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All Journal Majalah Obat Tradisional Acta Pharmaciae Indonesia : Acta Pharm Indo Majalah Farmaseutik Chemistry Indonesian Journal of Chemical Research JFL : Jurnal Farmasi Lampung Jurnal Farmasi Higea Jurnal Mandala Pharmacon Indonesia Fullerene Journal of Chemistry Jurnal Ilmu Kesehatan Jurnal Medika Cendikia (e-Journal) Jurnal Sains Kesehatan Journal of Fundamental and Applied Pharmaceutical Science Sasambo Journal of Pharmacy Mandala of Health : A Scientific Journal Journal of Community Empowerment Jurnal Farmasi Galenika Analit: Analytical And Environmental Chemistry
Perdana Priya Haresmita, Perdana Priya
Faculty of Pharmacy, Universitas Gadjah Mada
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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PENENTUAN AKTIVITAS ANTIOKSIDAN Garcinia dulcis (Roxb.) Kurz, Blumeamollis (D.Don)Merr., Siegesbeckia orientalis L., DAN Salvia riparia H.B.K YANG DIKOLEKSI DARI TAMAN NASIONAL GUNUNG MERAPI DENGAN METODE DPPH(2,2-DIFENIL-1-PIKRIL-HIDRAZIL) SERTA PROFIL Santosa, Djoko; Haresmita, Perdana Priya
Majalah Obat Tradisional Vol 20, No 1 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1008.539 KB) | DOI: 10.14499/mot-TradMedJ20iss1pp%p

Abstract

Penelitian ini bertujuan untuk menentukan aktivitas antioksidan ekstrak wasbenzen dan metanolik empat jenis tumbuhan, yaitu Garcinia dulcis (Roxb.)Kurz, Blumea mollis (D.Don) Merr., Siegesbeckia orientalis L.,dan Salvia riparia H.B.K hasil koleksi dari TNGM berdasarkan metode penangkapan radikal bebas dengan DPPH dan mengetahui profil kromatografi lapis tipisnya. Ekstrak dibuat dengan proses maserasi bertingkat dengan penyari wasbenzen dan metanol, uji aktivitas antioksidan dengan metode DPPH serta analisis kualitatif dengan kromatografi lapis tipis (KLT) untuk tumbuhan dengan aktivitas antioksidan tertinggi. Hasil penelitian menunjukkan bahwa diantara keempat ekstrak metanolik, ekstrak Garcinia dulcis (Roxb.) Kurz mempunyai aktivitas antioksidan tertinggi dengan nilai IC50 38,613µg/mL. Untuk ekstrak wasbenzen, ekstrak Garcinia dulcis (Roxb.) Kurz juga mempunyai aktivitas tertinggi dengan nilai IC50 139,381µg/mL. Analisis kualitatif ekstrak metanolik Garcinia dulcis (Roxb.) Kurz dengan kromatografi lapis tipis (KLT) menunjukkan bahwa ekstrak metanolik Garcinia dulcis (Roxb.) Kurz mengandung senyawa golongan fenol dan flavonoid.
Description of Mother’s Knowledge and Adherence to Use of Helminthic Drugs in Kuwaluhan Village, Magelang Regency, Central Java Amanda, Shalma Risqi; Haresmita, Perdana Priya; Wardani, Arief Kusuma; Hadi, Ismanurrahman
Jurnal Ilmu Kesehatan Vol 11 No 1 (2023): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30650/jik.v11i1.3626

