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All Journal Cendekia Journal of Pharmacy Jurnal Insan Farmasi Indonesia INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) JIFI (Jurnal Ilmiah Farmasi Imelda) Indonesian Journal of Life Sciences Bencoolen Journal of Pharmacy Indonesian Journal of Medical and Pharmaceutical Science Medical Sains : Jurnal Ilmiah Kefarmasian
Sholeh, Aries Badrus
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health

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OPTIMASI DAN FORMULASI SABUN MANDI CAIR UNTUK BAYI DARI MINYAK BUAH ALPUKAT (PERSEA AMERICANA MILL) Yuyun Darma Ayu Ningrum; Widyaningrum, Naniek; Sholeh, Aries Badrus; Aprilianti, Yunita
Jurnal Insan Farmasi Indonesia Vol 7 No 1 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v7i1.1964

Abstract

Halal guarantees are implemented to provide comfort, security and peace of mind for people when using halal products. The active ingredient used in this research is avocado oil (Persea Americana Mill). The formula in this research was determined using the Simple Lattice Design (SLD) method with a True Experimental Laboratory research design. In this research, several tests were carried out on the physical properties of the preparation, namely organoleptic test, pH test, foam stability test, viscosity test and homogeneity test. Based on the recommended simple lattice design (SLD) method, data from 10 evaluation tests of formulation preparations were tested and an optimal formulation was obtained. This formula contains a concentration of 12.5% coconut oil and 17.5% KOH. Overall, the physical evaluation of liquid soap formulations in this study shows that R1, R2, and R3 meet the requirements for baby liquid soap according to established standards. The liquid soap for babies obtained from this research has a characteristic liquid consistency, is yellowish white in color and has a distinctive odor. The achieved pH value, foam stability, viscosity and homogeneity are in accordance with established standards.
OPTIMASI FORMULA DAN UJI EVALUASI FISIK SEDIAAN ESSENCE KOMBUCHA DENGAN VARIASI KONSENTRASI PROPYLENGLIKOL DAN GLISERIN Ayu Ningrum, Yuyun Darma; Sholeh, Aries Badrus; Ramadhini, Amelianingrum
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 7 No. 2 (2024): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v7i2.1518

Abstract

Skin problems can be treated with several cosmetic products such as essence. Essence is a skin care product that is part of skincare. Essence is a cosmetic product that has added value and optimal effects, namely as a humectant, ultraviolet protector, whitening agent, antioxidant, anti-inflammatory and skin rejuvenator. This Research using experimental method and aims to determine the optimal concentration of propylene glycol and glycerin in the optimum preparation of kombucha essence. In the results of the SLD method, 28 solutions were obtained, then for formula optimization the composition ratio between Propylene glycol and Glycerin was chosen as 11.5: 8.25 with a desirability value of 1.00. The resulting predicted values ??are a pH test of 5.255 and a viscosity test of 546.7. The analysis used a parametric sample t-test which showed that the results were not significantly different. This is shown by the value (p>0.05), so the results above indicate that the kombucha essence formula before and after the stability test was carried out obtained stable pH and viscosity values ??during storage based on the parametric sample t-test. The research results showed that the essence preparation made had an optimal formula in formula 3, namely transparent white, had a pH within the range so it was safe for the skin, was homogeneous and a viscosity value of 528.7 cp.
OPTIMIZATION OF VCO LOTION PREPARATIONS WITH VARIATIONS CETYL ALCOHOL AND CARRAGEEN CONCENTRATIONS USING SLD METHOD Sabiti, Farroh Bintang; Sholeh, Aries Badrus; Musyayadah, Zahrotul
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1303

