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Hartrianti, Pietradewi
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Colon Targeted Delivery Dosage Forms for Probiotics: A Review Anjasmara, Gede Anom; Hartrianti, Pietradewi; Iswandana, Raditya
Pharmaceutical Sciences and Research Vol. 10, No. 3
Publisher : UI Scholars Hub

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Encapsulation was a promising method for protecting probiotics from extreme conditions during their passage through the gastrointestinal tract and delivering probiotics to specific sites in the colon for colonization. Various dosage forms have been used in recent years to encapsulate probiotics to maintain cell viability during processing, storage, and through the digestive tract to provide health benefits. However, research related to the encapsulation of probiotics as the dosage forms for colon-targeted delivery systems was still quite limited to conventional dosage forms due to the sensitivity of probiotics to extreme conditions during the process. This review focuses on various types of dosage forms that are used in colon-targeted delivery systems for commonly used probiotic bacteria. In this review, we discussed the limitations of the current dosage forms used in probiotic encapsulation, along with the latest advancements in colon-targeted delivery systems for probiotic products. This review also covers future perspectives on the potential dosage forms that can effectively maintain probiotic viability and provide specific release in the colon.
Solid Lipid Nanoparticles (SLN): Formulation and Fabrication Punu, Gabriella F.; Harahap, Yahdiana; Anjani, Qonita Kurnia; Hartrianti, Pietradewi; Donnelly, Ryan F.; Ramadon, Delly
Pharmaceutical Sciences and Research Vol. 10, No. 2
Publisher : UI Scholars Hub

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Solid lipid nanoparticles (SLN) have emerged as a novel drug delivery system and have been utilized for delivering various kinds of drugs since the 1990s. These particles may consist of multiple solid lipids, including glycerides, waxes, and fatty acids, and can be stabilized by a wide range of surfactants. SLN have garnered significant attention from researchers due to its innovative and versatile nature. Moreover, such delivery system has numerous advantages over traditional colloidal carriers, such as liposomes, polymeric nanoparticles, and emulsions. Several research groups have been developing SLN formulations and fabrication techniques based on their intended purpose, and this research number is still increasing globally. Given the vast potential for the development of SLN in the future, coupled with the wide variety of materials and techniques to be considered during the manufacturing process, this paper provides an extensive overview of the general introduction of SLN, their benefits and drawbacks, and the numerous excipients which can be associated with the SLN formulation. Various aspects related to the models of drug incorporation and fabrication methods are also systematically discussed in this review. In addition, an analysis of the factors that impact the stability of the SLN will also be documented to provide further insight for future advancements in SLN research.
Co-Authors Anjani, Qonita Kurnia Anjasmara, Gede Anom Donnelly, Ryan F. Punu, Gabriella F. Raditya Iswandana RAMADON, DELLY Yahdiana Harahap