Abstract

Worm infection has become public health issue with the highest prevalence in children under the age of five and elementary school-aged children. The children have difficulty maintaining the hygienist, especially when they are playing. This study aims to describe the level of knowledge and mothers’ adherence to the use of helminthic drugs in Kuwaluhan Village, Magelang Regency. This research used a descriptive study with both a survey method and a cross-sectional approach. The purposive sampling technique was used, while the questionnaire was distributed to mothers with children under the age of five and elementary school-age children in Kuwaluhan Village RW 2, Magelang Regency, in December 2022. The results showed that the level of knowledge of mothers in Kuwaluhan Village RW 2, Magelang Regency, regarding the use of helminthic drugs out of a total of 74 mothers indicated that 33 respondents (44.59%) had good knowledge, 29 respondents (39.19%) had sufficient knowledge, and as many as 12 respondents (16.22%) had less knowledge. Meanwhile, at the adherence level, respondents were categorized as having high adherence by 1 respondent (1.35%), medium adherence by 73 respondents (98.65%), and low adherence by 0 respondents (0%). Based on these results, most of the mothers in Kuwaluhan RW 2, Magelang Regency have good knowledge and have a medium level of adherence to using helminthic drugs for children.
QUALITATIVE AND QUANTITATIVE ANALYSIS OF MEDICINAL CHEMICALS OF “ JAMU REMATIK DAN PEGAL LINU “ IN MAGELANG REGION Haresmita, Perdana Priya; Wardani, Arief Kusuma; Pradani, Missya Putri Kurnia; Permatasari, Lina
Jurnal Ilmu Kesehatan Vol 11 No 2 (2023): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30650/jik.v11i2.3829

Abstract

Jamu for rheumatism and "pegal linu" are two of the most commonly used traditional medicine products in the community, so it is a type of traditional medicine preparation that is prone to the addition of medicinal chemicals. Any type of medicinal chemical should not be added to herbal preparations. The purpose of this study was to determine is there any medicinal chemicals in traditional medicine samples for "pegal linu" and rheumatism in the Magelang area. The total number of samples used is nine. Thin layer chromatography was used to analyze medicinal chemicals in traditional medicine, and preliminary organoleptic test was performed. The next step is a quantitative analysis using the UV-Visible spectrophotometric method. Prednisone, mefenamic acid, and ibuprofen were used as standards. The stationary phase was silica gel 60 F254, and the mobile phase was ethyl acetate: chloroform (4:1) for the prednisone standard, chloroform:methanol (9:1) for the mefenamic acid standard, and chloroform:ethanol (8:1) for the ibuprofen standard. Thin layer chromatography analysis showed that three of the nine traditional medicine samples tested positive for prednisone, but none contained mefenamic acid or ibuprofen. Herbs A, D, and E contained prednisone in their samples. Prednisone concentrations in the three samples were 0,252%; 0.754%, and 2,005%, respectively.
IDENTIFIKASI BAHAN KIMIA OBAT PADA JAMU PEGAL LINU DI WILAYAH KULON PROGO SECARA KROMATOGRAFI LAPIS TIPIS Nadia, Mayla Eka; Haresmita, Perdana Priya
Jurnal Farmasi Higea Vol 16, No 2 (2024)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52689/higea.v16i2.569

Abstract

Jamu telah menjadi bagian tak terpisahkan dari budaya dan kekayaan Indonesia selama berabad-abad, penggunaan jamu di Kulon Progo tetap mengikuti beberapa prinsip, di mana jamu tidak diperbolehkan mengandung bahan kimia obat (BKO). Hal ini dikarenakan kepercayaan bahwa jamu yang benar-benar alami dan terbuat dari bahan-bahan tradisional akan memberikan manfaat kesehatan yang lebih baik tanpa efek samping yang berbahaya. Sampel diambil dari 3 pasar di daerah Kulon Progo yaitu Pasar Jagalab, Pasar Bogo, dan Pasar Ndekso. Tujuan dari penelitian ini adalah mengidentifikasi kandungan bahan kimia obat pada jamu pegal linu di wilayah Kulonprogo sehingga dapat dijadikan sebagai acuan keamanan obat dan dapat dilakukan penelitian lebih lanjut. Penelitian ini menggunakan metode deskriptif yaitu metode penelitian dengan menggambarkan keadaan subjek atau objek dalam penelitian  berdasarkan fakta-fakta yang tampak atau apa adanya, dengan analisa kualitatif menggunakan metode Kromatografi Lapis Tipis (KLT). Fase diam yang digunakan pada saat penelitian ini adalah silika gel 254 dan fase gerak yang digunakan etil asetat: heksana (4:1), kloroform: etil asetat (4,5: 0,5), klotoform: etanol (4,5:0,5), dan etil asetat: kloroform (4:1). Hasil penelitian ini menunjukkan bahwa dari 4 sampel terdapat 4 sampel yang positif mengandung prednison dan parasetamol.  
Determination of Octyl Methoxycinnamate Levels On The Face Sunscreen Gel Using Uv-Vis Spectrophotometry Method Rochmiyanti, Hidayah; Haresmita, Perdana Priya; Syarifuddin, Alfian; Kusumorini, Nindya
Majalah Farmaseutik Vol 19, No 4 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i4.81911