Abstract

Lotion is a cosmetic preparation of an emollient group that contains a large amount of water. This formulation possesses several properties, namely, as a source of moisture for the skin, providing an oily layer that makes the hands and body soft. VCO is utilized as a natural skin moisturizer to prevent tissue damage and protect the skin. VCO has a very high moisture content, which prevents skin dryness. A lotion was formulated with an emulsifying agent to stabilize the emulsion system. One of the constituent ingredients of the lotion is cetyl alcohol, which functions as an emulsifying agent. Cetyl alcohol can be substituted by carrageenan, which serves the same function with the added benefit of being a humectant. The aim of this study was to identify the formulation of VCO lotion and to investigate the effect of different concentrations of the emulsifying agents cetyl alcohol and carrageen on physical evaluation tests, namely organoleptic tests, homogeneity tests, spreading tests, pH tests, adhesion tests, emulsion type tests, and viscosity tests in lotion formulations. An experimental method was employed in this study. The research was carried out by making lotions from various ingredients containing the active ingredient VCO at a concentration of 7%, as well as varying concentrations of cetyl alcohol (range 2-5%) and carrageenan (range 1-3%) as an emulsifying agent and additional ingredients for the preparations whose optimization had been determined using the simplex lattice design method ...
Formulasi dan Evaluasi Fisik Sediaan Sunscreen Powder Zink Oksida Latifah, Fadzil; Sholeh, Aries Badrus; Dharmawan, Jelshe Reada
Indonesian Journal of Medical and Pharmaceutical Science Vol. 4 No. 1 (2025)
Publisher : Sultan Agung Islamic University of Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v4i1.253

Abstract

Background: Zinc Oxide (ZnO) is a white sunscreen ingredient used to protect the skin layer from exposure to ultraviolet rays so that it can be used as an active ingredient in sunscreen. Powdered sunscreen preparations are fine and light powders that can provide a thin layer on the skin so that they are effective when used for faces with makeup. The purpose of this study was to formulate and provide physical preparations of zinc oxide powdered sunscreen with varying concentrations to see the best physical characteristics. Methods: This research is experimental in nature using 3 variations of zinc oxide concentrations of 5% (F1), 10% (F2), and 15% (F3) by evaluating the physical preparation including organoleptic tests, homogeneity tests, pH tests, fineness tests and stability tests. Results: The results of this study were obtained in the three formulas having the physical characteristics of a typical rosae odor, yellowish white in color, smooth texture, homogeneous dispersed powder, and stable in storage. In the pH test of sunscreen powder preparations, the concentration variations F1, F2, and F3 each obtained pH values of 5.24: 6.67, 7.31 respectively so that F3 meets the requirements for skin pH values in the range of 4 - 5.5. Conclusion: This study can conclude that the sunscreen powder that has the best characteristics is formula 1 with a zinc oxide concentration of 5%.
Optimization and Physical Stability of Toothpaste Preparations Essential Oils of Thyme (Thymus Vulgaris L.) and Peppermint (Mentha piperita L.) With SLD (Simple Latix Design) Latifah, Fadzil; Sholeh, Aries Badrus; Rofiah, Khafidhotur
BENCOOLEN JOURNAL OF PHARMACY Vol. 5 No. 1 (2025): April
Publisher : UNIB PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/bjp.v5i1.41137

Abstract

Thymus vulgaris L. essential oil contains the active compound thymol which has the potential as an antimicrobial, and peppermint essential oil contains menthol which has the potential to reduce the growth of Streptococcus mutans microorganisms. Based on the properties of these two ingredients, it is formulated in the form of toothpaste preparations. Methods method used quantitative research with laboratory experimental research Design using SLD (Simple Latix Design) with varying concentrations of Na CMC and SLS. SLD results results of 8 formulas obtained the optimum formula at a concentration of 1% NaCMC and 2% SLS and a result of 1,000. desirabiliti 1.000. Predictions based on SLD obtained a viscosity test of 21364.2 cPs, pH 9.00303, spreadability 4.3021 cm, and spreadability 4.3021 cm. Spreadability 4.3021 cm, foam height 12.6535 mm and One sample t test results (p>0.05) showed the results were not significantly different. showed the results were not significantly different. The results of the stability test for 3 cycles were tested organoleptical test has a white color, a distinctive smell of mint, a semi-solid texture and does not change for 3 cycles. changes for 3 cycles, ph test, spreadability test, foam height test and voiscosity test show results in accordance with the requirements based on the One Way ANOVA test results show (p>0.05) which means the results are not significantly different for 3 cycles. means the results are not significantly different for 3 cycles. In conclusion, all formulasin this study meet the required criteria for toothpaste preparations and the most optimum paste consistency is the Na variation. The most optimum paste consistency is the variation of Na CMC 1% and SLS 2%.
Analisis Tingkat Pengetahuan Pasien tentang Penggunaan Obat Kortikosteroid di Apotek Banyubiru Sehat Sholeh, Aries Badrus; Fatmasari, Heni; Tri Handayani, Setya
Indonesian Journal of Medical and Pharmaceutical Science Vol. 4 No. 2 (2025)
Publisher : Sultan Agung Islamic University of Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v4i2.405

