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All Journal Indonesian Journal of Life Sciences Pharmaceutical Sciences and Research (PSR)
Hartrianti, Pietradewi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Medicine & Pharmacology

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Colon Targeted Delivery Dosage Forms for Probiotics: A Review Anjasmara, Gede Anom; Hartrianti, Pietradewi; Iswandana, Raditya
Pharmaceutical Sciences and Research Vol. 10, No. 3
Publisher : UI Scholars Hub

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Abstract

Encapsulation was a promising method for protecting probiotics from extreme conditions during their passage through the gastrointestinal tract and delivering probiotics to specific sites in the colon for colonization. Various dosage forms have been used in recent years to encapsulate probiotics to maintain cell viability during processing, storage, and through the digestive tract to provide health benefits. However, research related to the encapsulation of probiotics as the dosage forms for colon-targeted delivery systems was still quite limited to conventional dosage forms due to the sensitivity of probiotics to extreme conditions during the process. This review focuses on various types of dosage forms that are used in colon-targeted delivery systems for commonly used probiotic bacteria. In this review, we discussed the limitations of the current dosage forms used in probiotic encapsulation, along with the latest advancements in colon-targeted delivery systems for probiotic products. This review also covers future perspectives on the potential dosage forms that can effectively maintain probiotic viability and provide specific release in the colon.
Downstream Critical Process Parameters for COVID-19 mRNA LNP Vaccine Production Aliyansah, Pradip Iramdhan; Kalyubi, Adelia Talita Oriana Athoulloh; Widiyanto, Azura Luna; E, Ervin; Loavenia, Michelle; Putri, Stevanie; Yuan, Tissa; Hartrianti, Pietradewi
Indonesian Journal of Life Sciences 2024: IJLS Vol 06 No.01
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v6i01.205

Abstract

The COVID-19 pandemic, triggered by the SARS-CoV-2 virus, has led to global efforts to mitigate its effects, with mRNA vaccines playing a crucial role. These vaccines use the virus's genetic sequence to prompt an immune response without introducing the live pathogen, showcasing substantial efficacy in protective immunity. The production of mRNA vaccines involves complex stages, including critical downstream processes of purification and formulation, vital for ensuring the vaccine's purity, potency, and safety. The structural components of mRNA vaccines, such as the Open Reading Frame (ORF), untranslated regions (UTRs), cap structure, and poly(A) tail, along with the delivery system using lipid nanoparticles (LNPs), are essential for their functionality and efficacy. Optimization of these elements is crucial for enhancing vaccine performance. Conventional, self-amplifying, and trans-amplifying mRNA vaccines represent the different strategies employed to target COVID-19 effectively. Each type utilizes structural and delivery innovations to stimulate a robust immune response. The review underscores the significance of precise control in the manufacturing process, highlighting its role in global health security and the advancement of vaccine technology. By understanding and optimizing critical process parameters (CPPs) in the downstream manufacturing process, the pharmaceutical industry can achieve the highest standards in vaccine production, significantly contributing to the fight against the pandemic and future vaccine development, ensuring a swift, effective response to global health crises. This review paper focuses on the downstream stages of mRNA vaccine production, comparing studies on CPP to emphasize the importance of stringent control measures for vaccine quality, safety, and efficiency.
Solid Lipid Nanoparticles (SLN): Formulation and Fabrication Punu, Gabriella F.; Harahap, Yahdiana; Anjani, Qonita Kurnia; Hartrianti, Pietradewi; Donnelly, Ryan F.; Ramadon, Delly
Pharmaceutical Sciences and Research Vol. 10, No. 2
Publisher : UI Scholars Hub

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Solid lipid nanoparticles (SLN) have emerged as a novel drug delivery system and have been utilized for delivering various kinds of drugs since the 1990s. These particles may consist of multiple solid lipids, including glycerides, waxes, and fatty acids, and can be stabilized by a wide range of surfactants. SLN have garnered significant attention from researchers due to its innovative and versatile nature. Moreover, such delivery system has numerous advantages over traditional colloidal carriers, such as liposomes, polymeric nanoparticles, and emulsions. Several research groups have been developing SLN formulations and fabrication techniques based on their intended purpose, and this research number is still increasing globally. Given the vast potential for the development of SLN in the future, coupled with the wide variety of materials and techniques to be considered during the manufacturing process, this paper provides an extensive overview of the general introduction of SLN, their benefits and drawbacks, and the numerous excipients which can be associated with the SLN formulation. Various aspects related to the models of drug incorporation and fabrication methods are also systematically discussed in this review. In addition, an analysis of the factors that impact the stability of the SLN will also be documented to provide further insight for future advancements in SLN research.
Co-Authors Aliyansah, Pradip Iramdhan Anjani, Qonita Kurnia Anjasmara, Gede Anom Donnelly, Ryan F. E, Ervin Kalyubi, Adelia Talita Oriana Athoulloh Loavenia, Michelle Punu, Gabriella F. Putri, Stevanie Raditya Iswandana RAMADON, DELLY Widiyanto, Azura Luna Yahdiana Harahap Yuan, Tissa