has high sensitivity because the presence of mesoporous mannitol in the solution does not interfere with the reading process of glibenclamide. So it can be concluded that this method has good reproducibility based on the results of linearity, precision, and accuracy of glibenclamide and in accordance with ICH requirements, so this method can be used for routine analysis of glibenclamide compounds in mesoporous mannitol.
Optimization of Highly Porous Mannitol Preparation using Ammonium bicarbonate and Citric acid as Templating Agents with Spray Drying Technique Kusumorini, Nindya; Adhyatmika
Journal of Food and Pharmaceutical Sciences Vol 11, No 3 (2023): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.10062

Abstract

This study investigated the effect of ammonium bicarbonate and citric acid as templating agents using spray drying technique to improve the porosity of D-mannitol powder. It has been shown that textural properties, such as surface area and pore volume produced, are affected by the type and concentration of templating agents, inlet temperature, and outlet temperature of spray drying. The structure of mannitol powder produced changes considerably due to the change in its textural properties to particle powder with high porosity, surface area, and pore volume. The results show that the ratio of D-mannitol to ammonium bicarbonate 10:5 w/w% with water solvent temperature of 30 oC, spray drying inlet temperature of 120 oC, and spray drying outlet temperature of 70 oC, resulting in the highest porosity, surface area, and pore volume. The surface area of mannitol increased from 1.167 m2/g to 3.571 m2/g, followed by an increase in pore volume from 0.0022 cc/g to 0.012 cc/g and pore diameter from 75.33 Å to 115.2 Å. The scanning electron microscope (SEM) results are consistent with the surface area measurement results using the Surface Area Analyzer (SAA). The resulting spray-dried mannitol powder with a high specific surface area allows it to be used as an excipient in solid formulations of oral preparations.
Co-Authors Adhyatmika Adhyatmika, Adhyatmika Anugrahanti, Sukmarini Biruni, Sheria Itqan Perdana Priya Haresmita, Perdana Priya Rochmiyanti, Hidayah Syarifuddin, Alfian