Abstract

Background: Corticosteroids are widely used medications with potent anti-inflammatory and immunosuppressive effects. However, improper use without sufficient patient understanding can result in serious adverse effects, such as hypertension, osteoporosis, hyperglycemia, and Cushing’s syndrome. Preliminary observations at Banyubiru Sehat Pharmacy revealed high levels of corticosteroid purchases without prescriptions or proper patient knowledge. This highlights the importance of assessing patients’ understanding to ensure rational use. Methods: This descriptive observational study was conducted at Banyubiru Sehat Pharmacy in May 2025. Data were collected from 75 patients who had previously used corticosteroids, selected through purposive sampling. A validated and reliable questionnaire was used to evaluate their knowledge. Responses were analyzed using descriptive statistics and categorized into three levels: good (>75%), moderate (60–75%), and poor (<60%). Results: The majority of patients (66.67%) demonstrated a poor level of knowledge regarding corticosteroid use. Only 13.33% showed good understanding, while 20% had moderate knowledge. The average correct response rate was 46.4%. Most patients lacked awareness of the long-term risks and proper indications of corticosteroid therapy. Conclusion: Patients' knowledge of corticosteroid use at Banyubiru Sehat Pharmacy was predominantly low. Educational interventions, including counseling and informative materials, are needed to enhance patient awareness and promote safe, rational drug use.
Formulasi dan Evaluasi Fisik Sediaan Lipgloss Menggunakan Ekstrak Kering Buah Delima (Punica granatum) Januarti, Ika Buana; Inta, Icing Gustriani; Sholeh, Aries Badrus
INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Vol 9, No 1 (2025)
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/inpharnmed.v9i1.5930

Abstract

Ekstrak kering buah delima berpotensi sebagai bahan aktif dalam kosmetik, khususnya lipgloss yang berfungsi mempercantik sekaligus merawat bibir. Formulasi lipgloss dengan ekstrak delima ini diharapkan memberikan manfaat ganda, yaitu estetika dan perawatan kulit bibir yang lebih sehat.  Penelitian ini bertujuan untuk merumuskan dan mengevaluasi stabilitas fisik sediaan lipgloss menggunakan ekstrak kering buah delima (Punica granatum) dengan konsentrasi 5% (F1), 10%, (F2) dan 15% (F3). Evaluasi stabilitas fisik dilakukan selama 4 minggu terhadap parameter organoleptis, homogenitas, pH, dan viskositas. Hasil menunjukkan bahwa sediaan lipgloss dengan ekstrak delima memberikan warna merah muda yang bervariasi sesuai konsentrasi. F1, F2 dan F3 memiliki sifat fisik (organoleptik, homogen, pH dan  viskositas) yang memenuhi syarat. Penambahan ekstrak delima tidak menurunkan mutu fisik sediaan selama penyimpanan 4 minggu pada suhu kamar. Ekstrak delima dapat digunakan sebagai pewarna alami dalam sediaan lipgloss dan memiliki stabilitas fisik yang baik
Comparative Dissolution Profiles of Branded versus Generic Clopidogrel Bisulfate: Assessing In Vitro Bioequivalence Raisinghani, Prettish Kishore; Kristyawan, Fitri; Sholeh, Aries Badrus; Aliyansah, Pradip Iramdhan
Indonesian Journal of Life Sciences 2025: IJLS Vol 07 No.02
Publisher : Indonesia International Institute for Life Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54250/ijls.v7i02.233

