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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Journal of Food and Pharmaceutical Science Journal of Food and Pharmaceutical Sciences
Adhyatmika
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Optimization of Highly Porous Mannitol Preparation using Ammonium bicarbonate and Citric acid as Templating Agents with Spray Drying Technique Kusumorini, Nindya; Adhyatmika
Journal of Food and Pharmaceutical Sciences Vol 11, No 3 (2023): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.10062

Abstract

This study investigated the effect of ammonium bicarbonate and citric acid as templating agents using spray drying technique to improve the porosity of D-mannitol powder. It has been shown that textural properties, such as surface area and pore volume produced, are affected by the type and concentration of templating agents, inlet temperature, and outlet temperature of spray drying. The structure of mannitol powder produced changes considerably due to the change in its textural properties to particle powder with high porosity, surface area, and pore volume. The results show that the ratio of D-mannitol to ammonium bicarbonate 10:5 w/w% with water solvent temperature of 30 oC, spray drying inlet temperature of 120 oC, and spray drying outlet temperature of 70 oC, resulting in the highest porosity, surface area, and pore volume. The surface area of mannitol increased from 1.167 m2/g to 3.571 m2/g, followed by an increase in pore volume from 0.0022 cc/g to 0.012 cc/g and pore diameter from 75.33 Å to 115.2 Å. The scanning electron microscope (SEM) results are consistent with the surface area measurement results using the Surface Area Analyzer (SAA). The resulting spray-dried mannitol powder with a high specific surface area allows it to be used as an excipient in solid formulations of oral preparations.
Optimization of Highly Porous Mannitol Preparation using Ammonium bicarbonate and Citric acid as Templating Agents with Spray Drying Technique Kusumorini, Nindya; Adhyatmika
Journal of Food and Pharmaceutical Sciences Vol 11, No 3 (2023): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.10062

Abstract

This study investigated the effect of ammonium bicarbonate and citric acid as templating agents using spray drying technique to improve the porosity of D-mannitol powder. It has been shown that textural properties, such as surface area and pore volume produced, are affected by the type and concentration of templating agents, inlet temperature, and outlet temperature of spray drying. The structure of mannitol powder produced changes considerably due to the change in its textural properties to particle powder with high porosity, surface area, and pore volume. The results show that the ratio of D-mannitol to ammonium bicarbonate 10:5 w/w% with water solvent temperature of 30 oC, spray drying inlet temperature of 120 oC, and spray drying outlet temperature of 70 oC, resulting in the highest porosity, surface area, and pore volume. The surface area of mannitol increased from 1.167 m2/g to 3.571 m2/g, followed by an increase in pore volume from 0.0022 cc/g to 0.012 cc/g and pore diameter from 75.33 Å to 115.2 Å. The scanning electron microscope (SEM) results are consistent with the surface area measurement results using the Surface Area Analyzer (SAA). The resulting spray-dried mannitol powder with a high specific surface area allows it to be used as an excipient in solid formulations of oral preparations.
Comparison of Thin Layer Hydration and Dispersion Method of Transfersome Formulation Containing Hyaluronic Acid and Glutathione as Antioxidant Dian Ermawati; Adhyatmika; Yuniarti, Nunung; Teuku Nanda Saifullah Sulaiman
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 11 No. 1 (2026)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v11i1.44450

Abstract

Glutathione is a tripeptide (L-ᵞ-glutamyl-L-cysteinyl-glycine) that serves as an antioxidant in the body and can be coupled with hyaluronic acid for anti-aging purposes. Glutathione, being hydrophilic, encounters challenges in penetrating the stratum corneum barrier to access the deeper epidermal layers; thus, a transfersome delivery mechanism is requisite. This study aimed to examine the synthesis of transfersome containing glutathione and hyaluronic acid using the thin layer hydration method and the dispersion method. The characteristics measured included organoleptic properties, particle size, zeta potential, polydispersity index (PDI), entrapment efficiency, and antioxidant activity assessed via the DPPH method. Particle size and PDI were found to be 124.5 ± 14.11 nm, 0.367± 0.07 for thin layer hydration method and 583.03 ± 32.41 nm, 0.595 ± 0.03 for dispersion method respectively. Entrapment efficiency showed that the thin layer hydration method was greater at 35.65% ± 3.54 compared to the dispersion method at 19.10 % ± 1.13. Antioxidant activity showed the inhibition in thin layer hydration and dispersion method was 42.48% ± 0.84 and 41.23% ± 2.09 respectively. In conclusion, the thin layer hydration method gives more optimal results than the dispersion method.
Co-Authors Dian Ermawati Kusumorini, Nindya Nunung Yuniarti Teuku Nanda Saifullah Sulaiman