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All Journal International Journal of Clinical Inventions and Medical Sciences (IJCIMS) Jurnal Pengabdian Masyarakat Panacea Jurnal Riset Ilmiah
Rendati, Hema Novita
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Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Superoxide Dismutase from Marine as a Cytotoxic Agent Apriani, Dwi Wulan; Indrayati, Ana; Herdwiani, Wiwin; Rendati, Hema Novita; Zulfah, Khairina
International Journal of Clinical Inventions and Medical Sciences (IJCIMS) Vol 6 No 2: September 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.ijcims-0602.680

Abstract

The prevalence of cancer in Indonesia has shown an increase from 1.4 per 1000 population in 2013 to 1.79 per 1000 population in 2018. 70% of our planet is covered by unparalleled air and marine biodiversity. Therefore, medical researchers have focused on the marine world which has great potential, in the last six decades (Sagar et al. 2010). To find out other uses of biota, it is necessary to study the SOD of marine biota that reacts with their metal cofactors, to determine the specific SOD of some biota, to determine the SOD cytotoxic activity of several marine biota, to determine the mechanism of SOD of marine biota as anticancer. This literature review was carried out in several stages: formulating problems, collecting, evaluating, analyzing, and synthesizing data. The data sources used are international journals from publishers such as Science Direct, Elseiver, and SpringerLink between 2010 and 2021. The literature results obtained for the SOD classification of marine biota based on metal cofactors are 1,092 articles. The articles obtained will be selected and 52 articles that meet the inclusion criteria will be reviewed. The results of the search for specific SOD activities from marine biota were obtained by 1,243 articles. 13 articles that meet the inclusion criteria and will be reviewed. The results of the search for SOD cytotoxic activity from marine biota obtained 2,199 articles. 7 articles that met the inclusion criteria will be reviewed. The search results for specific SOD activities from marine biota were 2,496 articles. 8 articles that meet the inclusion criteria and will be reviewed. The results showed that SOD from marine biota had cytotoxic activity.
Peningkatan Pengetahuan Melalui Pemberian Informasi DAGUSIBU Sediaan Farmasi di Posyandu Pemurus Dalam Istiqomah, Nurul; Sari, Okta Muthia; Putra, Dian Kusuma; Sari, Novia Fahrina Purnama; Rendati, Hema Novita; Mahdi, Lukman
Jurnal Pengabdian Masyarakat Panacea Vol 3, No 4 (2025): Jurnal Pengabdian Masyarakat Panacea
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jpmp.v3i4.16745

Abstract

Masyarakat cenderung tidak mengetahui tata cara pengelolaan obat dengan tepat, yang berpotensi mengakibatkan dampak buruk pada kesehatan individu dan masyarakat secara keseluruhan. Kegiatan ini bertujuan untuk memberikan informasi terkait DAGUSIBU (Dapatkan, Gunakan, Simpan, dan Buang) sediaan farmasi di Posyandu Pemurus Dalam. Metode dalam kegiatan ini adalah ceramah edukasi kesehatan dengan media leaflet, yang disampaikan kepada masyarakat saat kegiatan posyandu. Kegiatan dilakukan melalui beberapa tahap yaitu perencanaan, persiapan, dan pelaksanaan. Evaluasi dilakukan melalui pretest dan posttest untuk mengukur efektivitas penyuluhan dalam meningkatkan pemahaman masyarakat terkait pengelolaan obat. Kegiatan diikuti 12 peserta yang merupakan masyarakat di wilayah kerja Posyandu Pemurus Dalam. Hasil kegiatan menunjukkan peningkatan pengetahuan peserta tentang pengelolaan sediaan farmasi yang tepat, dengan peningkatan pengetahuan rerata pretest ke postest sebesar 11,67%. Kesimpulan kegiatan ini pemberian informasi mengenai DAGUSIBU membantu dalam meningkatkan pengetahuan dan pemahaman masyarakat tentang pengelolaan obat yang tepat. Kata Kunci: Edukasi Kesehatan, Farmasi, Lingkungan, Obat The community often lacks awareness of proper procedures for obtaining, using, storing, and disposing of medicines, which can have adverse effects on individual and community health. This community service activity aims to provide information related to the DAGUSIBU (Obtain, Use, Store, and Dispose) of pharmaceutical preparations at the Pemurus Dalam Posyandu. The method used in this activity is counselling through leaflets distributed to the community during posyandu activities. The activity was carried out in several stages, namely planning, preparation, and implementation. Evaluation was conducted through pretests and posttests to measure the effectiveness of the counseling in improving the community's understanding of drug management. The activity was attended by 12 community members from the Pemurus Dalam Posyandu working area. The results of the activity showed an increase in community knowledge about the proper management of pharmaceutical preparations, with an average increase in scores from the pretest to the posttest of 11,67%. This activity concludes that providing information about DAGUSIBU increases community knowledge and understanding of proper medicine management.
UJI AKTIVITAS ANTIOKSIDAN FRAKSI AIR DAUN KRATOM (MITRAGYNA SPECIOSA) Rendati, Hema Novita
SINERGI : Jurnal Riset Ilmiah Vol. 3 No. 1 (2026): SINERGI : Jurnal Riset Ilmiah, January 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v3i1.2287

Abstract

Kratom leaves (Mitragyna speciosa) are traditionally used as a natural remedy and are known to contain various secondary metabolites with antioxidant potential. This study aimed to activate the antioxidant activity of the aqueous fraction of kratom leaves in vitro. Kratom leaves were extracted using methanol, then liquid-liquid fractionation was performed to obtain the air fraction. Phytochemical screening was performed qualitatively, while antioxidant activity was evaluated using the DPPH, ABTS, and FRAP methods. The phytochemical screening results showed that the air fraction contained alkaloids, phenolic compounds, tannins, quinones, saponins, and steroids/terpenoids, but no flavonoids were detected. Antioxidant activity tests showed that the air fraction exhibited strong antioxidant activity in the DPPH and ABTS methods, with IC₅₀ values of 66.69 ppm and 79.99 ppm, respectively, while the FRAP method showed moderate activity with an IC₅₀ value of 210.88 ppm. The difference in activity between the methods indicates that the air fraction is more effective as a free radical scavenger than as a reducing agent. Based on these results, the air fraction of kratom leaves has potential as a natural antioxidant source. However, further research is needed to identify specific active compounds and to assess biological activity in vivo.
Co-Authors Ana Indrayati Apriani, Dwi Wulan Mahdi, Lukman Nurul Istiqomah Putra, Dian Kusuma Sari, Novia Fahrina Purnama Sari, Okta Muthia Wiwin Herdwiani Zulfah, Khairina