Abstract

Sunlight has many benefits for the health of the body, but excessive and long-term exposure to sunlight can have an impact on skin damage, such as sunburn, photoaging (premature aging), and dull skin. Ultraviolet (UV) radiation is a major cause of skin cancer, so many sunscreen gels contain UV filters. Octyl methoxycinnamate is an example of an active UV filter agent. Octyl methoxycinnamate is a cinnamic compound that absorbs light wavelengths 280 nm–320 nm (UVB). This study aims to determine the octyl levels of methoxycinnamate in sunscreen gel preparations circulating in Magelang Regency and assess whether these preparations meet the predetermined safety limits. The analysis used in this research is qualitative and quantitative analysis. Qualitative study using thin layer chromatography (TLC) with silica gel F254 as stationary phase and mobile phase n-hexane : ethyl acetate (7.5 : 2.5) and then detected on UV light at 254 nm. Quantitative analysis using UV-Vis spectrophotometer at a maximum wavelength of 310.5 nm. The results of the qualitative analysis showed that the three samples X, Y and Z were positive contain octyl methoxycinnamate. The results of the TLC showed that samples X, Y, and Z produced purple stains and had the same Rf values between the samples and the standards. Octyl methoxycinnamate levels in sample X of 0.155%; Y 0.824%; and Z 1.954%. The results obtained by the relative standard deviation (RSD) of the sunscreen gel sample were X 0.015%; Y 0.048%; and Z 0.921%. It can be concluded that the three tested sunscreen gel samples are safe for use by the general public.
Comprehensive In silico Analysis of Antibacterial Compounds in n-Hexane Fraction from Jeruju Leaf (Acanthus ilicifolius) Wardani, Arief Kusuma; Haresmita, Perdana Priya; Alda, Mahkota; Vaira, Tischa
Indonesian Journal of Chemical Research Vol 11 No 3 (2024): Edition for January 2024
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2024.11-ari

Abstract

In an emergency, to identify the most promising Hesperidin, Kaempferol-3,4'-di-O-methyl ether (Ermanin); Myricetin-3-glucoside, Peonidine 3-(4’-arabinosylglucoside); Quercetin 3-(2G-rhamnosylrutinoside); and Rhamnetin 3-mannosyl-(1–2)-alloside as a lead compound from Jeruju to develop new drugs from flavonoid analog. The active compound's structure is derived from the PubChem database and improves the stability through ChemDraw v19. The Protein Data Bank website identified the protein macromolecule with PDB code 3VSL. Redocking was performed to ensure validation of 3VSL. The docking method was carried out using the IGEMDOCK software version v2.1. Also, the chimera-1.13.1 program is used to know the interaction profile. The web server pkCSM and Protox II online tool were used to determine the toxicity. 3,7,11,15-tetramethyl-2-hexadecen-1-ol is the juju leaf chemical with the most promise as an antibacterial and the one that shows the maximum binding affinity when taking into account toxicity.
Qualitative and Quantitative Analysis of Compounds in Kencur Extract Using TLC and UV-Vis Spectrophotometry Amarta, Fitri Dwi; Haresmita, Perdana Priya; Eltivitasari, Andita
Jurnal Medika Cendikia Vol 11 No 02 (2024): Jurnal Medika Cendikia
Publisher : Karsa Husada Health Institute Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmc.v11i02.252