Abstract

Clopidogrel, an antiplatelet agent widely prescribed for thromboembolic disorders, holds a substantial market presence in Indonesia, with a valuation of IDR 4.52 trillion. While plavix (branded form) remains as one of the leading treatments for such conditions, its high cost makes it unaffordable for a significant portion of Indonesia’s population. This underscores the necessity for generic alternatives that mimic the properties of the branded product to ensure broader accessibility and affordability for patients. To achieve this, generic clopidogrel bisulfate tablets must undergo the same crucial biopharmaceutical stages such as disintegration, drug release, aqueous dissolution, and systemic absorption to achieve therapeutic efficacy similar to the branded version. Despite being the most expensive tablet, the branded form serves as a standard reference to evaluate the dissolution profile, quality, and efficacy of locally manufactured generic formulations. This study investigates the dissolution profile and physical properties of generic clopidogrel bisulfate tablets produced by PT Phapros TBK, compared to a branded clopidogrel bisulfate product licensed by Sanofi in France. Quality attributes including weight and size uniformity, hardness, and disintegration time were assessed as per the Indonesian Pharmacopoeia (5th edition) standards. Dissolution tests were conducted at pH levels of 1.2, 4.5, and 6.8, with 12 sample replications at each interval, to determine bioequivalence between the two formulations. Through this research, the aim is to illuminate the bioequivalence of generic and branded clopidogrel products in Indonesia, offering insights into their interchangeability and potential clinical impact in a high-demand market.
EVALUASI IMPLEMENTASI PERSYARATAN HALAL PRODUKSI PRODUK TABLET VITAMIN C DI PT. X Sabiti, Farroh Bintang; Wijaya, Gabriell Angela Monique; Sholeh, Aries Badrus; Rakhmaningsih, Haninta
Cendekia Journal of Pharmacy Vol 8, No 2 (2024): Cendekia Journal of Pharmacy
Publisher : Institut Teknologi Kesehatan Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v8i2.256

Abstract

Indonesia is a country with a Muslim-majority population reaching up to 87.18%. therefore, the government guarantees that citizens consume halal products as stated in UU No. 33 Th. 2014 about the guarantee of halal products as a halal regulation of food products, including pharmaceutical preparation. As a pharmaceutical industry, PT. X evaluates the criteria of halal products. This research evaluated the implementation of the halal production requirement of Vitamin C tablet at PT. X. This observational, practical research and interview method evaluated the data by analyzing and checking the halal requirement components. Evaluation is carried out by analysis using the checklist method. The researchers adjusted the 12 indicators of halal production of Vitamin C tablet at PT. X. Data collection was carried out by filling out a checklist from The Indonesian Council of Ulama (MUI) regarding halal criteria at the production stage of pharmaceutical products at PT. X. Based on the research results, it is known that the production process doesn't fulfill all the indicators for halal production implementation for Vitamin C tablet at PT. X with a percentage of 75%. However, PT. X has made efforts to ensure that the products produced are not contaminated with haram/unclean materials. Therefore, it can be concluded that the vitamin C products from PT. X are guaranteed to be halal.Keywords: Pharmaceutical Industry, Production, Halal
Co-Authors Aliyansah, Pradip Iramdhan Aprilianti, Yunita Ayu Ningrum, Yuyun Darma Dharmawan, Jelshe Reada Fadzil Latifah, Fadzil Fatmasari, Heni Inta, Icing Gustriani Januarti, Ika Buana Kristyawan, Fitri Musyayadah, Zahrotul Naniek Widyaningrum Raisinghani, Prettish Kishore Rakhmaningsih, Haninta Ramadhini, Amelianingrum Rofiah, Khafidhotur Sabiti, Farroh Bintang Tri Handayani, Setya Wijaya, Gabriell Angela Monique Yuyun Darma Ayu Ningrum