Abstract

Kencur (Kaempferia galanga L.) is one of the plants in the Zingiberaceae family (gingers) that is often used by people in Asia, including Indonesia. Kencur is also widely used as a traditional medicine because it contains active compounds that are beneficial for treatment. This research aims to conduct a qualitative and quantitative analysis of secondary metabolites in Kencur extract samples. Qualitative analysis was conducted using thin layer chromatography with three variations of the mobile phase: Chloroform : Methanol (95:5), Chloroform : Methanol : Glacial Acetic Acid (94:5:1), Chloroform : n-Hexane : Methanol (1:1:0.1), and the stationary phase Silica Gel GF254. Meanwhile, the quantitative analysis was conducted using UV-Vis spectrophotometry at a wavelength of 429.5 nm. The research results show that Kencur contains compounds such as tannins, glycosides, and terpenoids. This research also identifies the presence of curcumin, which has antioxidant effects and other benefits. The results indicate that 2 out of 3 experiments showed positive results, with Kencur containing curcumin at levels of 0.4593% and 0.4393%. The methods used were qualitative methods through thin-layer chromatography and quantitative analysis of curcumin levels in the samples using UV-Vis spectrophotometry.
Analysis of sildenafil citrate in male stamina herbal medicines from the Magelang region, Central Java using thin-layer chromatography and UV spectrophotometry Saputra, Ilham Fahmi; Haresmita, Perdana Priya; Dianita, Puspita Septie; Kholifah, Eva
Acta Pharmaciae Indonesia Vol 12 No 1 (2024): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2024.12.1.11964

Abstract

Background: Male stamina herbal medicines are widely consumed in Indonesia, often believed to enhance sexual performance. However, the illegal addition of medicinal chemicals (BKOs) such as sildenafil citrate in traditional herbal products poses health risks. Objective: To identify and quantify sildenafil citrate in selected herbal medicine samples using thin-layer chromatography (TLC) and UV spectrophotometry. Method: Three samples of male stamina herbal medicine were purchased and subjected to organoleptic tests. Ethanol (96%) was used for extraction, followed by TLC analysis using two mobile phases (methanol: chloroform at 4:1 and 1:1 ratios). UV spectrophotometry was employed to determine the maximum absorbance wavelength and quantify sildenafil citrate. Results: TLC analysis revealed that two samples (K and L) contained sildenafil citrate, with Rf values consistent with the standard. UV spectrophotometry confirmed the presence of sildenafil citrate at a maximum wavelength of 292.5 nm. Sample K contained 0.96%, while sample L had 13.766% sildenafil citrate. Conclusion: The presence of sildenafil citrate in two samples violates Indonesian regulations prohibiting medicinal chemicals in herbal products, raising significant safety concerns.
Analisis kualitatif bahan kimia obat dalam jamu pegal linu di wilayah kabupaten Grobogan Azri, Anna Sa'dia; Haresmita, Perdana Priya
Sasambo Journal of Pharmacy Vol. 5 No. 2 (2024): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v5i2.341

Abstract

The use of traditional medicine in Indonesia, particularly jamu, remains very popular and an important part of the public health culture. According to the 2018 Riskesdas data, around 59.12% of the Indonesian population consumes jamu, and 95.6% of them recognize the health benefits obtained from it. Jamu, which is made from various types of plants, has been used for thousands of years to maintain health and treat various diseases. This study used Thin Layer Chromatography to identify Medicinal Chemicals (BKO) in jamu circulating in Grobogan Regency, Central Java. The purpose of this study was to analyze the content of medicinal chemicals in traditional herbal medicine. Six samples of jamu pegal linu were tested with Silica Gel 60 F254 stationary phase and different mobile phases for each standard. The results showed that all samples of jamu pegal linu tested did not contain the investigated BKOs, indicating product safety from this aspect.
Pengaruh Ekstraksi Bertingkat Terhadap Kadar Flavonoid Total Ekstrak Binahong (Anredera cordifolia (Ten) Steenis) Fitriyani, Nisa; Haresmita, Perdana Priya; Wardani, Arief Kusuma; Rawar, Ellsya Angeline
Jurnal Kimia Fullerene Vol 9 No 2 (2024): Fullerene Journal Of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v9i2.652

Abstract

Binahong ( Anredera cordifolia (Ten.) Steenis) merupakan tumbuhan yang memiliki banyak khasiat dan sering digunakan untuk mengobati berbagai macam penyakit. Salah satu kandungan senyawa yang terdapat dalam daun binahong adalah flavonoid yang berfungsi sebagai obat tradisional. Penelitian ini bertujuan untuk mengetahui pengaruh ekstraksi maserasi bertingkat terhadap kadar total flavonoid ekstrak binahong. Metode yang digunakan dalam penelitian ini adalah eksperimental. Daun binahong di ekstraksi secara maserasi bertingkat dengan menggunakan pelarut yang memiliki kepolaran berbeda. Pelarut yang digunakan terdiri atas pelarut n-heksana (nonpolar), etil asetat (semi polar), dan etanol 96% (polar). Analisis kualitatif pada penelitian ini menggunakan uji tabung dan analisis kuantitatif menggunakan metode spektrofotometri UV-Vis pada panjang gelombang maksimum 417,5 nm dengan pembanding standar rutin. Hasil analisis kualitatif ekstrak n-heksan, ekstrak etil asetat, dan ekstrak etanol 96% mengandung flavonoid positif. Berdasarkan pengujian kuantitatif diperoleh kadar flavonoid total ekstrak n-heksan, etil asetat, dan etanol 96% berturut-turut yakni sebesar 2,3102%; 3,6124%; dan 1,0264%. Hal ini menunjukkan bahwa penggunaan ekstraksi maserasi bertingkat memberikan pengaruh terhadap kadar total flavonoid yang dihasilkan pada masing-masing ekstrak.
Co-Authors Adi Hermawansyah Agusta, Herma Fanani Alda, Mahkota Amanda, Shalma Risqi Amarta, Fitri Dwi Amid, Azura Azizah, Bilqis Rahil Azizi, Khodadad Trimawan Azri, Anna Sa'dia Bayuaji, Dwibara Bunga, Cut Dewi Cahyaningrum, Putri Khaerani Dhani, Anidhita Putri Tamara Djoko Santosa Dwibara Bayuaji Ellsya Angeline Rawar Eltivitasari, Andita Erina, Chiquita Belva Fadlillah, Synta Haqqul Firdausa, Clara Adinda Hadi, Ismanurrahman Hamzah, Hasyrul Hidayat, Irfan Ahmad Kholifah, Eva Krisridwany, Annisa Kusumorini, Nindya Nadia, Mayla Eka Nisa Fitriyani, Nisa Nurjanah, Cut Intan Ayu Nurkhayati, Nurkhayati Permatasari, Desy Ayu Irma Permatasari, Lina Pradani, Missya Putri Kurnia Pratama, Digky Yoga Puspita Septie Dianita, Puspita Septie Putri, Nindya Yunia Ramadhani, Diva Laila Rianawati, Luluc Rochmiyanti, Hidayah Sabtanti Harimurti, Sabtanti Saputra, Ilham Fahmi Sari, Mely Anita Suhartomo, Dalri Muhammad Syarifuddin, Alfian Vaira, Tischa Vesandy, Ananda Salma Wardani, Arief Kusuma Wicaksari, Sifa Aulia Yudhawan, Indra